INTERNATIONAL JOURNAL OF CANCER国际癌症杂志
INTERNATIONAL JOURNAL OF CANCER(英文缩写 INT J CANCER),ISSN 0020-7136,eISSN 1097-0215,中文译名:国际癌症杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 7.316 | Q1 |
| 2022 | 6.400 | Q1 |
| 2023 | 5.700 | Q1 |
| 2024 | 4.700 | Q1 |
| 2025 | 4.900 | Q2 |
INTERNATIONAL JOURNAL OF CANCER 最新收录文献
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1. Spatial Transcriptomic Profiling Reveals a Fibroblast-Associated Extracellular Matrix Niche in KRAS G12C-Mutant Lung Adenocarcinoma Primary Tumors From Patients With Metastasis.
PMID:日期:2026-10-02KRAS G12C is the most common KRAS alteration in lung adenocarcinoma and has emerging therapeutic relevance. However, the spatial programs within primary tumors that accompany metastasis remain poorly understood. We profiled primary tumor tissues from four patients with KRAS G12C-mutant lung adenocarcinoma, including two without metastasis and two with metastasis, using 10× Visium spatial transcriptomics. Spatial clustering, differential expression, functional enrichment, and Robust Cell Type Decomposition (RCTD)-based deconvolution using a published non-small cell lung cancer (NSCLC) single-cell atlas were performed. Candidate pathway relevance was assessed in The Cancer Genome Atlas (TCGA) KRAS G12C-mutant lung adenocarcinoma cases, and functional validation was performed using fibroblast-tumor co-culture assays. Spatial analysis identified 18 transcriptionally distinct clusters across 14,351 spots. In this exploratory cohort, metastatic-primary tumors showed descriptive expansion of selected spatial domains and reduction of epithelial/alveolar-associated regions. Deconvolution suggested reduced AT2-like signals and increased fibroblast-associated features in metastatic-primary tumors. Stepwise filtering of group-level, compartment-level and cluster-supported genes identified a fibroblast-associated extracellular matrix remodeling module consisting of COL1A1, COL1A2, COL3A1, SPARC, POSTN, and VCAN. In TCGA KRAS G12C-mutant lung cancer, VCAN expression correlated with collagen formation, extracellular matrix degradation, and EMT marker signatures. In vitro, VCAN-overexpressing MRC-5 fibroblasts enhanced H358 invasion without markedly altering short-term proliferation. These exploratory analyses identified a fibroblast-associated extracellular matrix remodeling niche associated with metastatic status in KRAS G12C-mutant lung adenocarcinoma. These preliminary findings support further investigation of primary-tumor stromal reprogramming in larger spatially profiled cohorts and mechanistic models.
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2. Short-Term PM2.5 Exposure and Daily Cancer Mortality Across 47 Japanese Prefectures: A Nationwide Time-Stratified Case-Crossover Study, 2013-2022.
PMID:日期:2026-09-30Short-term exposure to fine particulate matter (PM2.5) is an established risk factor for cardiopulmonary mortality, but its acute association with cancer mortality remains poorly characterized. We examined associations between short-term PM2.5 fluctuations and daily all-cancer and site-specific mortality across all 47 Japanese prefectures from January 1, 2013, to December 31, 2022. Using a nationwide time-stratified case-crossover design, we fitted prefecture-specific conditional quasi-Poisson regression models and pooled the estimates by random-effects meta-analysis, expressing associations as the excess relative risk (ERR) per 10 μg/m increase in PM2.5 (lag 0-2 days). Sensitivity analyses varied lag structures, meteorological spline specifications, and co-pollutant adjustment. A 10 μg/m increase in short-term PM2.5 was associated with a 0.88% increase in all-cancer mortality (95% CI: 0.57-1.18; p < 0.001). The association was consistent across sex, age, and primary site (all interaction p > 0.40), with significant estimates for breast (ERR 2.06%), colorectal (1.06%), stomach (0.81%), and lung (0.77%) cancers. Associations attenuated with longer moving-average windows and were no longer statistically significant from lag 0-5 onward. A measurable fraction of cancer deaths was attributable to PM2.5 above the WHO 24-h guideline (15 μg/m), with the largest fractions tracking prefecture-specific coefficients rather than ambient concentration. These findings indicate that short-term PM2.5 exposure is associated with higher daily mortality across diverse cancer types in Japan, even at relatively low ambient levels. Because the individual-level effect size is small and attenuated to non-significance after adjustment for either NO or SO, these findings are best interpreted as supporting population-level air-quality measures rather than individual clinical intervention.
