INTERNATIONAL JOURNAL FOR PARASITOLOGY国际寄生虫学杂志
INTERNATIONAL JOURNAL FOR PARASITOLOGY(英文缩写 INT J PARASITOL),ISSN 0020-7519,eISSN 1879-0135,中文译名:国际寄生虫学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.330 | Q1 |
| 2022 | 4.000 | Q1 |
| 2023 | 3.700 | Q1 |
| 2024 | 3.200 | Q1 |
| 2025 | 3.300 | Q1 |
INTERNATIONAL JOURNAL FOR PARASITOLOGY 最新收录文献
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1. Comparative proteomics reveals a conserved core of tegumental proteins in parasitic flatworms.
PMID:日期:2026-09-02Parasitic flatworms, including cestodes and trematodes, are covered by a specialized syncytial tegument that mediates nutrient uptake and host-parasite interactions. While the tegument of trematodes has been extensively characterized, its molecular composition in cestodes remains largely unknown. In this work, we performed a comparative proteomic analysis of the tegument of three cestode species, including larval and adult stages: Hymenolepis microstoma, Mesocestoides corti (syn. M. vogae) and the human pathogen Echinococcus multilocularis. Using stringent enrichment criteria relative to whole-worm extracts, we identified hundreds of tegument-enriched proteins in each species. Comparative analyses revealed a conserved core of tegumental proteins shared among all three species, including members of the Tegument Allergen-Like (TAL) family, vesicular trafficking components and calcium-sensing proteins, and identified candidates for nutrient uptake activities such as glucose and nucleoside transporters. Further comparative analyses revealed a set of shared tegumental proteins with the trematode Schistosoma mansoni, including conserved proteins that are specific to parasitic flatworms, supporting the existence of a conserved ancestral tegumental proteome. Finally, we confirmed tegumental expression of several genes in H. microstoma and E. multilocularis, and demonstrated regionally restricted gene expression among tegumental cytons, suggesting functional specialization within the syncytial tegument. Altogether, these results reveal an evolutionarily conserved composition of the tegument of parasitic flatworms, providing a foundation for future work targeting this critical host-parasite interface.
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2. Lineage differentiation in the cosmopolitan molluscan protozoan parasite Perkinsus olseni based on metabolic, molecular and morphological traits.
PMID:日期:2026-09-01The protozoan parasite Perkinsus olseni actively proliferates within marine molluscan hosts and causes serious negative effects on mollusk production worldwide. Recent research revealed that one Japanese isolate requires exogenous glycine betaine (GB) for vegetative proliferation, whereas isolates from some congeneric species do not, suggesting that this requirement is a derived characteristic of this genus. In the present study, we established various isolates from Japan, Europe, and Oceania, and showed that P. olseni isolates from Japan and Europe commonly require exogenous GB, whereas Oceanian isolates do not. This suggests that Oceanian isolates may retain ancestral-like characteristics compared to Japanese and European isolates. Analyses of the non-transcribed spacer region of ribosomal DNA further support the above interpretation that the Oceanian isolates represent a more basal split, and additionally suggest that the Japanese and European isolates belong to lineages that have undergone relatively recent geographic expansion. Morphological comparisons among isolates showed that the Oceanian isolates possessed larger schizonts and trophozoites, producing fewer daughter cells, but formed larger hypnospores capable of producing a greater number of zoospores, although the association between GB requirements and morphological differences remains unknown. The present study demonstrates the existence of distinct lineages of this parasite and provides novel insights into the evolution, geographical dispersion, and shifts in life-history strategies of P. olseni.
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3. Testing the "niche centroid hypothesis" in flea-mammal networks from the palearctic: species' centrality across their environmental niches.
PMID:日期:2026-09-01A species' centrality in a network is expected to decrease with distance from the centroid of its environmental niche. We investigated the variation of a species' centrality in flea-mammal networks across the space of its niche for 30 flea and 21 small mammal species occurring in 10-46 networks from different localities in the Palearctic. We characterized the environmental niche of a flea or a host species using the ellipsoid envelope model, based on a species' occurrence points and climatic, soil, and vegetation data. We found significant relationships between centrality in a network and the distance from the centroid of environmental niche in 14 of 30 flea species. In seven of these species, the centrality in a network either increased or decreased with an increase in the distance from the environmental centroid. In another seven species, the pattern was either U-shaped or inverted U-shaped. Among 20 host species, significant centrality-niche centroid relationships were found in only two species, being either linear with a positive slope or quadratic with a negative slope. We explain the lack of a general tendency of flea and host species' centrality in flea-host networks to decrease with an increase in the distance from the environmental niche centroid by the variable effects of species-specific life history traits. We also conclude that the most likely reason behind the difference between fleas and hosts in the occurrence of this tendency is their differential functions in the networks (consumers versus resources, respectively).
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4. Integrating age-dependent pig susceptibility and spatial exposure heterogeneity improves agent-based modeling of Taenia solium transmission.
