OPTICS AND LASERS IN ENGINEERING光学与激光工程
OPTICS AND LASERS IN ENGINEERING(英文缩写 OPT LASER ENG),ISSN 0143-8166,eISSN 1873-0302,中文译名:光学与激光工程 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.666 | Q1 |
| 2022 | 4.600 | Q1 |
| 2023 | 3.500 | Q2 |
| 2024 | 3.700 | Q2 |
| 2025 | 4.200 | Q2 |
OPTICS AND LASERS IN ENGINEERING 最新收录文献
-
1. Polarization resolved deep ultraviolet microscopy for label free imaging with enhanced nuclei and fiber contrast.
PMID:日期:2025-10-01Deep ultraviolet (DUV) microscopy is a rapid, label-free imaging technique widely used in biological applications. However, fibrillar structures, which provide crucial insights into tissue organization, are often overlooked. In this work, we introduce a polarization-resolved DUV microscope capable of extracting both nuclear and fiber features. Illumination at 265 nm enhances nuclear contrast, while polarization imaging reveals fiber orientation. Four images are captured sequentially to calculate the linear polarization properties of the tissue medium. To address pixel misalignment between multiple images, we apply adaptive local thresholds to extract valid features for precise registration. The degree of linear polarization and angle of polarization exhibit significant changes as light passes through tissue samples, revealing variations in polarization states. This additional polarization contrast offers a new dimension of analysis, potentially enhancing the characterization of biological tissues.
-
2. Strain heterogeneity measurement of mouse sclera by stereo digital image correlation under inflation testing.
2. 在膨胀试验下通过立体数字图像相关测量小鼠巩膜的应变异质性PMID:日期:2025-02-27Scleral biomechanics has emerged as an important topic in eye research, particularly for understanding the pathophysiology of diseases such as myopia and glaucoma. For the biomechanical characterization of scleral tissue, the three-dimensional digital image correlation (3D-DIC) method has been widely used as an accurate optical tool for full-field deformation measurements during ex vivo inflation testing in different species like cow, pig, human, rat, and tree shrew, with a large range of eye size roughly between 38 mm and 7 mm. Mouse has been used as the common model in glaucoma and more recently in myopia research, but until now, due to the small eye size (~ 4 mm in diameter), no stereo-DIC has been proposed for whole-eye inflation testing. We present the first setup of inflation testing of intact mouse eyes for measuring the strain field of the sclera by the 3D-DIC method during quasi-static pressure loading, along with an analysis of the variables required to design a stereo-DIC system. In addition, we investigated the biomechanical characterization of mouse sclera, and the evolution of the sclera strain distribution during a loading-unloading cycle. We discovered that the scleral strain distribution during quasi-static linear changes of intraocular pressure (IOP) follows a Lognormal distribution whose standard deviation represents a metric of the biomechanical heterogeneity of the strain response.
-
3. Revealing physical interactions of ultrasound waves with the body through photoelasticity imaging.
3. 通过光弹性成像揭示超声波与身体的物理相互作用PMID:日期:2024-06-14Ultrasound is a ubiquitous technology in medicine for screening, diagnosis, and treatment of disease. The functionality and efficacy of different ultrasound modes relies strongly on our understanding of the physical interactions between ultrasound waves and biological tissue structures. This article reviews the use of photoelasticity imaging for investigating ultrasound fields and interactions. Physical interactions are described for different ultrasound technologies, including those using linear and nonlinear ultrasound waves, as well as shock waves. The use of optical modulation of light by ultrasound is presented for shadowgraphic and photoelastic techniques. Investigations into shock wave and burst wave lithotripsy using photoelastic methods are summarized, along with other endoscopic forms of lithotripsy. Photoelasticity in soft tissue surrogate materials is reviewed, and its deployment in investigating tissue-bubble interactions, generated ultrasound waves, and traumatic brain injury, are discussed. With the continued growth of medical ultrasound, photoelasticity imaging can play a role in elucidating the physical mechanisms leading to useful bioeffects of ultrasound for imaging and therapy.
