JOURNAL OF ENDODONTICS牙髓病学杂志
JOURNAL OF ENDODONTICS(英文缩写 J ENDODONT),ISSN 0099-2399,eISSN 1878-3554,中文译名:牙髓病学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.422 | Q1 |
| 2022 | 4.200 | Q1 |
| 2023 | 3.500 | Q1 |
| 2024 | 3.600 | Q1 |
| 2025 | 3.900 | Q1 |
JOURNAL OF ENDODONTICS 最新收录文献
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1. Autotransplantation versus Immediate Implant Placement for Replacement of Non-Restorable Posterior Teeth: A Systematic Review and Meta-Analysis.
1. 自体牙移植与即刻种植修复无法保留的后牙：系统评价与荟萃分析PMID:日期:2026-09-29The aim of the present systematic review and meta-analysis was to compare the clinical success rates of immediate dental implants (IMM) and autotransplanted mature teeth (AUT), and to identify patient-related and intraoperative factors that influence short- to mid-term outcomes. The study protocol was prospectively registered on PROSPERO (CRD420251077420). A systematic electronic search adhering to the 2020 PRISMA guidelines was conducted across PubMed, ScienceDirect, and the Cochrane Library for studies published up to April 2026. Cohort studies reporting clinical success and/or survival rates for IMM and AUT with a minimum follow-up of 12 months were eligible. Methodological quality was assessed using the Newcastle-Ottawa scale. Publication bias was evaluated using Egger's regression test. Pooled success rates were estimated using a random-effects model, and mixed-effects meta-regression was used to assess the independent influence of clinical moderator variables. Thirteen studies (7 IMM, n=153; 6 AUT, n=189) were analyzed. At 12 months, the pooled success rate was 97.0% (95% CI: 93.7% - 100.0%) for IMM and 95.9% (95% CI: 90.1% - 100.0%) for AUT; the difference was not statistically significant (P = .880). At 36 months, the IMM group maintained a success rate of 97.0%, whereas the AUT group demonstrated a decline to 90.3% (95% CI: 77.2% - 100.0%), which also did not reach statistical significance (P = .217). No evidence of publication bias was detected at either interval (Egger's regression test: 12-month IMM: P = .755; AUT: P = .748; 36-month IMM: P = .755, AUT: P = .676). The provision of cuspal coverage was identified as a significant prognostic factor at 36 months (P = .015). Patient sex, age, and molar position did not significantly influence success rates (P > .05). A marginal negative association was observed with the use of wire splints at 12 months (P = .081). Both immediate implant placement and autotransplantation of mature teeth demonstrate high short- to mid-term success rates with no statistically significant difference observed between them and may represent viable treatment options for posterior teeth replacement. The provision of an indirect restoration with cuspal coverage is associated with higher 36-months success rates for autotransplanted teeth. Immediate implants and autotransplanted mature teeth demonstrate similar short- to mid-term success rates, supporting autotransplantation as a viable, biologically conservative alternative for posterior tooth replacement. However, the treatment modality should be based according to patient characteristics, donor tooth availability, anatomical considerations, clinician expertise, and restorative requirements.
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2. Injectable and retrievable calcium salicylate hydrogel promotes sustained periapical bone regeneration in a beagle dog model of apical periodontitis.