PMID:日期:2026-09-01Taenia solium causes an estimated 2.8 million disability-adjusted life years annually and substantial economic burdens in endemic regions. Understanding pig infection dynamics is essential for control, yet age-dependent susceptibility, acquired immunity, and spatially heterogeneous exposure are rarely represented in transmission models. We integrated experimental infection data across pig age groups into a local-scale agent-based model (ABM) of T. solium transmission. The model includes age-related susceptibility peaking at weaning, immunity elicited by egg exposure, and heterogeneous pig-environment interactions derived from GPS-tracked movements. We compared four model configurations: baseline, immunity only, exposure heterogeneity only, and combined. Calibration and validation used human taeniasis and pig cysticercosis prevalence data from eight rural Peruvian villages; intervention scenarios included mass vaccination and anthelmintic treatment. All configurations fit observed data well, but models incorporating heterogeneous susceptibility concentrated 95% of infections before 6.5 months (versus distributed across lifespan in baseline). The combined model best reproduced empirical cyst burden distributions, with 2.2% of pigs harboring 87% of total cysts, approaching the observed 99.2% aggregation. Immunity attenuated post-intervention prevalence rebounds. Mass pig vaccination reduced pig cysticercosis prevalence by 16% in models without immunity but had negligible effect when immunity was included, indicating age-targeted interventions are essential; lower age cut-off needs maternal immunity data for cost-effective control. Integrating pig immunity and exposure heterogeneity improves T. solium transmission model realism and provides a more accurate framework for intervention design and evaluation.
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5. The application of ultrastructure expansion microscopy reveals the apical microtubule architecture of Babesia.
PMID:日期:2026-09-01Tick-transmitted apicomplexan parasites of the genus Babesia infect vertebrate red blood cells and cause babesiosis in humans and animals. Detailed studies of their subcellular organization have been constrained by their small size and intracellular development. In this study, we report the identification of a previously unrecognized apical tubulin rosette (ATRo) in Babesia divergens - a unique rosette-like microtubule structure located at the apical pole of the parasite. The ATRo consists of 6-7 radial spines and represents a distinct architecture that appears morphologically different from the conoid of Toxoplasma and the apical polar rings described in Plasmodium. This discovery was enabled by applying Ultrastructure Expansion Microscopy (U-ExM) to Babesia. U-ExM achieved a 4.3-fold isotropic expansion of the parasite and allowed nanoscale visualization of internal structures using conventional fluorescence labeling and standard confocal microscopy. Using tubulin-specific antibodies, we obtained preliminary insights into the tubulin architecture of the B. divergens apical end. U-ExM provided resolution comparable to transmission electron microscopy (TEM), while offering easier sample preparation, higher throughput and compatibility with proteomic markers, including multiplex immunostaining. These findings establish U-ExM as a powerful new tool for studying Babesia ultrastructure and developmental dynamics and offer a new entry point for exploring invasion mechanisms and potential therapeutic targets.
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6. The spatial distribution of dispersal-phase adult Varroa destructor mites on two strains of the honey bee (Apis mellifera) in New Zealand.
PMID:日期:2026-09-01The ectoparasite Varroa destructor (hereafter Varroa) poses a major threat to Western honey bee, Apis mellifera, populations. Synthetic chemical mite control treatments can have negative effects on bee health and are becoming less effective as mites develop pesticide resistance. A deeper understanding of the behaviour and adaptations of Varroa, and its interactions with A. mellifera, may aid in designing mite control strategies. This study investigates the host-parasite dynamics of A. mellifera and Varroa by examining the spatial distribution of adult dispersal-phase mites on a Varroa-susceptible strain and a Varroa-resistant strain of New Zealand honey bees. Mite distribution patterns in previous investigations are reviewed and compared, with differences between strains examined to determine whether parasitisation patterns reflect inherent mite resistance in a resistant population. No significant difference was observed between the spatial distribution of mites in the susceptible and resistant bee populations. Consistent with previous investigations, a significant asymmetry in mite location was observed. A total of 63.1% and 62.0% of metasoma mites found on the left side of the bee, and 83.5% and 85.5% found on the third abdominal segment, for Varroa-resistant and Varroa-susceptible bee populations, respectively. The mechanism of resistance strain therefore seems unlikely to be associated with differences in mite parasitisation patterns. Whether this asymmetric distribution is a result of parasite or host behaviour is unclear, however, discovering the underlying reason for this pattern of mite parasitisation may reveal information about the host-parasite relationship that could be exploited to devise novel mite control methods.
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7. Retention and survival of Plasmodium sporozoites in the spleen.
PMID:日期:2026-09-01A central role of the spleen during the Plasmodium erythrocytic infection has been extensively described and acknowledged. However, whether it also influences the sporozoites in their journey toward the liver it is still unclear. In this paper we report that the intravenously inoculated P. yoelii and P. berghei sporozoites are retained in the spleen. In situ observations of parasite expressing GFP revealed the presence of live sporozoites in the splenic parenchyma for at least three hours after their inoculation. This suggests that the spleen might play an additional role beyond one of simply trapping and destroying sporozoites on their journey from the skin to the liver.