-
4. {"_":"Polarization-sensitive optical coherence tomography for renal tumor detection in human kidneys.","i":["ex vivo"]}
4. {“_”：“偏振敏感光学相干断层扫描用于检测人类肾脏中的肾肿瘤。”，“i”：[“离体”]}PMID:日期:2023-10-23Kidney cancer is a kind of high mortality cancer because of the difficulty in early diagnosis and the high metastatic dissemination in treatments. The surgical resection of tumors is the most effective treatment for renal cancer patients. However, precise assessment of tumor margins is a challenge during surgical resection. The objective of this study is to demonstrate an optical imaging tool in precisely distinguishing kidney tumor borders and identifying tumor zones from normal tissues to assist surgeons in accurately resecting tumors from kidneys during the surgery. 30 samples from six human kidneys were imaged using polarization-sensitive optical coherence tomography (PS-OCT). Cross-sectional, , and spatial information of kidney samples were obtained for microenvironment reconstruction. Polarization parameters (phase retardation, optic axis direction, and degree of polarization uniformity (DOPU) and Stokes parameters (Q, U, and V) were utilized for multi-parameter analysis. To verify the detection accuracy of PS-OCT, H&E histology staining and dice-coefficient was utilized to quantify the performance of PS-OCT in identifying tumor borders and regions. In this study, tumor borders were clearly identified by PS-OCT imaging, which outperformed the conventional intensity-based OCT. With H&E histological staining as golden standard, PS-OCT precisely identified the tumor regions and tissue distributions at different locations and different depths based on polarization and Stokes parameters. Compared to the traditional attenuation coefficient quantification method, PS-OCT demonstrated enhanced contrast of tissue characteristics between normal and cancerous tissues due to the birefringence effects. Our results demonstrated that PS-OCT was promising to provide imaging guidance for the surgical resection of kidney tumors and had the potential to be used for other human kidney surgeries in clinics such as renal biopsy.
-
5. Design of illumination system using characterized illuminances for smartphone-based fundus camera.
5. 基于智能手机的眼底照相机的照明系统设计PMID:日期:2023-05-23Recently, smartphone-based fundus camera (SBFC) research has been actively conducted in response to the need to expand medical infrastructure in underdeveloped countries and the increased telemedicine since the COVID-19 pandemic. Compared to the conventional table-top system, SBFCs have technical challenges that make it difficult to guarantee uniform illumination and avoid back-reflection because of the design constraints of minimizing the form factor and cost. This paper proposes a novel illumination design methodology using characterized illuminance to obtain high-quality fundus images for SBFCs. Key performance indicators (KPIs), such as retinal uniformity, back-reflection suppression, and optical efficiency, were defined to evaluate the performance of the illumination system. Each KPI was calculated using optical simulation software based on Monte-Carlo ray tracing and mapped into a normalized three-dimensional coordinate, the retinal illumination performance space (RIPS). In RIPS, the KPIs are combined into a single parameter , which is the quantitative difference evaluated as the Euclidean distance between the ideal and actual design point. A compact SBFC illumination system with five design variables was presented to verify the proposed methodology. The final design values at the minimum were determined using the Taguchi method and response surface methodology. Finally, a working prototype was built, and fundus images were acquired by clinical testing under institutional review board approval. The fundus image had sufficient brightness and resolution to diagnose the lesion with a viewing angle of approximately 50° in one shot.
-
6. Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.
6. 瞬时偏振光显微镜pi（IPOLπ）用于定量成像眼部组织中的胶原蛋白结构和动力学PMID:日期:2023-03-28Collagen architecture determines the biomechanical environment in the eye, and thus characterizing collagen fiber organization and biomechanics is essential to fully understand eye physiology and pathology. We recently introduced instant polarized light microscopy (IPOL) that encodes optically information about fiber orientation and retardance through a color snapshot. Although IPOL allows imaging collagen at the full acquisition speed of the camera, with excellent spatial and angular resolutions, a limitation is that the orientation-encoding color is cyclic every 90 degrees (π/2 radians). In consequence, two orthogonal fibers have the same color and therefore the same orientation when quantified by color-angle mapping. In this study, we demonstrate IPOLπ, a new variation of IPOL, in which the orientation-encoding color is cyclic every 180 degrees (π radians). Herein we present the fundamentals of IPOLπ, including a framework based on a Mueller-matrix formalism to characterize how fiber orientation and retardance determine the color. The improved quantitative capability of IPOLπ enables further study of essential biomechanical properties of collagen in ocular tissues, such as fiber anisotropy and crimp. We present a series of experimental calibrations and quantitative procedures to visualize and quantify ocular collagen orientation and microstructure in the optic nerve head, a region in the back of the eye. There are four important strengths of IPOLπ compared to IPOL. First, IPOLπ can distinguish the orientations of orthogonal collagen fibers via colors, whereas IPOL cannot. Second, IPOLπ requires a lower exposure time than IPOL, thus allowing faster imaging speed. Third, IPOLπ allows visualizing non-birefringent tissues and backgrounds from tissue absorption, whereas both appear dark in IPOL images. Fourth, IPOLπ is cheaper and less sensitive to imperfectly collimated light than IPOL. Altogether, the high spatial, angular, and temporal resolutions of IPOLπ enable a deeper insight into ocular biomechanics and eye physiology and pathology.