PMID:日期:2026-09-29Persistent apical periodontitis remains a clinical challenge requiring both effective disinfection and bone regeneration. This study tested the hypothesis that an injectable, retrievable F127-DMA/CASA hydrogel facilitates periapical bone healing by combining antimicrobial action with osteogenic induction. Periapical lesions were induced in 18 single-rooted teeth of two beagle dogs. After the periapical lesions were confirmed, teeth were randomly assigned to three groups: F127-DMA/CASA, Ca(OH), or an untreated control. For the CASA and Ca(OH)groups, intracanal medicaments were placed and then removed after 4 weeks; in the control group, the root canals were left without medicament. Periapical lesion volumes were tracked via cone-beam computed tomography and 3D volumetric analysis for up to 10 weeks post-medication. In vitro, human osteoblasts were exposed to the hydrogel to evaluate osteogenic marker expression by RT-qPCR and to characterize mineral deposition by spectroscopic analysis and electron microscopy. The F127-DMA/CASA group achieved the highest overall mean lesion volume reduction (54%) and significantly outperformed both control (26%) and Ca(OH) treatment (38%) at 10-weeks (p<0.03). Healing progressed at three different rates. The fastest occurred at 0-2 weeks, corresponding to initial cleaning of the canal, where Ca(OH) and CASA were similar to each other and only moderately faster than control. The Ca(OH) and control reached a plateau after two weeks, with only a small subsequent increase (10% and 6%, respectively) at week 10. In contrast, CASA continued to show a significantly higher rate (20%) between weeks 2 and 6, which slowed (6%) between weeks 6 and 10, but remained higher than Ca(OH) and control. A surprising result was the observation of new bone formation in two of the CASA-treated teeth. These results were further supported by auxiliary in vitro experiments in which osteoblasts exposed to CASA showed a 3- to 25-fold increase in mRNA levels of all targeted osteogenic markers and robust bone like mineral deposition. The F127-DMA/CASA hydrogel achieved superior, sustained periapical healing and demonstrated bone regeneration as compared with conventional medicaments in a clinically relevant animal model. These outcomes were supported in vitro, exposing the molecular upregulation of osteoblast maturation markers and deposition of bone analog minerals, suggesting the system functions as a bioactive regenerative therapy beyond traditional disinfection.
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3. Inflammatory Cytokines as Mediators of the Association Between Obesity and Chronic Apical Periodontitis.
3. 炎症细胞因子作为肥胖与慢性根尖周炎之间关联的介质PMID:日期:2026-09-29To assess genetic associations thatsupporta plausible causal interpretation of the obesity-chronic apical periodontitis (CAP) relationship, and to screen mediators including inflammatory cytokines, immune cell profiles and gut microbiota. Two-sample Mendelian randomization (MR) based on public obesity GWAS and FinnGen CAP data; two-step MR mediation analysis to validate mediation effects of inflammation, gut microbiota and immune cell phenotypes. An association between genetically elevated body mass index (BMI) and increased susceptibility to CAP (ukb-b-2303, OR = 1.298; 95% CI: 1.170-1.439;P= 7.521E-07; FDR = 9.025E-06) was identified, compatible with a plausible causal interpretation. To further characterize the underlying mechanisms, two-step MR mediation analyses were performed. Three inflammatory cytokines were identified as significant mediators of the BMI-CAP relationship: M-CSF levels (OR = 1.107; 95% CI: 1.027-1.193; P = 0.008; FDR = 0.016), IL-6 levels (OR = 1.158; 95% CI: 1.071-1.252; P = 2.476E-04; FDR = 0.001), and TNFSF12 levels (OR = 0.885; 95% CI: 0.819-0.955; P = 0.002; FDR = 0.005). However, gut microbiota traits and immune cell phenotypes showed no significant mediating effects on the BMI-CAP causal association. This MR analysis identified a genetically predicted association between obesity and CAP that appears to be mediated, at least in part, by inflammatory cytokines, supportive of a potential causal interpretation. These findings suggest weight management may represent a plausible strategy for the prevention and management of CAP.
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4. Insights Into the October 2026 Issue of the JOE.
4. 深入解读2026年10月刊《JOE》PMID:日期:2026-09-23该文献暂无摘要。
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5. Association Between C-Shaped Root Canal Configuration in Mandibular Second Molars and Radicular Grooves in Mandibular First Premolars: A CBCT-Based Study in a Western Chinese Population.