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4. Correction to "Comparisons of Blood, Upper Respiratory Tract and Gut Viromes From Patients With Lung Cancer and Healthy Persons".
4. 对“肺癌患者与健康人血液、上呼吸道和肠道病毒组的比较”的更正PMID:日期:2026-09-30该文献暂无摘要。
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5. Epigenetic Predictors of Smoking: External Validation and Association With Smoking-Related Cancer Risk.
5. 吸烟的表观遗传预测因子：外部验证及其与吸烟相关癌症风险的关联PMID:日期:2026-09-26Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm-based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm-based smoking predictors in a large sample of middle-aged and older Australians for (i) their accuracy and reliability, and (ii) their association with risk of smoking-related cancers. We used blood DNAm data from the Melbourne Collaborative Cohort Study to calculate six DNAm-based smoking predictors (EpiSmokEr, Elliott-183, McCartney-233, DNAmPACKYEARS, PCPACKYEARS, and mCigarette). Accuracy with respect to self-reported smoking pack-years (N = 2875, median age: 61 years) was assessed using Pearson's correlations, explained variance, and area under the curve (AUC). Reliability was assessed using intraclass correlation coefficients (ICCs) in 364 duplicated samples. Conditional logistic regression was used to assess associations with lung (N = 332) and urothelial (N = 426) cancer risk in two nested case-control studies. All smoking predictors showed excellent reliability (ICC > 0.9) and ability to distinguish current from never smokers (AUCs: 0.94-0.98), explaining 35%-50% variance of smoking pack-years. The predictors were positively associated with smoking-related cancer risk, with strongest adjusted associations observed for mCigarette with lung cancer (per SD, rate ratio [RR] = 2.18, 95% CI: 1.57-3.02) and for PCPACKYEARS with urothelial cancer (RR = 1.62, 95% CI: 1.27-2.07). This translated into prediction gains compared with models solely based on questionnaire-collected smoking variables. In middle-aged and older Australians, DNAm-based smoking predictors showed very good reliability and accuracy in predicting smoking exposure, and strong positive associations with smoking-related cancer risk beyond self-reported smoking information. This highlights their potential utility as an alternative or addition to self-reported smoking information for cancer risk stratification.
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6. Limited Assessment of Proportional Hazards Despite More Frequent Violations Identified in Updated Oncology Trial Analyses: Frequency, Patterns, and Statistical Implications.
6. 尽管在更新的肿瘤试验分析中发现更频繁的违规，比例风险假设的评估仍有限：频率、模式及统计学意义PMID:日期:2026-09-25Prior studies suggest that proportional-hazards violations (PHVs) occur in oncology randomized controlled trials (RCTs) and may affect conclusions, but evidence has largely focused on initial reports rather than updated analyses. We examined PH testing practices, frequency, patterns, and statistical implications of PHVs in updated oncology RCTs. We focused on oncology RCTs supporting US Food and Drug Administration approvals. Phase II-III oncology RCTs supporting FDA approvals between 2006 and 2025 were identified. Individual patient data were reconstructed from Kaplan-Meier curves. PHVs were assessed using Schoenfeld residuals. Treatment effects were analyzed with Cox proportional-hazards models, log-rank tests, MaxCombo, and restricted mean survival time difference (RMSD). Two hundred seventy endpoint comparisons (150 overall survival [OS], 120 non-OS) from 168 RCTs were included. PH testing dropped from 24.1% in initial reports to 11.5% in updates (McNemar p < 0.001). Although PH testing increased over the past decade in initial publications (Wald p < 0.001), no trend in updates (Wald p = 0.29). PHV frequency was numerically higher in updated than initial analyses (38.9% vs. 33.0%). Non-OS endpoints, metastatic settings, and immunotherapy or targeted-therapy regimens were associated with PHVs. Among updated analyses, nominal significance differences between PH-dependent and alternative methods were more frequent with PHVs (MaxCombo: 11.4% vs. 3.6%, chi-square p = 0.012; RMSD: 8.6% vs. 2.4%, chi-square p = 0.021). PHV patterns were diminishing effects (35.2%), delayed separation (27.6%), and crossing hazards (27.6%). PH testing declined in updated analyses despite numerically more frequent PHVs. Although updates are descriptive and do not invalidate original conclusions, unrecognized non-proportionality may affect long-term benefit interpretation, supporting PH diagnostics and prespecified complementary analyses.
