Mycotoxin Research真菌毒素研究
Mycotoxin Research(英文缩写 MYCOTOXIN RES),ISSN 0178-7888,eISSN 1867-1632,中文译名:真菌毒素研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.082 | Q2 |
| 2022 | 3.000 | Q2 |
| 2023 | 2.600 | Q2 |
| 2024 | 3.100 | Q2 |
| 2025 | 3.500 | Q2 |
Mycotoxin Research 最新收录文献
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1. An integrated adaptive framework for mycotoxin management in African cereals: evidence from a scoping review.
PMID:日期:2026-09-24Mycotoxins threaten food safety, public health, and trade in Africa, where cereals are staple foods largely produced and consumed through informal systems. This scoping review synthesizes evidence on pre- and post-harvest mycotoxin management in African cereal systems and translates it into an integrated adaptive framework for policy and practice. A structured literature search conducted in Google Scholar, Web of Science, and Scopus identified 9,817 records, of which 33 primary studies met the eligibility criteria. The included studies covered interventions across the cereal value chain, including biocontrol, chemical pest management, drying, storage, and processing practices. Biocontrol interventions, particularly atoxigenic Aspergillus flavus products such as Aflasafe reduced aflatoxin levels by 60-100% across the reviewed studies, with long-term field evidence showing that more than 95% of treated grains remained below 20 µg/kg in Nigeria and 75% below 4 µg/kg in Senegal. Bt maize also reduced fumonisin contamination by approximately 74% in South Africa. Post-harvest interventions, including improved drying, hermetic storage, sorting, and HACCP-based processing, achieved variable but substantial reductions, with hand sorting reducing aflatoxin B1 and fumonisin B1 to less than 6% and 5% of initial levels, respectively, and HACCP-based processing reducing aflatoxins to below 5 µg/kg. However, persistent constraints, including climate variability, limited infrastructure, low awareness, gender inequities, informal market dominance, and fragmented regulatory frameworks, continue to limit large-scale effectiveness. These findings informed an Integrated Adaptive Mycotoxin Management Framework grounded in a One Health perspective to support sustainable mycotoxin risk reduction in African cereals.
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2. Mycotoxin contamination in food and feed: Occurrence, co-occurrence, combined impacts on human and animal health, climate change implications, risk assessment, and mitigation strategies.
2. 食品和饲料中的霉菌毒素污染：发生情况、共现现象、对人畜健康的综合影响、气候变化影响、风险评估及缓解策略PMID:日期:2026-09-15Mycotoxins are toxic secondary metabolites produced by numerous fungi that infect crops during pre- and post-harvest stages. Aflatoxins, ochratoxins, fumonisins, zearalenone, and trichothecenes are of greatest concern due to their widespread occurrence and high toxicity. Consumption of mycotoxin-contaminated food and feed poses serious public health risks, as these compounds are linked to carcinogenic, neurotoxic, nephrotoxic, hepatotoxic, and immunotoxic effects. The frequent co-occurrence of multiple mycotoxins further amplifies health risks through additive or synergistic interactions and contributes to substantial economic losses. This review provides an updated overview of the global distribution and co-occurrence of major mycotoxins in agricultural products, their individual and combined toxicological effects on human and animal health, and the regulatory standards and maximum permitted levels for mycotoxins in food and feed. In addition, this review discusses the impact of climate change on mycotoxin contamination in food and feed, exposure, and associated health risks. It further outlines mycotoxin risk assessment procedures and highlights mitigation strategies for reducing contamination and limiting human and animal exposure risks. Ultimately, this review underscores the urgent need for integrated mycotoxin risk management strategies and strengthened global surveillance systems to safeguard food safety, protect human and animal health, and enhance food security.
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3. Diversity and toxigenic potential of Aspergillus section Flavi strains associated with maize and its main by-products in northern Côte d'Ivoire.
