FEMS MICROBIOLOGY REVIEWSFEMS微生物学评论
FEMS MICROBIOLOGY REVIEWS(英文缩写 FEMS MICROBIOL REV),ISSN 0168-6445,eISSN 1574-6976,中文译名:FEMS微生物学评论 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 15.177 | Q1 |
| 2022 | 11.300 | Q1 |
| 2023 | 10.100 | Q1 |
| 2024 | 12.300 | Q1 |
| 2025 | 16.900 | Q1 |
FEMS MICROBIOLOGY REVIEWS 最新收录文献
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1. Tat-dependent protein translocation and its evolution.
PMID:日期:2026-09-22The Tat system is a general translocation machinery responsible for the transport of folded proteins across biological membranes that are energized by a proton or sodium motive force at these membranes. Protein substrates are characterized by usually amino-terminal signal peptides harboring a conserved twin-arginine sequence motif. Phylogenetic analyses suggest that a Tat system was already present in the last universal common ancestor (LUCA). Today, Tat systems are found in bacteria, archaea, and bacteria-derived organelles. Minimally, Tat systems are composed of one TatC-family component and one TatA/B-family component, with multiple copies of these components forming the functional translocon, while more complex Tat systems exist that require additional homologs of TatA/B or TatC. Due to its ability to translocate folded proteins with bound cofactors, the Tat system is essential for a wide range of important physiological pathways, such as many anaerobic respirations or photosynthesis. With a focus on evolutionary aspects, and by including recent structural and mechanistic insights, we herein review our current knowledge on this mechanistically unique translocation pathway.
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2. From holobionts to habitats: opportunities and limitations of microbiome-assisted restoration strategies of marine ecosystem engineers.
PMID:日期:2026-08-26Marine ecosystem engineers such as corals, seaweeds, and seagrasses are foundational to coastal ecosystems, yet are declining at unprecedented rates due to accelerating climate and anthropogenic pressures. Microbiome-based approaches have attracted attention as a promising avenue to enhance the resilience and recovery of these organisms. Over the past decade, diverse marine probiotic microbes have been isolated and shown to positively influence key host life functions, including growth, development, reproduction, responses to environmental stressors, and pathogen defence. However, current research remains confined to laboratory settings, with few practical field applications tested or utilised, likely driven by practical and technological challenges and lacking communication between science and policy. To help close this gap, we propose a set of risk and success assessment criteria for microbiome-assisted restoration. This framework is built around four pillars: (1) ensuring environmental compatibility of candidate probiotics, (2) establishing scientific validation for their mechanisms of action, (3) securing legal clarity before application, and (4) implementing mandatory in situ monitoring to evaluate ecological outcomes. By integrating these pillars into a cycle of risk assessment, monitoring, and adaptive management, microbiome-assisted restoration could progress from an experimental concept to a practical application complementing existing conservation tools, strengthening the resilience of these ecosystems.
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3. Interactions between extracellular vesicles and viruses: lessons learned across species and kingdoms.
3. 细胞外囊泡与病毒的相互作用：跨物种和跨界的经验启示PMID:日期:2026-06-23[中文摘要] 细胞外囊泡（EVs）是细胞释放的膜性纳米颗粒，有助于塑造细胞外环境、清除细胞废物并介导细胞间通讯。其释放遍及不同界、物种和细胞类型，凸显了其功能重要性。病毒的释放同样在进化上广泛存在且具有异质性，病毒已进化出劫持宿主细胞机制的能力，以促进其在所有生命分支中的复制和传播。几乎所有病毒，无论是否有包膜，都会利用细胞外囊泡来调节感染动态，而细胞外囊泡在宿主对感染的反应中也发挥着关键作用。本综述探讨了在病毒物种的系统发育多样性中细胞外囊泡与病毒之间的相互作用。我们敦促病毒学家和细胞外囊泡生物学家超越单一感染模型，从近缘及远缘相关病毒（无论其感染哺乳动物、脊椎动物、昆虫、植物、细菌还是其他宿主）中所观察到的独特概念和共有共性中汲取经验。为促进这些努力，我们提供了关于DNA和RNA病毒科当前知识的全面、按分类学组织的概述，并讨论了感染期间细胞外囊泡释放和功能中反复出现的模式。
[英文摘要] Extracellular vesicles (EVs) are membranous nanoparticles released by cells that help shape the extracellular environment, remove cellular waste, and mediate cell-to-cell communication. Their release is ubiquitous across kingdoms, species, and cell types, highlighting their functional importance. Nearly as evolutionarily widespread and heterogeneous is the release of viruses, which have evolved to co-opt the host's cellular machinery to facilitate their replication and spread within all branches of life. Nearly all viruses, enveloped or not, repurpose EVs to modulate infection dynamics, while EVs also play a crucial role in the host's response to infection. This review explores the interplay between EVs and viruses across the phylogenetic diversity of virus species. We urge virologists and EV biologists to look beyond a single infection model and learn from the unique concepts and shared commonalities observed between close, as well as distantly related viruses, whether they infect mammals, vertebrates, insects, plants, bacteria, or more. To facilitate these efforts, we provide a comprehensive, taxonomical overview of the current knowledge regarding DNA and RNA virus families, and discuss recurring motifs in EV release and function during infection.