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8. Primary infection with Cystoisospora suis modulates systemic immunity and the gut microbiota during secondary infection in piglets.
PMID:日期:2026-09-01Cystoisospora suis is a highly pathogenic porcine coccidian species that causes severe enteric disease in neonatal piglets. This study investigated how primary infection with C. suis modulates the gut microbiota and systemic immunity and shapes the host's response to a secondary challenge. Piglets were assigned to four groups: uninfected control (NC), early infection only (EI; 500 oocysts at 5 days), late infection only (LI; 5000 oocysts at 19 days), and early + late infection (EL; 500 oocysts at 5 days + 5000 oocysts at 19 days). Compared to the LI group, the EL group exhibited a markedly attenuated infection phenotype, demonstrating a 98.79% reduction in fecal oocyst shedding. At 8 days post-challenge, 16S rRNA sequencing and transcriptomic analyses were performed on intestinal segments and peripheral blood mononuclear cells (PBMCs). RNA sequencing revealed significant upregulation of immune-related genes in PBMCs of the LI group, including IFNG, TNF, STAT1, CCL2, CXCL10, GBP1, and GBP2, associated with inflammatory and antimicrobial responses. This response was markedly attenuated in the EL group. 16S rRNA analysis showed higher microbial alpha diversity in the cecum than in the jejunum and ileum. Post-challenge, the LI group displayed reduced ileal and cecal diversity (particularly ileum) and increased Escherichia-Shigella abundance. In contrast, the EL group maintained elevated proportions of taxa such as Lactobacillus and Clostridium_sensu_stricto_1, indicating that primary infection mitigates challenge-induced dysbiosis. Spearman correlation analysis revealed significant microbiota-immune associations. The relative abundance of genera such as Turicibacter and Clostridium_sensu_stricto_1 was negatively correlated with pro-inflammatory genes (e.g., CCL2, CCL4). In contrast, the Escherichia-Shigella was positively correlated with immune effector genes (e.g., GBP1, XCL1), reflecting an active host defense response. These findings demonstrate that primary C. suis infection modulates the host's response to secondary infection by reshaping systemic immunity and the gut microbiota, providing mechanistic insights that could inform future anticoccidial strategies in swine.
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9. Flow cytometry-based evaluation of hepatic infection by non-fluorescent Plasmodium parasites.
PMID:日期:2026-09-01The complex life cycle of Plasmodium parasites, involving both liver and blood stages of infection in the mammalian host, presents significant challenges for malaria research. Although advances have been made in malaria vaccination and treatment strategies, important gaps in our understanding of the asymptomatic liver stage of Plasmodium infection remain. While reporter gene-expressing parasites are commonly used for drug screening and parasite biology studies during this phase of the Plasmodium life cycle, tools for assessing and quantifying hepatic infection in the absence of parasite-encoded reporter genes are limited. Here, we present a novel flow cytometry-based method that enables the quantitative assessment of infection of hepatic cells by non-fluorescent Plasmodium parasites. This method uses two parasite proteins, heat shock protein 70 (HSP70), found in the parasite cytoplasm, and upregulated in infectious sporozoites 4 (UIS4), located on the parasitophorous vacuole membrane, as markers for parasite detection and quantification. We demonstrate that the use of these markers facilitates the rapid and cost-effective quantification of hepatic infection and intracellular development of Plasmodium parasites devoid of fluorescent reporter genes. This method addresses critical regulatory and technical challenges to the evaluation of reporter-free whole-sporozoite vaccine candidates and could serve as a versatile tool for broader malaria research.
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10. Characterization of novel Trypanosoma species from birds and amphibians in the Colombian dry forest using an integrative taxonomic approach.
PMID:日期:2026-09-01Trypanosomatids are flagellated protozoa that infect a wide range of hosts. While Trypanosoma and Leishmania are extensively studied due to their medical importance, information regarding species infecting wildlife remains scarce. This study aimed to characterize trypanosomatids from Colombian amphibians, birds, and mammals using an integrative taxonomic approach. We sampled 46 birds, 18 reptiles and amphibians, and 124 mammals within the tropical dry forest of Tolima, Colombia. Detection was performed employing novel Hsp70 (671 bp) and 18S rRNA (1,400-1,900 bp) primers. Positive PCR products were sequenced using Oxford Nanopore Technologies for phylogenetic inference and species delimitation. Morphometric traits were measured from blood smears, and phenotypic variation was assessed via PCA and PERMANOVA. The combination of molecular markers, species delimitation, and morphometrics led to the discovery of three new species: Trypanosoma vallejoi n. sp. and Trypanosoma carranzai n. sp. in wild birds, and Trypanosoma guhli n. sp. in amphibians. This integrative framework provides a robust and cost-effective tool for trypanosomatid diagnosis in wildlife. These findings reveal a hidden diversity of trypanosomatids in Neotropical ecosystems and demonstrate the value of molecular tools in bridging wildlife surveillance with evolutionary and taxonomic research.