FOLIA MICROBIOLOGICA微生物学学报
FOLIA MICROBIOLOGICA(英文缩写 FOLIA MICROBIOL),ISSN 0015-5632,eISSN 1874-9356,中文译名:微生物学学报 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.629 | Q3 |
| 2022 | 2.600 | Q3 |
| 2023 | 2.400 | Q3 |
| 2024 | 3.100 | Q2 |
| 2025 | 3.100 | Q3 |
FOLIA MICROBIOLOGICA 最新收录文献
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1. Global research trends, thematic evolution, and one health implications of ESBL-producing Escherichia coli: a bibliometric and science mapping analysis, 2001-2025.
1. 产ESBL大肠杆菌的全球研究趋势、主题演变及同一健康意义：2001-2025年文献计量学与科学知识图谱分析PMID:日期:2026-10-02Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli is classified by the World Health Organization (WHO) as a highest-priority pathogen and represents a major threat to modern medicine. This study provides a bibliometric and science-mapping analysis of the global research landscape, intellectual structure, and thematic evolution of ESBL-producing E. coli from 2001 to 2025. A total of 3,483 records retrieved from the Web of Science Core Collection were analyzed using R version 4.6.1 and the Biblioshiny interface 5.0. Performance analysis assessed publication productivity and citation impact. Keyword co-occurrence, thematic mapping, and longitudinal thematic-evolution analyses were used to examine the conceptual structure of the field. The literature showed exponential growth, with an annual growth rate of 28%. Germany, China, and the United States were prominent in the country-level visualizations. Frontiers in Microbiology was the most relevant source. Thematic mapping identified themes related to resistance, prevalence, poultry, and food-producing animals. Thematic evolution showed continuity and changes in emphasis among E. coli, Enterobacteriaceae, antibiotic resistance, and prevalence-related themes. ESBL-producing E. coli research encompasses resistance mechanisms, prevalence, and animal, food, and environmental contexts, with implications for One Health research. ESBL-producing E. coli serves as an indicator organism for examining resistance transmission across the human-animal-environment continuum and for informing One Health strategies. Future research should prioritize integrated molecular surveillance and antimicrobial stewardship interventions across interconnected clinical, animal, food, and environmental reservoirs.
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2. Linsitinib: a tyrosine kinase inhibitor with dual host-parasite targeting potential against leishmaniasis.
2. 林西替尼：一种具有双重宿主-寄生虫靶向潜力的酪氨酸激酶抑制剂，可用于抗利什曼病PMID:日期:2026-10-02Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., that contributes substantially to global morbidity. Considering the toxicity, drug resistance and limited efficacy of current therapies, drug repositioning represents an efficient approach for identifying novel antileishmanial agents from existing pool of drugs. In this context, we evaluated antileishmanial potential of Linsitinib, a known tyrosine kinase inhibitor and an anticancer molecule in advance stages of development. Linsitinib demonstrated potent anti-proliferative activity with IC values of 1.308 ± 0.1267µM against L. donovani and 3.865 ± 0.9688µM against L. mexicana promastigotes with marginal toxicity against human THP-1 macrophages at same doses. Linsitinib exhibited pronounced anti-amastigote activity with IC values of 0.8788µM and 1.014µM, against L. donovani and L. mexicana respectively. Selectivity index (SI) values of 51.77 (L. donovani) and 44.87 (L. mexicana) further corroborated the selective activity of Linsitinib, against Leishmania amastigotes over host cells. To ascertain the mechanistic details of in vitro inhibition, in silico studies were performed against, N-myristoyltransferase (NMT) enzyme, as a key parasite target and human PI3K to establish host-directed immunomodulatory activity. In silico molecular docking and molecular dynamics simulations demonstrated stable binding of Linsitinib with both targets, supported by hydrogen bonding, hydrophobic interactions and favorable stability parameters (RMSD, RMSF, radius of gyration and solvent-accessible surface area). Overall, Linsitinib demonstrates marked inhibition of Leishmania parasites, and this activity is supported through NMT-mediated disruption of parasite viability and PI3K/Akt-driven host immune modulation, supporting its candidacy as a dual-targeting broad-spectrum therapeutic alternative for leishmaniasis.
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3. Correction to: The gut microbiota-miRNA axis in multiple sclerosis: Mechanisms and therapeutic potentials.
3. 更正：多发性硬化症中的肠道微生物群-miRNA轴：机制与治疗潜力PMID:日期:2026-10-01该文献暂无摘要。
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4. Methodological heterogeneity in mushroom extract antimicrobial research (2012-2025): a structured narrative evidence gap analysis and proposed reporting framework.