5. 中国西部人群下颌第二磨牙C形根管构型与下颌第一前磨牙牙根沟的关联：一项基于CBCT的研究PMID:日期:2026-09-23C-shaped root canal configurations (CSRCs) in mandibular second molars (MSMs) and radicular grooves (RGs) in mandibular first premolars (MFPs) are anatomical variations that may affect endodontic procedures. However, their relationship within the same individual remains unclear. This study investigated the association between CSRCs and RGs using CBCT in a Western Chinese population. This retrospective CBCT study enrolled 1,637 participants (682 males and 955 females), and a total of 3,274 MSMs and 3,274 MFPs were assessed. RGs in MFPs were evaluated using the Arizona State University Dental Anthropology Scoring System (ASUDAS), whereas CSRCs in MSMs were classified according to the Fan et al. classification system (C1-C5). Examiner reliability was assessed using Cohen's kappa and weighted kappa coefficients. The prevalence, configuration, and bilateral symmetry of CSRCs and the prevalence, configuration, anatomical location, severity, and bilateral symmetry of RGs were assessed. Cohen's kappa, weighted Cohen's kappa, and McNemar's test were used to assess agreement and bilateral symmetry. The association between CSRCs and RGs was examined using chi-square tests, Cramer's V, and univariable and multivariable binary logistic regression analyses. The multivariable model was adjusted for age group and gender, and a separate multivariable binary logistic regression model was performed to evaluate the associations of age group and gender with the co-occurrence of CSRCs and RGs. Statistical significance was set at p < 0.05. At the patient level, CSRCs in MSMs were identified in 46.0% of participants, with C3 being the most prevalent configuration. RGs in MFPs were identified in 38.2% of participants; the mesial surface was the most frequently affected location, and ASUDAS Grade 3 was the most common groove-positive grade. CSRCs and RGs demonstrated high bilateral symmetry, occurring symmetrically in 86.6% and 88.9% of participants, respectively. Both anatomical variations co-occurred in 21.6% of participants. CSRC presence was significantly associated with RG presence [χ(1) = 46.087, p < 0.001], with a weak effect size (Cramer's V = 0.168). After adjustment for gender and age group, patients with CSRCs had approximately 2.1 times the odds of exhibiting RGs compared with patients without CSRCs (adjusted OR = 2.092, 95% CI: 1.700-2.574, p < 0.001). Females had higher odds of exhibiting both anatomical variations, whereas participants aged 51-65 years had lower odds of co-occurrence than those aged 13-30 years. CSRCs in MSMs were significantly associated with RGs in MFPs. Although the underlying developmental relationship requires further investigation, the presence of a CSRC may provide useful adjunctive clinical information during endodontic assessment.
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6. Cytotoxicity and Genotoxicity of Newly Formulated Bioceramic Sealers: An In Vitro Study.
6. 新型生物陶瓷封闭剂的细胞毒性和遗传毒性：一项体外研究PMID:日期:2026-09-23Bioceramic sealers are used for their favorable biocompatibility, yet concerns remain regarding cytotoxicity and genotoxicity when extruded. Recently introduced sealers, C-Root SP (CSP) and BC Sealer Ion Plus (BCIP), incorporate formulations that enhance bioactivity. This study aimed to evaluate and compare the cytotoxicity and genotoxicity of CSP, BCIP, and EndoSequence BC Sealer (ESBC) in human periodontal ligament (hPDL) fibroblasts. HPDL fibroblasts were exposed to full strength and 1:10 dilution media conditioned with ESBC, BCIP, and CSP. Cytotoxicity was assessed using CellTox™ Green and CellTiter-Glo® assays. Genotoxicity was evaluated via immunofluorescence staining for γH2AX and 53BP1. Statistical analysis was performed using one-way or two-way ANOVA with statistical significance P < 0.05. At full concentration, CSP was significantly more cytotoxic than ESBC or BCIP (P < .05), with all three falling below the 70% ISO viability threshold. At 1:10 dilution, only CSP maintained cell viability comparable to untreated controls. No changes in cytotoxicity were observed for the 3 materials at full-strengths at 24, 48, and 72 hours (P > .05); however, at 1:10 dilution, ESBC cytoxicity was higher than CSP and BCIP at 72 hours . Immunofluorescence revealed significantly higher genotoxicity with full-strength ESBC compared to CSP and BCIP (P < .05); no significant genotoxic differences were observed at 1:10 dilution (P > .05). These findings highlight the importance of concentration-dependent effects when selecting bioceramic sealers for clinical use.