PMID:日期:2026-09-12Maize is a staple food in many parts of sub-Saharan Africa, and is very often prone to contamination by mycotoxins, particularly aflatoxins, which are known for their harmful effects on human and animal health. This study aimed to investigate the diversity and toxigenic potential of Aspergillus section Flavi strains associated with maize and its main by-products in the Korhogo region of northern Côte d'Ivoire. A total of 50 samples were collected, including 10 maize ears, 22 stored grains, 8 cracked maize and 10 maize flours. The analysis was carried out using a polyphasic approach comprising morphological and molecular characterisation, and aflatoxin production. A total of 151 isolates were recovered including genera Aspergillus, Fusarium, Penicillium and Rhizopus. Six Aspergillus species were identified: A. flavus (64 strains), A. niger (17 strains), A. tamarii (6 strains), A. luchuensis (6 strains), A. fumigatus (4 strains), and A. aflatoxiformans (1 strain). Aspergillus flavus was the most represented in the section Flavi, accounting for 90.1% of the strains, followed by A. tamarii (8.5%) and A. aflatoxiformans (1.4%). Among the A. flavus strains, 67.2% were aflatoxigenic, producing aflatoxins B, whereas 32.8% were non-aflatoxigenic. The A. aflatoxiformans strain produced aflatoxin B (AFB) and aflatoxin G (AFG). The A. tamarii isolates were non-aflatoxigenic. These findings provide valuable insights into the ecology and toxigenic profiles of Aspergillus section Flavi in maize-based systems and contribute to the scientific basis for developing targeted strategies to improve food safety in the region.
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4. Smaller laboratory sample masses yield lower measured aflatoxin concentrations in heterogeneous maize and groundnut lots.
PMID:日期:2026-09-11Aflatoxin contamination in cereals and oilseeds is highly heterogeneous, making representative laboratory sampling a major challenge. Although laboratory sample mass is recognised as an important determinant of sampling uncertainty, its relationship with the aflatoxin concentration obtained from heterogeneous lots has received limited direct investigation. This study evaluated the association between laboratory sample mass and measured aflatoxin concentration in groundnut and maize lots. Groundnut slurry samples were assessed at laboratory sample masses of 3 and 7 kg, while maize samples were assessed at 1, 5, and 10 kg. Aflatoxins were quantified using VICAM AflaTest immunoaffinity clean-up and fluorometric detection. Across the studied lots, larger laboratory sample masses generally yielded higher measured aflatoxin concentrations than smaller masses, with statistically significant differences in most comparisons. These findings indicate that laboratory sample mass can influence the aflatoxin concentration obtained from heterogeneous lots and should therefore be clearly specified in experimental design, method reporting, and interpretation.
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5. Evaluation of commercial maize hybrids for Aspergillus ear rot resistance and aflatoxin accumulation under natural and artificial inoculation conditions.
PMID:日期:2026-09-09Aspergillus ear rot (AER) and aflatoxin contamination in maize threaten global food security and public health, with developing countries such as Bangladesh-where maize cultivation is rapidly expanding-being particularly vulnerable. This study evaluated the resistance of 25 commercially available maize hybrids to AER infection and aflatoxin accumulation under natural infection (field exposure without artificial inoculation) and artificial inoculation conditions. Hybrids were artificially inoculated using a toxigenic Aspergillus flavus strain (ES103) via the pin bar inoculation method to ensure uniform infection. Disease severity, kernel infection rates, and aflatoxin levels were assessed using standardized protocols. Significant variation was observed among hybrids, with disease severity ratings ranging from 5 to 7 on a 7-point scale, and no hybrid showed complete resistance. The hybrid 'Mohabeer' exhibited the lowest kernel infection rate (42.59%), the second-lowest total aflatoxin levels (536.31 ng/g total, 115.63 ng/g AFB), and the lowest disease severity (5). In comparison, 'Uttoron Super' showed the highest infection rate (87.04%), accompanied by high disease severity (7) and aflatoxin accumulation (2,397.43 ng/g total). Artificial inoculation increased aflatoxin levels by over 90% compared to natural infection conditions. Husk tightness is generally considered a physical barrier to natural infection, a strong positive correlation (r = 0.82) was identified between husk tightness index (HTI) and aflatoxin accumulation, suggesting that looser husks (higher HTI) are associated with greater aflatoxin accumulation after infection. In contrast, no correlation existed between aflatoxin levels and yield performance. These findings demonstrate widespread susceptibility among commercial maize hybrids to AER and aflatoxin contamination, emphasizing the critical need for integrated pre- and post-harvest management strategies and informed hybrid selection in high-risk areas.
