JOURNAL OF NUTRITION营养学杂志
JOURNAL OF NUTRITION(英文缩写 J NUTR),ISSN 0022-3166,eISSN 1541-6100,中文译名:营养学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.735 | Q2 |
| 2022 | 4.200 | Q2 |
| 2023 | 3.700 | Q2 |
| 2024 | 3.800 | Q2 |
| 2025 | 4.200 | Q2 |
JOURNAL OF NUTRITION 最新收录文献
-
2. Maternal and Embryonic Vitamin D3 Supplementation Improves Hepatic Lipid Metabolism in Progeny Chicks.
PMID:日期:2026-09-23For oviparous laying hens, transition into the late laying phase tends to be associated with reduced nutrient deposition in eggs. Accordingly, maternal dietary and in ovo supplementation of essential nutrients to eggs from late-phase hens could effectively improve embryonic development and even the subsequent performance of the offspring. To date, it remains unclear whether vitamin D3 (VD3) exerts functions beyond calcium and phosphorus homeostasis to mediate the link between maternal nutrition and offspring metabolic regulation. This study aimed to investigate the effects of maternal and embryonic VD3 supplementation on hepatic lipid metabolism in progeny chicks, and to elucidate the underlying molecular mechanisms. Eggs collected from hens at the peak-laying phase and late-laying stage were incubated to compare differences in hepatic lipid metabolism of their progeny. VD3 was administered via either in ovo injection or maternal dietary supplementation to determine its regulatory effects on the hepatic lipid metabolism of the offspring. Primary chicken hepatocytes were treated with 1,25(OH)D3, with or without the presence of VDR-shRNA lentivirus or a PPARα antagonist. Progeny derived from late-laying hens exhibited significantly higher hepatic lipid deposition than those from peak-laying hens, accompanied by coordinated downregulation of VDR expression and the transcriptional programs governing fatty acid β-oxidation and lipid transport. Both in ovo injection and maternal dietary supplementation of VD3 effectively alleviated these adverse alterations in the progeny of late-laying hens. In vitro experiments further demonstrated that 1,25(OH)D3 upregulated the transcription of PPARα and HNF4α in a VDR-dependent manner, which subsequently enhanced the expression of genes related to fatty acid oxidation and lipid transport, respectively. VD3 supplementation, either at the maternal or embryonic level, improves hepatic lipid metabolism in progeny chicks by enhancing fatty acid oxidation and lipid transport, primarily through activation of the VDR-PPARα/HNF4α signaling pathway.
-
3. AI/ML-Enabled Precision Nutrition Modestly Improves Anthropometric Outcomes and Systolic Blood Pressure: A Systematic Review and Meta-Analysis.
3. 基于人工智能/机器学习的精准营养适度改善人体测量学结果与收缩压：一项系统综述与荟萃分析PMID:日期:2026-09-23Precision nutrition tailors dietary guidance to individual biological, genetic, metabolic, and behavioral characteristics. Artificial intelligence (AI), machine learning (ML), wearables, sensors, mobile apps, and multi-omics tools increasingly support this approach, but evidence on their effectiveness, feasibility, implementation, and equity remains fragmented. This review evaluated the effectiveness of AI/ML-enabled analytical approaches and technologies in precision nutrition across dietary, metabolic, behavioral, implementation, and equity outcomes. We conducted a PRISMA-guided systematic review and meta-analysis of studies published from January 2015 to December 2025 across six databases. Eligible studies examined AI/ML, digital tools, wearables, mobile platforms, or multi-omics approaches for personalized nutrition across the lifespan. Two reviewers independently screened studies, extracted data, and assessed bias. Random-effects meta-analyses were conducted where outcomes were comparable; remaining studies underwent qualitative and thematic synthesis. Overall, 262 studies met the inclusion criteria. Meta-analyses indicated modest pooled reductions in body weight (-1.97 kg), BMI (-0.57 kg/m), waist circumference (-2.41 cm), and systolic blood pressure (-4.05 mmHg), whereas no significant pooled effects were observed for lipid outcomes or glycemic markers. Corresponding 95% confidence intervals and 95% prediction intervals were -3.02 to -0.92 and -6.69 to 2.75 kg for body weight, -0.99 to -0.15 and -2.43 to 1.29 kg/m for BMI, -4.75 to -0.07 and -11.30 to 6.49 cm for waist circumference, and -6.90 to -1.19 and -13.24 to 5.15 mmHg for systolic blood pressure. Dietary intake outcomes were generally small and inconsistent, although vegetable intake showed a modest improvement. Certainty of evidence was generally low to very low because of risk-of-bias concerns, imprecision, and substantial heterogeneity; prediction intervals for several statistically significant pooled effects crossed the null. Subgroup findings were exploratory and underpowered. Technology-enabled precision nutrition may modestly improve anthropometric outcomes and systolic blood pressure, but longer, well-reported studies are needed to clarify the clinical impact of precision nutrition technologies. SYSTEMATIC REVIEW REGISTRATION: This review was registered with PROSPERO under registration number CRD420251241063.