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7. Improved Prediction of Colon Cancer Recurrence Using the ColoNode mRNA Test: A 5-Year Survival Analysis.
7. 使用ColoNode mRNA检测改进结肠癌复发预测：一项5年生存分析PMID:日期:2026-09-25Twenty-five percent of colon cancer patients having curative surgery will recur. Most of them will die from distant metastasis partly due to shortcomings of routine histopathological analysis, that is, undetected tumor cells in the regional lymph node field. We have developed ColoNode, an mRNA test in which five biomarkers are quantified and related to a house-keeping gene. Thereby, four different risk groups are defined from low to very high-risk of recurrence being highly valuable as various indicators of the risk of occult tumor cell dissemination and their aggressiveness. Here we report results of the 5-year survival analysis of a prospective study involving nine Swedish hospitals comparing ColoNode with routine histopathology. The study involves 186 colon cancer patients. The following four conclusions can be drawn: (1) ColoNode surpassed histopathology by identifying all 20 patients who were found by histopathology and an additional seven patients who recurred. Multivariate analysis provided a hazard ratio of 6.7 (p = 0.002) while histopathology lost its significance (HR: 1.3; p = 0.60). Only perineural invasion remained as an independent risk factor apart from ColoNode, with a hazard ratio of 2.7 (p = 0.038). (2) Patients belonging to medium-risk group apparently benefited from adjuvant chemotherapy treatment. (3) A total of 113 patients (≈60%) belonged to the low-risk group and can be considered cured by surgery alone. (4) Four patients were missed by both ColoNode and histopathology. Possible reasons for this are discussed. The results suggest that the ColoNode test should be added to the arsenal of prognostic tools, maybe even replacing histopathological lymph node analysis.
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8. Randomized Prospective Comparison Between Neoadjuvant Mitomycin C Plus Cisplatin and Paclitaxel Plus Carboplatin in Patients With BRCA1-Associated Ovarian Cancer.
8. BRCA1相关性卵巢癌患者中新辅助丝裂霉素C联合顺铂与紫杉醇联合卡铂的随机前瞻性比较PMID:日期:2026-09-25Neoadjuvant mitomycin C plus cisplatin (MP) previously demonstrated promising activity in high-grade serous ovarian cancer in a single-arm study of BRCA1 pathogenic variant (PV) carriers. This prospective, open-label, randomized Phase II trial (NCT04747717) compared MP with standard paclitaxel-carboplatin (TCbP) in women with germline BRCA1/2 PVs. Here, we report a per-protocol analysis of the BRCA1 subgroup involving 29 MP and 31 TCbP patients. Grade III-IV anemia and thrombocytopenia were more frequent with MP, while other adverse events showed similar distribution. RECIST v1.1 response rates did not differ between treatment arms. Surgery was undertaken for 25 MP and 28 TCbP patients. Complete cytoreduction was achieved in 20/25 (80%) MP and 19/28 (68%) TCbP cases. All MP patients underwent complete debulking after 3-4 neoadjuvant cycles, while six out of 19 women from the TCbP arm required more than 4 cycles to achieve surgical clearance of tumor lumps (p = 0.008). MP outperformed TCbP in the improvement of the peritoneal cancer index (p = 0.001). Complete absence of tumor cells in the omentum was documented in 4/25 (16%) MP patients and 6/28 (21%) TCbP patients (p = 0.73). Maintenance olaparib, complete cytoreduction, resolution of carcinomatosis, and TP53 mutation type (loss-of-function (LOF) versus non-LOF) were associated with improved disease-free interval (DFI). At a median follow-up of 44.8 months, multivariate analysis revealed no differences in progression-free survival or DFI between treatment arms. In conclusion, MP showed no significant efficacy advantage over TCbP but produced a rapid and profound reduction of tumor burden, thus warranting further evaluation. Trial Registration: ClinicalTrials.gov (identifier: NCT04747717).