4. 蘑菇提取物抗菌研究中的方法学异质性（2012-2025）：一项结构化叙述性证据缺口分析及拟议报告框架PMID:日期:2026-09-26Mushroom (Basidiomycete) extracts have been investigated for over two decades as candidate natural antimicrobial agents amid rising concern over antimicrobial resistance, yet the comparability of this evidence base remains unresolved because assay type, solvent system, concentration units, and inoculum standardization vary widely across studies. This structured narrative evidence gap analysis maps post-2012 primary and review literature on mushroom extract antimicrobial activity, assesses whether methodological heterogeneity continues to prevent quantitative pooling, and proposes a tiered reporting framework to guide future standardization. A single-reviewer, AI-assisted search was conducted between 15 January and 30 June 2025 across major databases and Philippine institutional journal platforms, supplemented by two-generation forward and backward citation snowballing from two anchor reviews. This exercise is positioned as a preliminary gap analysis rather than a completed systematic or scoping review; no dual-reviewer screening, licensed database export, or formal risk-of-bias appraisal was performed. Eleven sources met eligibility criteria: three narrative reviews and eight primary in vitro studies. Susceptibility patterns for Gram-positive versus Gram-negative bacteria were inconsistent across the primary studies. Among studies that directly compared solvents, polar organic extracts showed greater antimicrobial activity than aqueous extracts in each of the three studies making a direct within-study comparison, though this pattern rests on a small, species- and method-heterogeneous sample and should not yet be generalised. Outcome units were not interchangeable, and reporting of replicates, inoculum density, and strain identifiers was inconsistent. The standardization gap identified over a decade earlier persists; quantitative meta-analysis is not currently supportable. A two-tier reporting framework is proposed to improve comparability and prepare future primary studies for pooled analysis, pending validation through a broader dual-reviewer systematic review with full database access.
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5. Extracellular silver nanoparticles by Citricoccus alkalitolerans and Brevibacillus brevis using response surface methodology: characterization, antibacterial activity, and biocompatibility assessment on nonwoven fabric for wound dressing applications.
PMID:日期:2026-09-25Textile substrates incorporating antimicrobial agents offer a significant advantage in managing chronic wound infections, a major clinical challenge exacerbated by the rising prevalence of multidrug-resistant pathogens. This study aimed to fabricate silver nanoparticles (AgNPs) with potent antimicrobial activity specifically targeting drug-resistant wound pathogens using a green synthesis approach with locally isolated bacteria. Production was systematically optimized via response surface methodology, and the resulting AgNPs were characterized using UV-Vis spectroscopy, X-ray diffractometry, and transmission electron microscopy, which confirmed nanoparticle formation with average sizes of approximately 10 nm. Optimal biosynthesis was achieved when the producer bacterium was cultured with 1 mM silver nitrate at pH 7 and incubated at 35 °C for 73 h. The biosynthesized AgNPs were subsequently loaded onto nonwoven fabric, a widely used material in wound dressings due to its breathability, absorbency, and conformability and evaluated for antibacterial activity against Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739). The AgNP-coated fabric exhibited promising antibacterial activity against both Gram-positive and Gram-negative pathogens, producing inhibition zones of 29 mm and 27 mm, respectively. These findings demonstrate the potential of bacterially synthesized AgNP-loaded nonwoven fabrics as effective, biocompatible antimicrobial wound dressings for combating multidrug-resistant wound infections in clinical settings.
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6. Ignatzschineria indica bacteremia in a fatal case of accidental wound myiasis.
6. 一例意外伤口蝇蛆病致死病例中的印度伊格纳茨菌血症PMID:日期:2026-09-24Ignatzschineria indica is a rare Gram-negative bacterium increasingly recognized as a potential human pathogen associated with wound myiasis and severe bloodstream infections. Here we report a fatal case of I. indica bacteremia in a 63-year-old woman admitted to the intensive care unit with septic shock. The patient had arterial hypertension and liver cirrhosis and was found after prolonged immobilization in severely neglected conditions. Clinical examination revealed extensive pressure ulcers complicated by maggot infestation and a left pertrochanteric femoral fracture. Blood cultures became positive for Gram-negative rods, with the isolate identified by mass spectrometry as I. indica. Antimicrobial susceptibility tests using gradient diffusion demonstrated susceptibility to all tested antibiotics (cefotaxime, cefepime, meropenem, piperacillin/tazobactam, ciprofloxacin, trimethoprim-sulfamethoxazole and gentamicin). However, despite intensive care management, broad-spectrum antimicrobial therapy, and surgical wound debridement, the patient developed progressive multiorgan failure and died from refractory septic shock. Subsequently, the presence of I. indica in the blood culture was confirmed by whole-genome sequencing, showing a 98.8% average nucleotide identity with the reference genome. This case highlights the pathogenic potential of I. indica in patients with neglected myiasis-associated wounds. The rarity lies particularly in the fact that despite all modern available care (including necrectomy, debridement, and treatment with suitable antibiotics), the patient died within three days of admission. This is unique in Central Europe, where no report on lethal infection with I. indica has been reported so far. Hence, this paper can serve as a valuable piece of knowledge on the treatment of maggot-infested wounds, particularly where I. indica infections are concerned.
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7. Bacteriophages and polymeric delivery systems: a mapping review.