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7. Cemental Tear: A Multicenter Retrospective Case Series.
7. 牙骨质撕裂：多中心回顾性病例系列PMID:日期:2026-09-22Cemental tear (CeT) is an often-overlooked condition that may mimic endodontic and periodontal diseases, leading to misdiagnosis and inappropriate management. This multicenter study reports a series of CeT cases characterized using an integrated clinical, cone-beam computed tomography (CBCT)-based imaging, and tissue-based analytical approach. Twenty-nine teeth from 21 patients were diagnosed with CeT based on clinical and CBCT findings. Fragment location, root third distribution, and extent of the root surface and periradicular bone involvement were assessed. Extracted teeth and surgically removed fragments were subjected to micro-computed tomography, scanning electron microscopy, and histopathologic examination, depending on specimen availability. Demographic, clinical, and imaging variables were recorded and analyzed. CeT predominantly affected older adults (mean age, 66.5 years) and was most frequently observed in anterior teeth (96.6%). Cases presented with a history of dental trauma (41.4%), parafunctional habits (37.9%), and occlusal interference (31%). Radiographic examination failed to identify CeT in 72.4% of cases. CBCT demonstrated fragment detachment in 28 teeth (96.6%), while one case (3.4%) was diagnosed only during surgery. CeTs most frequently involved the apical and middle thirds of the root, with fragment thickness ranging from 0.23 to 0.81 mm and surface area from 0.59 to 28.42 mm. Histopathologic examination revealed acellular or cellular cementum associated with periodontal ligament remnants, fibrous connective tissue, chronic inflammation, and occasional cystic epithelial lining. Micro-computed tomography demonstrated abrupt margins, crater-like defects, and microfractures, while scanning electron microscopy showed irregular fragment planes, exposed periodontal fibers, and biofilm-like deposits.
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8. Radiologic and Immunohistochemical Correlation of Programmed Death 1/Programmed Death Ligand 1 and CD4+ T Cells in Periapical Granuloma and Radicular Cyst: An Observational Study.
8. 根尖肉芽肿和根尖囊肿中程序性死亡1/程序性死亡配体1与CD4+ T细胞的放射学及免疫组织化学相关性：一项观察性研究PMID:日期:2026-09-21This study quantitatively evaluated CD4 inflammatory cells, programmed death 1 (PD-1), and its ligand (PD-L1) in periapical granuloma and radicular cyst to elucidate their role in chronic periapical inflammation, and correlated marker expression with periapical index, severity of inflammatory infiltrate and cystic lining thickness. Eighty-one tissue samples comprising periapical granuloma (PG, n=27), radicular cyst (RC, n=27), healthy pulp (HP, n=14), and normal oral mucosa (NOM, n=13) were evaluated. Morphological and immunohistochemical analyses were performed to quantify CD4, PD-1 and PD-L1 expression with periapical index and histological inflammatory scores. Data were analyzed using non-parametric and Spearman correlation tests (p<.05). Mean CD4 expression was significantly higher in RC than PG (p < 0.05); both lesions demonstrated higher CD4 levels than HP and NOM (p < 0.05). Conversely, PD-L1 was significantly higher in PG than RC (p< 0.05), HP and NOM (p< 0.001). Notably, PD-1 expression was exclusively observed in PG (p < 0.05). Higher periapical index scores were associated with RC rather than PG (p< 0.001), and its comparison with PD-1 expression was significant (p< 0.001). Severe inflammation equally predominated in PG and RC (p> 0.05). In PGs, inflammatory score correlated significantly with CD4 expression (p= 0.006). PG exhibits a highly active immune microenvironment, and the observed expression of PD-1 and PD-L1 may indicate a potential role of the PD-1/PD-L1 checkpoint axis in modulating CD4T cell-associated inflammation. Conversely, the lack of detectable PD-1 in RC may suggest a divergence in regulatory pathways; however, alternative factors like low localized T-cell activation, sampling variability, or technical limits of detection cannot be excluded.