-
4. Protein and the 2025-2030 Dietary Guidelines for Americans: The Right Number… But the Right Process?
PMID:日期:2026-09-22该文献暂无摘要。
-
5. EAT-Lancet Diet-Associated Serum Metabolites Are Linked to Cardiovascular Disease and Mortality.
PMID:日期:2026-09-22Higher adherence to the EAT-Lancet diet is associated with lower risk of cardiovascular disease (CVD) and all-cause mortality. Metabolomic profiling can identify biomarkers underlying these associations. To investigate metabolomic markers of the EAT-Lancet diet and risk of CVD and all-cause mortality. We analyzed two independent subgroups of Atherosclerosis Risk in Communities (ARIC) study participants (n=1,594, n= 1,776) with serum metabolomic data at visit 1 (1987-1989). Adherence to the EAT-Lancet diet was assessed using the Planetary Health Diet Index (PHDI), calculated from a 66-item food frequency questionnaire. Multivariable linear regression models were used to identify metabolites associated with the PHDI score. Cox proportional hazards regression models were used to assess the associations of each doubling in PHDI-related metabolite levels with incident CVD and all-cause mortality. Estimates were meta-analyzed across subgroups using fixed-effects regression, with follow-up through December 31, 2022. We accounted for multiple comparisons using the Bonferroni method in the cross-sectional analysis and using the false discovery rate in the prospective analysis. Twenty-nine (23 positively and 6 inversely) out of 359 metabolites were associated with PHDI score. During a median follow-up of 24 years for CVD and 29 years for mortality 1,352 incident CVD cases and 2,088 deaths occurred. Four PHDI-related metabolites were associated with incident CVD or all-cause mortality. Glycerate was associated with lower risks of these outcomes (incident CVD HR = 0.89, 95% CI 0.82-0.96; all-cause mortality HR = 0.86, 95% CI 0.81-0.91). Indolepropionate was linked to lower risk of all-cause mortality and 1-docosahexaenoylglycerophosphocholine (22:6n3) was associated with lower risk of incident CVD. O-methylcatechol sulfate was positively associated with both outcomes. In a community-based cohort of US adults, 29 metabolites were associated with PHDI score. Four of these metabolites were associated with incident CVD or all-cause mortality, highlighting potential mechanisms of the health impacts of the EAT-Lancet diet.
-
6. A MIND-Based Diet With or Without Digital Cognitive Training Improves Cognitive Function and Nutritional Status in Older Adults With Mild Cognitive Impairment.
PMID:日期:2026-09-22Given the growing prevalence of mild cognitive impairment (MCI) among the aging population, there is a critical need for multifaceted lifestyle interventions that combine nutritional support with cognitive stimulation to prevent further decline. This study aimed to evaluate the effects of a cognitive function improvement management diet (Diet), with or without a digital cognitive enhancement program (SUPERBRAIN for group; SG), on cognitive function in adults aged 65 years or older with MCI attending daycare centers. This 12 week cluster-randomized controlled trial included 80 older adults. Participants were assigned to a dietary intervention group (Diet, n = 33), a combined dietary and program intervention group (Diet+SG, n = 28), or a control group (n = 19) in an open-label trial. The MIND-based diet was provided to the Diet and Diet+SG groups as meals and snacks five days per week. Assessments included anthropometry, physical measurements, blood parameters, nutritional indices, quality of life, activities of daily living, and cognitive function. Cognitive outcomes were evaluated using the Korean Mini-Mental State Examination 2 and the Clinical Dementia Rating. Compared with the control group, both the Diet and Diet+SG groups showed significant improvements in nutritional status (NQ-E, p < 0.001), quality of life (EQ-5D-5L, p < 0.001), activities of daily living (K-ADL, p < 0.001; K-IADL, p < 0.001), and cognitive function (K-MMSE2, p < 0.001). Improvements in average and maximum muscle strength (p < 0.001), indicators of frailty, were observed only in the Diet+SG group compared with the control group. These findings suggest that adults with MCI may derive benefits from the combined application of a cognitive function improvement management diet and a digital cognitive enhancement program. Clinical Research Information Service (CRIS) with registration number KCT0009528.(https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=L&pageSize=10&page=undefined&seq=27374&status=5&seq_group=27374).
