NEUROPSYCHOBIOLOGY神经心理生物学
NEUROPSYCHOBIOLOGY(英文缩写 NEUROPSYCHOBIOLOGY),ISSN 0302-282X,eISSN 1423-0224,中文译名:神经心理生物学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 12.329 | Q1 |
| 2022 | 3.200 | Q2 |
| 2023 | 2.300 | Q2 |
| 2024 | 3.100 | Q1 |
| 2025 | 3.700 | Q1 |
NEUROPSYCHOBIOLOGY 最新收录文献
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1. Childhood Trauma Clusters, Klotho, Matrix Metalloproteinase-9, and Cognitive Function in Adolescents with Major Affective Disorders.
PMID:日期:2026-09-21Childhood trauma is common among adolescents with major affective disorders (MADs), including bipolar disorder and major depressive disorder. The relationships between childhood trauma subtypes, cognitive function, and the anti-aging protein Klotho and matrix metalloproteinase-9 (MMP-9) in adolescents with MADs remain unknown. We enrolled 95 adolescents with MADs (48 bipolar disorder, 47 major depressive disorder) and 45 healthy controls. Childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form. A k-means cluster analysis identified trauma-based subgroups among patients. Serum Klotho and MMP-9 levels and cognitive functions (working memory, Wisconsin Card Sorting Test, and Go/No-Go task) were assessed. Group differences were examined using generalized linear models adjusting for demographic variables, clinical symptoms, and medication use. Three trauma clusters were identified: low trauma (n = 40), emotional neglect (EN)-focused (n = 47), and multi-trauma (n = 8) groups. The EN-focused group exhibited significantly lower Klotho levels than healthy controls and higher MMP-9 levels than all other groups. Cognitively, the EN-focused group showed reduced working memory accuracy and more trials to complete the first category on the Wisconsin Card Sorting Test, whereas the multi-trauma group demonstrated increased working memory errors and reduced Go/No-Go accuracy. Adolescents with EN-focused trauma displayed a distinct biological-cognitive profile characterized by lower serum Klotho, higher MMP-9, and executive dysfunction. These findings suggest that deprivation-related adversity may be associated with convergent Klotho-MMP-9 alterations and neurobiological vulnerability in MADs. Longitudinal studies are warranted to clarify causal mechanisms.
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2. Group-Dependent Associations Between Plasma Adiponectin and Hippocampal Subregional Volumes in Schizophrenia.
PMID:日期:2026-09-18Leptin and adiponectin are adipose-derived hormones that cross the blood-brain barrier and modulate hippocampal plasticity, neurogenesis, and inflammatory signaling. Dysregulated adipokine signaling may provide a biological link between systemic metabolic disturbances and hippocampal vulnerability in schizophrenia. This study investigated whether peripheral adipokines are associated with hippocampal subregional volumes in schizophrenia. Thirty-five patients with schizophrenia (SCZ) and 29 healthy controls (HCs) were enrolled in this cross-sectional study. Plasma leptin and adiponectin were quantified using ELISA. Longitudinal hippocampal subregions were delineated manually, and transverse subfields were segmented using FreeSurfer. Group differences in adipokines were assessed with Welch's t-tests. Hippocampal volumetric differences were examined using MANCOVAs followed by univariate ANCOVAs, adjusting for age, sex, body mass index (BMI), and estimated total intracranial volume (eTIV). Group-dependent adipokine-volume associations were evaluated using group × adipokine interaction models followed by group-stratified regression analyses. Plasma leptin was significantly higher in SCZ than in HCs, whereas adiponectin showed a non-significant reduction. Patients with schizophrenia exhibited widespread hippocampal atrophy across both longitudinal and transverse subregions. Within the schizophrenia group, higher plasma adiponectin was associated with smaller hippocampal head volume, whereas no corresponding association was observed in healthy controls. Adiponectin-hippocampal associations appeared group-dependent within this sample. Higher plasma adiponectin was associated with smaller hippocampal head volume in schizophrenia but not in healthy controls, supporting further investigation of metabolic-neural relationships in larger longitudinal and mechanistic studies.
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3. Circulating glutamate and incident metabolic syndrome during antidepressant treatment in major depressive disorder.