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4. Plasma-activated water: a dual-action disinfectant and wound-healing therapy for diabetes-related foot infections.
PMID:日期:2026-01-02Globally, approximately 18.6 million individuals develop diabetes-related foot ulcers each year, with 50%-60% of these cases subsequently becoming infected. Diabetes-related foot infections (DFI) are a serious complication often resulting in gangrene, lower extremity amputation and death-outcomes exacerbated by multidrug-resistant and biofilm-forming pathogens that render standard antibiotics and antiseptics inadequate, driving up healthcare costs and morbidity. Addressing this challenge necessitates the development of novel, dual-action therapeutic strategies capable of eradicating infection while simultaneously promoting tissue regeneration. Plasma-activated water (PAW) is an emerging solution, produced by treating water with cold plasma; an ionized gas that generates a complex mixture of reactive oxygen and nitrogen species. PAW elicits potent broad-spectrum antimicrobial and antibiofilm activity against a wide range of pathogens implicated in chronic wound infections, including DFI. PAW has also been shown to accelerate wound healing by modulating immune cell activity and promoting epithelial cell proliferation and migration. In this review, we summarize DFI prevalence and recurrence, PAW generation and physicochemical properties, antimicrobial and antibiofilm efficacy against relevant pathogens, effects on cellular responses, therapeutic potential and current limitations. This review positions PAW as a dual-action, resistance-refractory therapeutic strategy for DFIs and other chronic wounds and outlines the translational pathway towards clinical implementation.
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5. Computational methods in physical virology: a critical perspective across lengths and timescales.
PMID:日期:2026-01-02Physical virology investigates viral particles by focusing on their assembly, stability, mechanics, and interactions with host cells, neutralizing antibodies, and surfaces. Within this field, computational virology is becoming an indispensable pillar, serving as a "computational microscope" that bridges the spatio-temporal scales of viral processes, from individual protein dynamics to capsid assembly and cellular entry. This perspective article offers a critical overview of the current state, challenges, and future directions of computational approaches in physical virology. Our vision is anchored in the research presented at the 2025 EMBO/FEBS Lecture Course on Physical Virology held in Sant Feliu de Guixols, Spain, and complemented by a targeted survey among attendees. We survey the principal methodological frameworks in use, from all-atom to multiscale molecular simulations, mesoscale simulations, and growing integration of artificial intelligence (AI) tools. We also critically examine the central obstacles impeding the field's progress, including the computational-experimental gap, limited accessibility to simulation data, reproducibility concerns, and systemic gender and geographic inequities. Finally, we outline future perspectives, proposing that integrating physics-aware AI with multiscale simulation frameworks, combined with community-driven data-sharing initiatives, will transform the computational microscope from a descriptive tool into a predictive engine for antiviral therapies, rational vaccine design, and biotechnological innovation.
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6. From colonization to immune evasion: a synthesis of the interaction strategies that drive Staphylococcus aureus infection.
PMID:日期:2026-01-02Staphylococcus aureus remains a major human and veterinary pathogen, driven by multiple virulence processes, including toxin activity, biofilm formation, metabolic adaptation, regulatory networks, antimicrobial resistance, and strain-specific traits. Many of these processes involve host-pathogen protein-protein interactions (PPIs). This review focuses on PPIs as a major mechanistic layer that links adhesion, invasion, and immune evasion across infection stages. We synthesize available evidence to explain how selected PPIs support the transition from carriage to invasive disease. We first compare surface adhesins that use distinct binding architectures, including Dock, Lock, and Latch, the Collagen Hug, and the tandem β-zipper, to achieve force-resilient attachment under physiological shear. We then organize immune-evasion PPIs along the chronology of host defence, from early sensing and antimicrobial barriers to phagocyte recruitment, complement and opsonization, intraphagosomal killing, and adaptive immunity. This staged view highlights how mechanoadaptive anchoring, redundancy, and multifunctionality can contribute to robust infection phenotypes and suggests therapeutic opportunities involving allosteric modulation, decoy-based restoration of host pathways, and multi-target biologics.