-
7. Dietary Patterns Are Key Predictors of Cardiovascular Risk Beyond Genetic Risk Across Metabolic Syndrome Trajectories in A Korean Prospective Cohort Study.
PMID:日期:2026-09-22Metabolic syndrome (MetS) progression involves distinct trajectory states, including newly-developed (ND-MetS), recovered (R-MetS), and persistent MetS (P-MetS), each associated with different cardiovascular disease (CVD) risk profiles. The transition to incident MetS represents a critical window for early dietary intervention, as subclinical metabolic deterioration often precedes clinical recognition. However, the predictive value of dietary quality relative to biochemical and genetic markers within integrated machine learning frameworks remains poorly characterized in longitudinal cohorts. This study aimed to develop and evaluate machine learning-based prediction models integrating dietary quality indices, biochemical markers, and genetic variants for CVD risk stratification across MetS trajectory groups in a large Korean prospective cohort. We analyzed 58,701 Korean adults from the Korean Genome and Epidemiology Study with a 5-year follow-up, classified into four MetS trajectory groups: N-MetS (no MetS; n=46,647), ND-MetS (n=3,505), R-MetS (n=5,307), and P-MetS (n=3,242). Cox proportional hazards models established CVD risk across trajectory groups, identifying ND-MetS as the highest-risk population. Random forest and extreme gradient boosting(XGBoost) models were then developed to evaluate the predictive contributions of dietary patterns, Modified Korean Healthy Eating Index scores, biochemical markers, and genetic variants. ND-MetS was positively associated with incident CVD risk (HR=1.87, 95% CI: 1.23-2.67) compared with N-MetS. Excluding MetS component variables to avoid circularity, the random forest model achieved the best predictive performance (AUC=0.756), outperforming XGBoost (AUC=0.731). Key predictors included hepatic enzymes (γ-GTP, ALT, AST), inflammatory markers (hs-CRP), dietary patterns, and anthropometric measures. The genetic risk score of the APOA4-APOA5-ZPR1-SIK3-APOC3 cluster consistently ranked below dietary patterns (reflecting diet quality) and biochemical markers in predictive importance across all machine learning models. Machine learning models integrating dietary quality indices with routine biochemical markers improved CVD risk stratification in ND-MetS beyond genetic approaches alone, offering a practical, scalable, and genotype-independent precision nutrition strategy for Korean adults.
-
8. Vitamin D Deficiency Is Associated with Increased Uterine Fibroid Risk: A Systematic Review and Meta-Analysis.
PMID:日期:2026-09-22Uterine fibroids, the most common benign tumors in women of reproductive age, are the leading cause for hysterectomies and disproportionately affect African American women. This is an updated systematic review that performs a novel meta-analysis of observational studies to quantify the association between serum vitamin D levels and uterine fibroids across a wide range of studies. Additionally, a comprehensive review is included on vitamin D-related factors in both preclinical and clinical studies to assess vitamin D's efficacy in treatment and prevention. Cochrane Library, Embase, PubMed, Scopus, and Web of Science were searched for publications from inception to April 2024. Risk of bias was assessed using Cochrane RoB 2.0 and the Newcastle-Ottawa Scale. Statistical analysis was conducted using R software and the use of a random effects model with restricted maximum-likelihood estimated the overall effect. Sixty-nine studies met the inclusion criteria and were categorized as preclinical (n=26) or clinical (n=43). One preclinical study explored downregulation of vitamin D receptors as a mechanism for pathogenesis; others reported a link between vitamin D-related polymorphisms and increased risk of fibroids. Twenty-nine clinical studies evaluated hypovitaminosis D and fibroid prevalence; twenty-six confirmed an association, while three found no significant differences. Analysis of 21 clinical studies found a large negative effect size (Mean Difference = -5.90ng/mL; I = 97.4%; p < 0.001), indicating that women with fibroids had markedly lower vitamin D levels compared to controls. Supplementation was shown to improve fibroid-associated symptoms in nine clinical interventional studies, with some demonstrating a reduction in fibroid size and others showing prevention in fibroid progression. The data supports a promising role for vitamin D supplementation in regulating fibroids and highlights the need for further clinical investigation of vitamin D as a potential alternative therapy. PROSPERO REGISTRATION: CRD420261320154, 20 Feb 2026.