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9. Non-destructive Prediction of Remaining Useful Life for Nickel-Titanium Rotary Files Using Electrochemical Impedance Spectroscopy and Artificial Intelligence.
9. 利用电化学阻抗谱和人工智能对镍钛旋转器械剩余使用寿命的无损预测PMID:日期:2026-09-20Nickel-titanium (NiTi) rotary files are widely used in modern root canal therapy. Although instrument separation is relatively uncommon, sudden fatigue fracture may lead to serious clinical consequences. Current methods are limited to detecting macroscopic defects and cannot quantitatively assess early-stage microscopic fatigue damage. To address this issue, we combined electrochemical impedance spectroscopy (EIS) with artificial intelligence to develop a framework for the non-destructive prediction of the remaining useful life (RUL) of NiTi rotary files. We conducted EIS monitoring on 94 NiTi rotary files from their pristine state until fatigue fracture, and built a dataset containing 864 valid measurements. We designed a frequency point and sliding window joint optimization strategy to select key features and eliminate feature dimensionality redundancy. Using five-fold cross-validation, we evaluated 18 models: nine traditional machine-learning models, eight conventionally trained deep-learning architectures, and the pretrained tabular foundation model TabPFN; we established a three-level clinical risk-warning system. Among the evaluated models, CatBoost, a gradient-boosting decision-tree algorithm, achieved the lowest cross-validated mean absolute error (MAE; 0.133 ± 0.015) and a mean three-level risk-classification accuracy of 71.1% ± 2.9%. Furthermore, the joint optimization strategy reduced feature dimensionality by 83.0% without significantly compromising performance. Best-performing traditional machine-learning models outperformed conventionally trained deep-learning architectures and TabPFN on this small tabular dataset. This study confirms that an EIS- and AI-based non-destructive assessment method enables the quantitative evaluation of the fatigue state of NiTi rotary files prior to fracture, providing a clinically meaningful basis for personalized instrument replacement decisions.
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10. Congenital Morphology and Occlusion in Cracked Teeth: A Combined T-Scan and Finite Element Analysis.
10. 隐裂牙的先天性形态与咬合：T-Scan与有限元分析联合研究PMID:日期:2026-09-17To investigate the biomechanical characteristics of innate occlusal contact patterns in cracked teeth (CT) using T-Scan analysis combined with finite element analysis, and to establish a theoretical foundation for clinical prevention and restorative strategies. Twelve patients with cracked maxillary first molars exhibiting mesial marginal ridge cracks and twelve controls were enrolled. Occlusal contacts were recorded using T-Scan, with categorical variables analyzed via Fisher's exact test (P < .05). Patient-specific finite element models were constructed from the cone beam computed tomography data of 3 cracked and 3 intact maxillary first molars. Stress distribution under different loadings was compared using two-way analysis of variance (P < .05). T-Scan analysis demonstrated a significantly higher incidence of abnormal occlusal contact points in the CT group compared with controls (P < .05), along with bilateral occlusal imbalance. Finite element analysis revealed that maximum von Mises stress values on the mesial surfaces were consistently higher than those on the distal surfaces in the CT group under vertical loading (P < .05). Abnormal contact sites contributed to increased stress on the mesial surfaces in both CT and controls. A significant intergroup difference in maximum von Mises stress was observed on the mesial surfaces (P < .05), whereas no significant difference was detected on the distal surfaces. Patients with CT exhibited bilateral occlusal imbalance, characterized by abnormal occlusal contact points on the affected teeth. Congenital morphological discrepancies represent the primary etiologic factor for CT, whereas aberrant contact points further exacerbate crack progression. Early occlusal adjustment and crown-supported protection are recommended to compensate for underlying morphological abnormalities.