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7. From biogenesis to host modulation: the expanding biology of oral streptococcal membrane vesicles.
PMID:日期:2026-01-02Bacterial extracellular membrane vesicles (bEVs) provide fundamental biological functions through communication, ecological adaptation, and mediation of host interactions. Gram-positive oral streptococci were long considered to be incapable of bEVs production due to their thick peptidoglycan. In contrast, recent advances in imaging, biochemical isolation, and multi-omics profiling have revealed that bEVs production is common and may represent a general trait of streptococci. This review summarizes current research on the biogenesis, cargo composition, and functional roles of bEVs, with an emphasis on oral streptococcal vesicles and their contributions to oral microbial ecology and host responses. We highlight methodological innovations for isolation and characterization of bEVs that have led to the discovery of species-specific bEVs cargo. Functionally, bEVs participate in diverse biological activities, including horizontal gene transfer, antimicrobial peptide delivery, virulence and redox modulation, and they profoundly influence host immunity by modulating cytokine signaling, epithelial barrier function, and immune pathways. Emerging evidence further suggests active roles in polymicrobial biofilm development and systemic dissemination of microbial signals relevant to health and disease. By integrating biochemical, structural, ecological, and immunological perspectives, this review provides a comprehensive overview of the current state of streptococcal and Gram-positive bEVs research and discusses its translational potential to support oral and general health.
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8. Bacterial extracellular vesicles as players in biofilm dynamics and community interactions.
PMID:日期:2026-01-02The ability to use vesicles to deliver cargo safely across distance is a valuable strategy that appears to be universal across all life. The ability of prokaryotes to accomplish this is a relatively new idea, but one that is expanding rapidly. In this review, we will describe what bacterial extracellular vesicles (bEVs) are and where they come from. We will also summarize what has been learned about their biogenesis and function through foundational planktonic studies. Using this as a backdrop, we will then contextualize new and exciting discoveries made as the focus of the field has shifted to studying bEVs in more complex multi-species and biofilm communities. We will explore how, when and where bEVs are produced in biofilms and how the circumstances of their formation can affect communication, matrix remodeling, community metabolism, organization, and defense. The boundless versatility of bEVs makes them essential contributors to bacterial community life and also offers great potential for exploitation as applied biologics.
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9. Unveiling the role of extracellular vesicles in HIV infection: molecular mechanisms, viral persistence, and therapeutic opportunities.
PMID:日期:2026-01-02Human immunodeficiency virus (HIV) infection remains a major global health challenge despite the success of antiretroviral therapy, largely due to the persistence of viral reservoirs and chronic immune dysregulation. Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication during viral infection, operating at the interface between viral and host cellular pathways. Depending on their cellular origin and molecular cargo, EVs can exert context-dependent effects, with studies suggesting roles in both viral dissemination and persistence, as well as in the modulation of antiviral immune responses. This review examines the molecular mechanisms through which EVs have been proposed to contribute to HIV infection, focusing on host-virus interactions, immune regulation, chronic inflammation, and viral latency. We further discuss emerging therapeutic strategies targeting EV biology, including approaches aimed at modulating EV biogenesis and cargo composition, as well as the development of engineered EVs as platforms for drug delivery, gene editing, and immune modulation. Overall, this study highlights the emerging roles of EVs in HIV infection, emphasizing both their potential relevance and the limitations that currently complicate the interpretation of EV-associated effects.
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10. Functional, structural, and taxonomical diversity of glycoside transporters in bacteria.
PMID:日期:2026-01-02Glycoside metabolization is a crucial function in bacteria and a key feature in fermentation and synthetic biology. To feed on various glycosides with complex structures, bacteria have developed very diverse mechanisms to recognize, transport, and degrade them. Despite their crucial role, transporters are hard to identify and study due to challenges in expressing membrane proteins in recombinant form and the fact that most bacteria are uncultivable. In this review, we present the available methods and technologies for identifying and characterizing bacterial glycoside transporters. We consolidate existing knowledge on experimentally validated glycoside transporters from different families, including TonB-dependent transporters, ATP-binding cassette transporters, the phosphotransferase system, and the major facilitator superfamily, highlighting their taxonomic, functional, mechanistic, and structural diversity. The disparity between the number of functionally characterized glycoside transporters and the vast amount of sequence data available underlines the need for more efficient approaches to determine their specificity and to better understand the molecular mechanisms of glycoside utilization in bacteria.