-
9. Lactiplantibacillus plantarum YZ2 immersion reduces chloramphenicol residues in common carp (Cyprinus carpio).
9. 植物乳杆菌YZ2浸泡可降低鲤鱼（Cyprinus carpio）中的氯霉素残留PMID:日期:2026-09-19The antibiotic toxicity and risks associated with their residues pose a serious threat to food safety. The aim of this study is to investigate the mechanism by which probiotic immersion reduces antibiotic residues in common carp. A chloramphenicol (CAP) enrichment model was established in common carp (Cyprinus carpio), followed by screening for CAP-depleting strains from six candidate Lactobacillus strains. A total of 270 Carp (50.01±1.12 g) were then immersed with screened strains for 14 days. CAP residues in tissues and water were monitored using High-Performance Liquid Chromatography (HPLC). Hepatic Phase I/II enzymes, ATP-binding cassette (ABC) transporters, antioxidant enzymes and cytokines were analyzed via enzyme-linked immunosorbent assay (ELISA) and reverse transcription quantitative real-time PCR (RT-qPCR). The involvement of the nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway in CAP elimination and flesh quality improvement was further validated using the NRF2 activator sulforaphane and the inhibitor VVD-130037. Data were subjected to one-way analysis of variance (ANOVA) or Student's t-test to determine statistical significance. Natural recovery failed to clear CAP residues within 14 days. In contrast, Lactiplantibacillus plantarum YZ2 immersion significantly accelerated CAP elimination, reducing hepatic and muscular residues by 42% and 38% at day 7, respectively (P<0.05). Mechanistically, YZ2 activated the hepatic NRF2 signaling pathway, which coordinately upregulated Phase I/II enzymes (e.g., cytochrome P450 (CYP) 3A-like, UDP-glucuronosyltransferase [UGT]-family) and ABC transporters (e.g., abcb3, abcb4), enhancing systemic excretion. Pharmacological activation of NRF2 mimicked YZ2's effects, reducing residues (P<0.01) and mitigating oxidative stress (total antioxidant capacity [T-AOC] increased by 35%, P<0.05), while NRF2 inhibition abrogated these protective benefits. Furthermore, YZ2 enhanced flesh quality by upregulating myogenic regulatory factors (myf5, myod1, myog) and collagen genes (col1a1a, col1a2) (P<0.05), leading to a 22% increase in myofiber density. These findings demonstrate that L. plantarum YZ2 facilitates antibiotic depletion and improves muscle quality through an NRF2-mediated hepatic biotransformation and tissue-specific clearance.
-
10. The association between the Global Diet Quality Score and all-cause mortality in Black South African adults.
PMID:日期:2026-09-19Modifiable risk factors for cardiovascular diseases (CVD) include diet quality. The Global Diet Quality Score (GDQS) was designed to provide a comprehensive diet quality assessment, yet very few studies have assessed its relationship with CVD and all-cause mortality, particularly in an African setting. We determined the association between the baseline total GDQS, GDQS positive (GDQS+) and GDQS negative (GDQS-) and all-cause and CVD mortality after 13 years of follow-up in Black South African adults (aged 30 to 70 years). GDQS+ reflects healthy food intake, while GDQS- is reverse-scored (higher scores indicating lower intake of unhealthy foods). Across all GDQS measures, higher scores indicate better diet quality. The baseline dietary data from the PURE-NWP-SA study was used to calculate the GDQS, with mortality outcomes recorded 13 years later. Cox proportional hazards models were applied, stratified by sex, age group and observation time tertiles. Models were adjusted for lifestyle factors and health status. Hazard ratios (HRs) were calculated for baseline GDQS tertiles. The overall GDQS was low in both survivors and non-survivors, reflecting low intake of many GDQS healthy food groups, with only whole grains and liquid oils reaching desirable levels (to give maximum points to the GDQS+). Compared with Tertile (T1), participants in T3 of the GDQS+ had a lower risk of all-cause mortality (HR = 0.69; 95% CI: 0.56-0.86), whereas those in T3 of the GDQS- had a higher risk (HR = 1.39; 95% CI: 1.12-1.73). No associations were found with CVD mortality. The GDQS is a valuable tool for investigating all-causes mortality risk in African populations through its GDQS+ sub-metric. However, caution is warranted when applying the GDQS in settings of dietary monotony or food insecurity, particularly the GDQS- sub-metric which gives maximum points for low intake/avoidance of unhealthy food groups.