-
7. Microscale Creep and Stress Relaxation Experiments with Individual Collagen Fibrils.
7. 单个胶原纤维的微尺度蠕变和应力松弛实验PMID:日期:2021-11-21Nanoscale macromolecular biological structures exhibit time-dependent behavior, yet a quantitative understanding of their time-dependent mechanical behavior remains elusive, largely due to experimental challenges in attaining sufficient spatial and temporal resolution and control of stress or strain in conditions that guarantee their molecular integrity. To address this gap, an experimental methodology was developed to conduct creep and stress relaxation experiments with individual mammalian collagen fibrils. An image-based edge detection method implemented with high magnification optical microscopy and combined with closed-loop proportional-integral-derivative (PID) control was implemented and calibrated to apply constant force or stretch ratio values to individual collagen fibrils via a Microelectromechanical Systems (MEMS) device. This experimental methodology allowed for real-time control of uniaxial tensile stress or strain with 27 nm displacement resolution. The overall experimental system was tuned to apply step inputs with rise times below 0.5 s, less than 2.5% overshoot, and steady-state error less than 0.5%. Three individual collagen fibrils with diameters 101-121 nm were subjected to creep and stress relaxation tests in the range 4-20% engineering strain, under partially hydrated conditions. The collagen fibrils demonstrated non-linear viscoelastic behavior that was described well by the adaptive quasi-linear viscoelastic model. The results of this study demonstrate for the first time that mammalian collagen fibrils, the building blocks of connective tissues, exhibit nonlinear viscoelastic behavior in their partially hydrated state.
-
8. Two-photon polymerization nanofabrication of ultracompact light scattering spectroscopic probe for detection of pre-cancer in pancreatic cyst.
8. 双光子聚合纳米制备用于检测胰腺囊肿癌前病变的超小型光散射光谱探针PMID:日期:2021-03-20Pancreatic cancer has one of the worst survival rates of all major cancers, with pancreatic cystic lesions accounting for one in three pancreatic surgeries. The current gold-standard for diagnosis of pancreatic cyst malignancy is based on the endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) procedure, which suffers from a low accuracy in detecting malignancy. Here we present the design and two-photon polymerization based fabrication of refractive and reflective non-contact probes, capable of rapid surveillance of the entire internal cyst surface-an advance over the contact probe we recently developed that allowed, for the first time, reliable evaluation of pancreatic cyst malignant potential . We employed a novel two-photon polymerization technique, which allows direct laser-writing to an accuracy of tens of nanometers, to fit the probe within the 540 micrometer internal diameter EUS-FNA needle. The newly constructed probes show excellent separation of the illumination and collection beams, essential for proper operation of the spatial gating method. These probes can be used clinically to perform rapid "optical biopsy", ultimately eliminating unnecessary pancreatic surgeries on benign cysts and dangerous delays in surgical removal of malignant cysts, improving patient prognosis and quality of life.
-
9. Design, Development, and Performance Comparison of Wide Field Lensless and Lens-Based Optical Systems for Point-of-Care Biological Applications.
PMID:日期:2020-08-16Lensless biological imaging systems are an emerging alternative to conventional microscopic systems because they enable a wide field of view imaging. While most microscopic systems sacrifice the field of view for magnification, lensless systems have taken advantage of small imaging pixel size, projection, digital magnification, and post-processing to compensate for diffracted images. A new lens-based system is designed to have the exact same wide field of view as that of a basic lensless setup. A new compound lens system design is utilized to achieve an explicit aim to have the same fields of view as the lensless setup. Then the characteristics of these two optical imaging setups (lensless and lens-based setups) are compared at this level of complexity to see what the minimal systems principles are needed to achieve the biological imaging goals for simplified and less expensive future designs. For both imaging systems, images of biological entities are recorded with the help of the same CMOS imaging device and computer software. The main contribution of this work is an exhaustive comparison between the performance characteristics of both systems using optical standards and biological images.
-
10. Compact snapshot dual-mode interferometric system for on-machine measurement.
10. 用于机上测量的紧凑型快照双模干涉系统PMID:日期:2020-05-08To meet the need of on-machine metrology in optical manufacturing, a compact and snapshot dual-mode interferometric system is proposed for surface shape and roughness measurement. To simplify the measurement process between surface shape and roughness, a novel concept of using optical filters to separate the beam paths in the reference arm is introduced. A pixelated camera with a micro-polarizer array acquires four pi/2 phase-shifted interferograms simultaneously to minimize the environmental disturbance. Besides, the configuration-optimization-based subaperture stitching technique is introduced to extend the measurable aperture range. Both numerical analysis and experiments have been carried out to demonstrate the feasibility of the proposed compact snapshot dual-mode interferometer. The proposed system provides a powerful and portable tool to achieve on-machine surface characterization of various optical elements over a wide range of spatial frequencies and aperture sizes.