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9. Lifestyle Factors Associated With Colorectal Adenomas: Results From a Vietnamese Case-Control Study.
9. 与结直肠腺瘤相关的生活方式因素：一项越南病例对照研究的结果PMID:日期:2026-09-24Although colorectal cancer (CRC) is the fourth most common cancer in Vietnam, evidence on lifestyle factors associated with colorectal adenomas (CRA) remains limited. We conducted a case-control study to examine lifestyle factors associated with CRA. Conditional logistic regression (CLR) was performed using 845 matched case-control pairs. Structural equation modeling (SEM) and propensity score matching (PSM) analyses were conducted using the full sample of 847 cases and 1201 controls. CLR identified heavy alcohol consumption (OR 1.59, 95% CI: 1.13-2.23), current smoking (OR 1.88, 95% CI: 1.28-2.76), a personal history of colorectal polyps (OR 7.02, 95% CI: 4.02-12.27), and a sibling history of CRC (OR 3.33, 95% CI: 1.23-9.03) as risk factors for overall adenomas. A personal history of colorectal polyps was associated with both advanced and non-advanced adenomas, whereas current smoking and heavy alcohol consumption were associated with advanced but not non-advanced adenomas. SEM and PSM generally corroborated the CLR findings, with heavy alcohol consumption, current smoking, and a personal history of colorectal polyps associated with advanced adenomas. PSM additionally suggested a possible positive association between high meat consumption and advanced adenomas. CLR identified an inverse association between a beverage pattern characterized by coffee, black tea, and fruit juice consumption and adenoma prevalence; however, this finding was not confirmed in PSM. In conclusion, current smoking, heavy alcohol consumption, and a personal history of colorectal polyps were consistently associated with an increased risk of CRA, particularly advanced adenomas. These findings support lifestyle-focused prevention strategies and risk-stratified CRC surveillance in Vietnam.
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10. Gene Expression Biomarkers for Breast Ductal Carcinoma in Situ Recurrence Prediction.
10. 乳腺导管原位癌复发预测的基因表达生物标志物PMID:日期:2026-09-24Breast ductal carcinoma in situ (DCIS) is often overtreated due to a lack of robust prognostic and predictive tools. This study aimed to evaluate gene expression in a well-characterised DCIS cohort to determine their clinical utility as biomarkers for ipsilateral recurrence. RNA was extracted from microdissected tissues from primary DCIS. A 129-gene panel was analysed using NanoString in 174 DCIS cases (131 with no recurrence and 43 with recurrence). Association with recurrence was determined by Cox regression analyses. Validation was performed by immunohistochemistry. A new 7-gene panel (PBK, COL1A2, GSTM5, MMP2, MX1, SLC22A3 and ZEB1) was derived from the NanoString data but could not be validated in external datasets, including when stratified by radiotherapy treatment. Increased expression of ZEB1 alone was consistently significantly associated with longer recurrence-free survival in discovery and validation cohorts (hazard ratios 0.56-0.71). Correlation between mRNA and protein expression showed the strongest association with peri-ductal fibroblast expression. However, there was no association of ZEB1 protein expression in these cells with recurrence in an independent cohort. Existing multigene panels showed inconsistent associations with recurrence in the current cohort. Gene expression panels show limited reproducibility across cohorts, highlighting the need for prospective trials and context-specific validation. ZEB1 mRNA emerges as a potential biomarker warranting further investigation for its clinical utility in guiding management decisions in DCIS.