PMID:日期:2026-09-09Metabolic Syndrome (MetS) is increasingly prevalent worldwide, raising the risk of diabetes and cardiovascular diseases. Glutamate, a key excitatory neurotransmitter involved in depression and antidepressant response, is also implicated in metabolic dysregulation ; whereas glutamine/glutamate ratio, reflecting the balance between neurotransmission and metabolism, may provide additional insight into this relationship. This study prospectively examines the associations of blood glutamate levels and the glutamine/glutamate ratio with MetS in depressed patients treated with antidepressants for six months. In the METADAP cohort, 164 non-overweight patients with major depressive disorder were evaluated for blood glutamate and glutamine levels at baseline, three months (M3), and six months (M6) after initiating antidepressant treatment. Logistic and linear regression models were used to explore associations between glutamate levels, the glutamine/glutamate ratio, MetS incidence, its individual components, and insulin resistance. The cut-off threshold was internally validated using 1,000 bootstrap resamples with optimism correction. Glutamate levels decreased significantly over time. Higher odds of MetS were observed with elevated glutamate at M3 [OR = 1.032, 95% CI 1.01-1.06, p = 0.001] and with smaller reduction from baseline [OR = 1.03, 95% CI 1.028-1.034, p < 0.001]. Glutamate levels above 38 µmol/L at M3 tripled the risk of developing MetS [OR = 3.24, 95% CI 1.83-5.72, p < 0.001]. Similar trends were observed for the glutamine/glutamate ratio, supporting its value as a complementary metabolic marker. Similar trends were observed for the glutamine/glutamate ratio, supporting its value as a complementary metabolic marker. Monitoring circulating glutamate levels and the glutamine/glutamate ratio at month 3 may help identify patients at higher metabolic risk during antidepressant treatment and support increased clinical vigilance with respect to metabolic outcomes.
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4. Analysis of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and -2 and Fractalkine in Depression and Childhood Adversity: An Exploratory Study.
PMID:日期:2026-09-01Adverse childhood experiences (ACEs) and major depressive disorder (MDD) are associated with altered inflammatory processes, dysregulation of the hypothalamic-pituitary-adrenal axis and an increased risk of developing metabolic diseases. Soluble Triggering Receptor Expressed on Myeloid Cells-1 and -2 (sTREM1, sTREM2) and Fractalkine (CX3CL1) are markers of the innate immune system regulating inflammatory response but are relatively underexplored in ACE and MDD. In this exploratory study, we measured serum sTREM1, sTREM2, CX3CL1, and pro-inflammatory cytokines in 23 women with ACE and MDD, 23 women with MDD without ACE, 22 healthy women with ACE with no current or lifetime MDD and 25 healthy women with neither ACE nor MDD. Additionally, explorative correlations between levels of sTREM1, sTREM2, CX3CL1, and cytokines, measures of trauma, depressive symptoms, anxiety, self-reported stress, metabolic parameters, and cortisol release were calculated. The four groups in this study did not differ in levels of sTREM1 and sTREM2. Healthy women without ACE had higher CX3CL1 concentrations than both depression groups. They also had lower IL-8 and IL-18 levels than each of the other three groups (ACE+/MDD+, ACE-/MDD+, and ACE+/MDD-). sTREM1 and CX3CL1 were related to pro-inflammatory activity, such as TNF-α and NGF, while sTREM2 was associated with an increased metabolic risk. Furthermore, CX3CL1 correlated with lower stress ratings and a higher cortisol release to psychosocial stress induction, while sTREM2 correlated positively with symptoms of depression and anxiety. Lower CX3CL1 and increased cytokines might be an unspecific correlate of mental disorders and early traumatic experiences. sTREM1, sTREM2, and CX3CL1 seem to be associated with somatic as well as mental health variables. Further studies are needed to investigate the specific role of sTREM1, sTREM2, and CX3CL1 in the interplay between physical and mental health.
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5. Gene Therapy for Autism Spectrum Disorder: Preclinical Advances, Translational Barriers, and Ethical Dimensions - A Scoping Review.