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6. Multi-year monitoring of deoxynivalenol (DON) in wheat from Türkiye: occurrence and temporal trends.
PMID:日期:2026-09-07Deoxynivalenol (DON) is one of the most frequently occurring mycotoxins in wheat and poses significant concerns for food safety. In this study, a total of 540 wheat samples collected between 2014 and 2024 were analyzed to evaluate the occurrence and temporal variability of DON contamination. DON was detected in 139 samples (25.74%), indicating a moderate level of contamination. The results revealed considerable inter-annual variability, with the annual prevalence of DON-positive wheat samples ranging from 16.1% to 35.0%. Despite the frequent occurrence of DON, only two samples (0.37%) exceeded the maximum level established by Commission Regulation (EU) 2023/915, as amended by Commission Regulation (EU) 2024/1022. The analytical method demonstrated good performance in terms of linearity, sensitivity, accuracy, and precision, and long-term quality control results confirmed the stability and reliability of the method throughout the monitoring period. Overall, the findings indicate that while DON contamination is relatively common in wheat, the associated food safety risk in terms of regulatory limits remains low. The observed variability highlights the importance of continuous long-term monitoring for improved risk assessment and food safety management.
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7. Efficacy evaluation of a fermented milk containing inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharomyces cerevisiae to ameliorate the toxic effects of dietary aflatoxins and fumonisins in pigs: a pilot study.
PMID:日期:2026-09-04Inactivated microorganisms may reduce mycotoxins' bioavailability, although in vivo evidence is limited especially in farm animals. This pilot study evaluated whether a fermented milk (FM) containing heat-inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharomyces cerevisiae at 1% (w/w) mitigated the toxic effects of dietary aflatoxins (AFs) and fumonisins (FBs) in weaned piglets. Twenty-four male crossbred piglets were assigned to a 2 × 2 × 2 factorial design (n = 3 per group) with AFs (0; 1.11-1.28 mg/kg, sum of AFB, AFB, AFG and AFG), FBs (0.78-0.99; 9.22-9.53 mg/kg, sum of FB and FB), and FM (0; 39 g/animal/day, equivalent to 5% of basal diet) for 28 days. AFs reduced (P < 0.05) the body weight gain and feed consumption. AFs or AFs + FBs exposure were associated with hepatic lesions, whereas FBs caused increased pulmonary and renal lesions (P < 0.05). FM was associated with lower (P < 0.05) scores of FBs' lung lesions and AFs + FBs' kidney lesions, but did not consistently improve growth performance or hepatic and renal biochemical parameters. Plasma AFP and urinary FB were lower (P < 0.05) in AFs- or FBs-exposed animals receiving FM, while plasma and urinary AFM or FB were not reduced by the FM. In conclusion, FM containing inactivated L. rhamnosus and S. cerevisiae had partial protective effects against organ-specific mycotoxin injury, with limited evidence of AFs bioavailability reduction, considering n = 3 per experimental group. Further studies should evaluate different inclusion levels of microorganisms and mycotoxins, as well as other potentially adsorptive microorganisms, with a focus on microorganism-mycotoxin interactions within the gastrointestinal tract.
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8. Occurrence of ergot alkaloids and deoxynivalenol in Brazilian wheat and cattle feed determined by UHPLC-MS/MS.