7. 噬菌体与聚合物递送系统：一项映射综述PMID:日期:2026-09-24Bacteriophages are viruses that specifically infect bacteria and have emerged as promising agents for bacterial control in human, animal, and environmental fields. On the other hand, their practical application is limited by instability outside the bacterial hosts, which compromises their efficacy. The incorporation of bacteriophages into polymeric materials has been explored as a strategy to protect the viruses from rapid environmental inactivation and, in some cases, to allow controlled release. In this review, association maps provide a broad overview of the main polymers and fabrication approaches used to improve the stability and functionality of bacteriophages for biotechnological applications. A systematic search was performed to identify studies evaluating polymer-bacteriophage composites focusing on polymer types, bacteriophage species and fabrication processes. The results highlight the broad application of alginate and chitosan, mainly associated with ionic gelation technique, targeting bacterial strains including Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The oral delivery of bacteriophages, wound dressings and food packaging are among the main applications. Data revealed polymer and approaches selection are mainly associated with intended uses of delivery systems and the target bacteria.
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8. Synergistic pre‑treatment-driven dark fermentation of domestic organic waste for high‑yield biohydrogen production.
8. 协同预处理驱动的生活有机废物暗发酵高效产氢PMID:日期:2026-09-24The biological conversion of into bioenergy offers a dual advantage of sustainable energy generation and effective waste management. Until now, the efficiency of dark fermentation processes has depended critically on optimized pre‑treatment strategies that unlock fermentable substrates from complex biowaste feedstocks. This study aims to evaluate and optimize multiple pre‑treatment approaches to enhance the simultaneous production of biohydrogen and bioethanol from biowaste. Among the tested methods, the integrated acid-enzymatic hydrolysis pathway released the highest reducing sugar content, increasing it by 39% by effectively depolymerizing lignocellulosic and polysaccharide‑rich fractions. The resulting hydrolysate produced the maximum biohydrogen and minimum bioethanol yields, reaching 97 mL/g and 5.12 mg/g, respectively, under dark fermentation conditions. Comparative assessments showed that ViL enzymatic hydrolysis and acid hydrolysis alone yielded lower biohydrogen yields of 88 mL/g and 75 mL/g, respectively. Overall, the findings highlight that integrating strategic pre-treatment with dark fermentation can serve as an efficient and sustainable route for biohydrogen production from biowaste.
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9. Phylogenetic characterization and optimization of waste-valorizing Priestia megaterium GASCKPHA2 for sustainable polyhydroxyalkanoate production.
PMID:日期:2026-09-24Polyhydroxyalkanoate (PHA) is a microbial polyester naturally produced by many microbes as a starvation reservoir. However, their large-scale production is limited due to their high production cost. This study focused on the issue mentioned above by using readily available renewable materials as carbon sources for PHA production. The main aim of this study was to screen and identify a potential bacterium obtained from renewable organic materials for PHA production. The isolates were tested for their PHA-producing ability by primary and secondary screening methods, and the most efficient isolate was identified as Priestia megaterium GASCKPHA2 through phylogenetic studies. The culture conditions were optimized using one- factor-at-a time to increase PHA production using renewable, low-cost carbon substrates. The difference among the results were statistically analyzed. Among all substrates, banana peel extract was found to support high PHA production. The polymer was extracted and analyzed using SEM, FTIR and proton NMR. The characterization studies provide supporting evidence that the extracted polymer was Polyhydroxybutyrate (PHB) like PHA. The extracted polymer was fabricated into a flexible film, to demonstrate its film forming ability. Further studies are required to evaluate its material properties to evaluate its suitability for biodegradable packaging applications. This study also highlights the application of microbial biotechnology for agro-waste valorization by P. megaterium for sustainable polymer production within a circular bioeconomy framework.
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10. Synthesis and biological evaluation of tris(4-methoxyphenyl)phosphonium-hydrazone derivatives against clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates: antibacterial, antibiofilm, and gene expression analyses.
PMID:日期:2026-09-21In this study, four novel tris(4-methoxyphenyl)phosphonium-hydrazone derivatives were synthesized and structurally characterized by FT-IR and NMR spectroscopy. Their antioxidant activities were evaluated using DPPH and ABTS radical scavenging assays. The antibacterial and antibiofilm activities of the synthesized compounds were investigated against eight clinical MRSA isolates. Furthermore, the effects of the most active compound on the expression of the icaA, dltB, and mepA genes were determined by quantitative real-time PCR (qRT-PCR). Among the synthesized compounds, compound 1d exhibited the strongest antioxidant activity, with IC₅₀ values of 37.1 ± 0.62 and 23.1 ± 0.70 µg/mL against DPPH and ABTS radicals, respectively. In the disk diffusion assay, all synthesized compounds produced larger inhibition zones than the cefoxitin (FOX, 30 µg) control. Compound 1c demonstrated superior antibacterial activity with MIC values ranging from 0.5 to 1 µg/mL against the tested clinical MRSA isolates. At the MIC level, compound 1c maintained considerable antibiofilm activity, reducing biofilm formation by 30.2-48.4%. Moreover, compound 1c significantly downregulated the expression of the biofilm- and resistance-associated genes icaA, dltB, and mepA. These findings indicate that tris(4-methoxyphenyl)phosphonium-hydrazone derivatives, particularly compound 1c, are promising candidates for the development of new therapeutic agents against biofilm-associated MRSA infections.