PMID:日期:2026-08-07Autism spectrum disorder (ASD) lacks disease-modifying therapies. Gene therapy offers a promising avenue to target the underlying molecular causes of ASD, particularly in monogenic or syndromic forms where single-gene mutations play a central role. A scoping review was conducted following the PRISMA-ScR framework. We searched PubMed, Scopus, Web of Science, PsycINFO, and the Cochrane Library (2000-July 2025), with the last search completed in July 2025. Eligible studies included preclinical or translational investigations involving gene-therapy modalities (e.g., AAV vectors, ASOs, CRISPR-based editing) targeting high-confidence ASD-linked genes; non-gene-therapy studies, unrelated conditions, reviews, and non-English papers were excluded. Data were charted using a standardized extraction form and synthesized descriptively across two evidence streams. Stream 1 evaluated preclinical studies of gene therapy, while Stream 2 examined translational advances and ethical considerations. Twenty-one preclinical studies were identified in Stream 1, focusing on genes such as UBE3A, MECP2, FMR1, SHANK3/2, SCN2A, and SYNGAP1. Most demonstrated molecular correction and improvements in synaptic, electrophysiological, and behavioral outcomes, with therapeutic effects observed from early developmental to adult timepoints. Stream 2 synthesized 12 studies highlighting translational challenges, including delivery innovations (e.g., engineered viral capsids, nanoparticles), safety concerns (immune responses, dose-dependent toxicities), and ethical considerations (pediatric consent, neurodiversity perspectives, equity in access). Limitations include heterogeneity across models, reliance on rodent studies, and absence of completed human clinical trials. Gene therapy for ASD shows considerable promise but faces significant translational and ethical hurdles. Standardized study designs, comprehensive safety evaluation, and transparent stakeholder engagement will be critical for developing responsible and effective clinical applications.
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6. Grey matter structural asymmetry and premenstrual dysphoric disorder.
PMID:日期:2026-08-06Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behaviour, and vulnerability to mental disorders. Despite evidence for lateralized sensitivity to hormonal fluctuations, the cortical and subcortical asymmetry profile of individuals with premenstrual dysphoric disorder (PMDD), a hormone-related mood disorder associated with alterations in brain structure, remains unexplored. In this study, a total of 68 females with PMDD and 51 healthy females underwent magnetic resonance imaging (MRI) during the luteal phase of the menstrual cycle. Structural asymmetry was assessed using voxel-wise whole-brain analysis and region of interest (ROI) approaches for grey matter volume (GMV), as well as ROI-based analysis of cortical thickness. Associations between asymmetry and symptom severity were also investigated. Whole-brain analyses revealed significantly greater leftward GMV asymmetry in PMDD participants in two clusters within the anterior fusiform gyrus and the anterior insula. ROI-based analyses did not show any asymmetry group differences in either GMV or cortical thickness. Within the PMDD group, greater leftward asymmetry in the amygdala GMV was moderately associated with higher irritability. These findings provide novel, region-specific evidence for structural asymmetry in PMDD and suggest that lateralized brain architecture may contribute to affective symptom expression in this disorder.
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7. Implications of Cortisol in Cognitive Impairment Observed in Cancer Patients: A Systematic Review.
PMID:日期:2026-08-03Cancer-related cognitive impairment (CRCI) is a frequent adverse effect observed in patients, but the underlying mechanisms are still unclear. Cortisol has been proposed as a potential contributor to CRCI, so the aim of this review was to systematically evaluate the evidence on the role of cortisol in CRCI. This review followed PRISMA guidelines and was registered in PROSPERO (CRD42024570561). The search was conducted in PubMed, Web of Science, SCOPUS, ProQuest, OSF PREPRINTS, OATD, NDLTD Global E-Theses and Dissertations, and EBSCO. Inclusion criteria were studies on adult cancer patients/survivors assessing cortisol and CRCI, published in English from inception to January 30, 2025. The risk of bias was analyzed with the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, and a qualitative GRADE-like summary of the certainty of the evidence. Twelve articles were finally included and analyzed using content analysis methods. Overall, findings suggest that altered diurnal cortisol rhythm (i.e., blunted cortisol secretion pattern) might be involved in CRCI; although results are inconsistent and the exact mechanisms remain unknown. Stress response associated to diagnosis, surgery, and life changes, as well as certain treatments, of cancer patients may contribute to dysregulated cortisol secretion, which in turn has been linked to CRCI. Additionally, personality traits and sociodemographic factors may act as mediators between cortisol release and CRCI. Recent data suggest cortisol relates to CRCI; however, future research should standardize cognitive outcomes and cortisol assessment methods, and consider clinical, sociodemographic, and psychological factors that may modulate stress responses.
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8. Anhedonia and Reward Learning in Major Depression: State or Trait?