PMID:日期:2026-08-28This study presents a novel and comprehensive assessment of the presence of ergot alkaloids (EAs, ergocristine, ergocornine, α-ergocryptine, ergotaminine, and ergosine) and deoxynivalenol (DON), individually and in combination, in wheat and cattle feed in Brazil. A total of 92 wheat grain and 79 cattle feed samples from different feed and food Brazilian industries were analyzed by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) between January 2023 and March 2025. Approximately 78% of wheat samples and 72% of cattle feed samples contained at least one EA. Ergosine was the predominant alkaloid in wheat, with a mean concentration of 8.06 µg/kg. In contrast, ergotaminine was the primary contaminant in cattle feed, with a mean concentration of 2.37 µg/kg. DON also showed high contamination levels, with mean concentrations of 1,913 µg/kg in wheat and 222.14 µg/kg in cattle feed. All five EAs were simultaneously detected in 8/92 wheat samples, whereas no simultaneous occurrence of all five EAs was observed in cattle feed samples. The co-occurrence of DON and different EAs ranged from 14.1 to 65.2% in wheat and from 6.3 to 40.5% in cattle feed. These findings highlight the importance of mycotoxin monitoring in Brazil and demonstrate the robustness of UHPLC-MS/MS as a tool for detecting these mycotoxins in complex matrices such as animal feed.
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9. Alcoholic beer fermentation: impact of glutathione and peroxidase fortification on deoxynivalenol reduction.
PMID:日期:2026-08-24The use of contaminated cereals in fermentation processes can elicit a marked response from yeasts in the presence of mycotoxins, as indicated by the production of defense compounds such as peroxidase (PO) and glutathione (GSH) to reduce mycotoxin damage. The objective of this study was to investigate the effect of fortifying GSH and PO levels in alcoholic fermentation as a strategy for reduce concentration deoxynivalenol (DON) during the brewing process. The QuEChERS method was validated for quantifying the mycotoxin and estimating reduction. Fermentation was conducted in a reactor containing 20 mL of synthetic wort inoculated with Saccharomyces cerevisiae (0.115 g). The reduction of DON was evaluated using a 2 fractional factorial design with the following independent variables: GSH concentration (0-50 mg L), PO activity (0-0.4 U mL), fortification time (0-48 h), and DON concentration (0.1-0.3 µg mL). The results of reducing the concentration of DON in experimental planning ranged from 76,2% to non-detection of mycotoxin, significantly, with PO activity as a significant variable. Fortification with GSH and PO was significant in the decrease of DON when it was at a higher level, increasing by 39% compared to the control. Supplementation with GSH and PO demonstrated in this study indicates the effectiveness of DON reduction in the evaluated contamination levels.
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10. Coexistence and combined toxic effects of principal emerging and common mycotoxins.
PMID:日期:2026-08-20Mycotoxins are toxic secondary metabolites produced by fungi and pose a major threat to global food and feed safety. Although common mycotoxins, represented by aflatoxins (AFT), zearalenone (ZEN), ochratoxin A (OTA), and deoxynivalenol (DON), are subject to strict regulation, contamination with emerging mycotoxins, such as beauvericin (BEA), enniatins (ENNs), and moniliformin (MON), has been increasingly reported. These emerging mycotoxins often coexist with common mycotoxins in food and feed, resulting in complex mixed contamination. Such coexistence may give rise to complex combined toxic effects, including synergistic, additive, and antagonistic interactions, and the underlying mechanisms remain unclear, posing challenges to accurate risk assessment. This review summarizes the coexistence patterns, detection frequencies, and contamination levels of major emerging and common mycotoxins in various food and feed matrices across different geographical regions, while also considering modified/masked mycotoxins. It further examines the individual toxic effects and mechanisms of emerging mycotoxins, including ionophoric activity, apoptosis induction, and metabolic disturbance. In addition, this review focuses on the complex toxicological interactions arising from combined exposure to emerging and common mycotoxins and the molecular pathways involved. Overall, the available evidence indicates that emerging mycotoxins should be incorporated into mixture-oriented monitoring and cumulative risk assessment frameworks for food and feed safety.