PMID:日期:2026-07-22Anhedonia and reward processing deficits are core features of major depressive disorder (MDD). However, their persistence following remission remains unclear, hindering the differentiation between state versus trait characteristics. This study investigated clinically assessed anhedonia and reward-related learning in individuals with current MDD (MD), remitted MDD (RMD), and healthy controls (HCs). We assessed 26 individuals with current MDD, 35 with RMD, and 37 HC. Anhedonia was measured using the Clinician-Administered Snaith-Hamilton Pleasure Scale (SHAPS-C-TR). Reward-related learning was evaluated using the probabilistic reward task (PRT). Depressive and anxiety symptoms were also assessed. The MD group exhibited significantly higher anhedonia and greater depressive and anxiety symptoms compared to both RMD and HC groups. Crucially, anhedonia scores did not differ between the RMD and HC groups. While a significant learning effect on the PRT was observed across the entire sample, there were no significant differences in task performance among the three groups, even after controlling for covariates. Clinically assessed anhedonia appears to be a state-dependent symptom that normalizes with remission. In contrast, reward-related learning, assessed via the PRT, was not significantly impaired in either current or remitted depression. These findings suggest a potential dissociation between the experience of clinically assessed anhedonia and reward learning deficits in MDD.
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9. Monoamine Neurotransmitters in Saliva: Novel Biomarkers of CNS Function and Therapeutic Response?
PMID:日期:2026-07-21Monoamine neurotransmitters, including catecholamines (i.e., norepinephrine, epinephrine, and dopamine), and the indolamine serotonin play important roles in signaling in the central and peripheral nervous systems. Alterations in neurotransmission may be suggestive of neuroendocrine or psychiatric disorders, may reflect therapeutic responses, and are often considered relevant to mental health. Monoamine modulators and their metabolites are detectable in saliva, suggesting that saliva could represent an attractive, noninvasive, and cost-effective matrix for identifying and monitoring conditions in both healthy and diseased individuals. Accordingly, measuring salivary monoamine neurotransmitters may have scientific and possible clinical relevance. In this review, we summarize and critically evaluate current evidence on salivary dopamine, norepinephrine, epinephrine, serotonin, and their respective metabolites. Although further research is required to clarify their biological significance and clinical applicability, existing findings suggest that salivary monoamine measurement may hold potential, albeit with important limitations.
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10. Autonomic Nervous System Regulation in Women: Electrophysiological Signatures of Stress Reactivity across the Female Lifespan.
PMID:日期:2026-07-13Women exhibit distinct stress-response patterns shaped by dynamic interactions between ovarian hormones, the autonomic nervous system (ANS), and cortical stress-processing circuits. Across the female lifespan, hormonal transitions, including the menstrual cycle, pregnancy, postpartum period, perimenopause, and menopause, are associated with heightened vulnerability to mood and anxiety disorders, underscoring the need for sex-specific physiological frameworks. This narrative review synthesizes current evidence on how hormonal fluctuations modulate stress physiology in women, with a particular focus on noninvasive biomarkers derived from heart rate variability (HRV), electrodermal activity (EDA), and electroencephalography (EEG). HRV emerges as a key marker of female stress reactivity, reflecting shifts in sympathetic-parasympathetic balance that vary across hormonal states and life stages. Estrogen is generally associated with enhanced vagal modulation and higher HRV, whereas progesterone and estrogen withdrawal are linked to reduced vagal modulation and relatively greater sympathetic activation, patterns that are especially pronounced during the luteal phase, pregnancy progression, postpartum, and menopause. Complementary measures provide additional insight: EDA indexes sympathetic arousal and captures hormonally driven changes in emotional reactivity, while EEG reflects cortical dynamics underlying affective style, cognitive control, and stress sensitivity. Current evidence suggests that multimodal HRV-EDA-EEG assessment may provide a more comprehensive physiological characterization of stress-related autonomic and cortical regulation by integrating complementary signals across central and peripheral systems. However, its clinical and predictive utility remains to be established in longitudinal, hormone-informed studies. By consolidating findings across key female life stages, this review highlights how hormonal modulation of ANS-brain interactions contributes to sex-specific stress profiles and psychiatric risk. We conclude that multimodal physiological assessment represents a promising research framework for characterizing women's stress physiology, while its translation into personalized prevention or intervention strategies requires further validation through standardized, longitudinal, and hormone-informed studies.