FEBS LETTERSFEBS 通讯
FEBS LETTERS(英文缩写 FEBS LETT),ISSN 0014-5793,eISSN 1873-3468,中文译名:FEBS 通讯 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.864 | Q2 |
| 2022 | 3.500 | Q2 |
| 2023 | 3.000 | Q2 |
| 2024 | 3.000 | Q2 |
| 2025 | 3.100 | Q2 |
FEBS LETTERS 最新收录文献
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1. Reactive oxygen species-induced lipid peroxidation mediates Wnt-dependent lipodystrophy and associated skin fibrosis.
1. 活性氧诱导的脂质过氧化介导Wnt依赖性脂肪萎缩及其相关皮肤纤维化PMID:日期:2026-10-05Skin fibrosis is marked by extracellular matrix accumulation and dermal white adipose tissue (DWAT), resulting in tissue stiffening. We show that sustained Wnt activation in mature dermal adipocytes induces lipodystrophy and promotes fibrotic remodeling via oxidative stress. Meta-analysis of early systemic sclerosis skin transcriptomes reveals increased reactive oxygen species (ROS) production and lipid peroxidation. In cultured mouse dermal adipocytes, Wnt activation triggers a robust increase in ROS and lipid peroxidation, which is suppressed by scavengers. In vivo, Wnt activation elevates oxidative stress in DWAT, and N-acetyl-L-cysteine scavenger protects from DWAT lipodystrophy and dermal collagen accumulation. These findings identify a Wnt-ROS-lipid peroxidation axis as a key driver of lipodystrophy and skin fibrosis, highlighting a potential therapeutic target.
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2. From timekeeping to divisions-Molecular links between circadian rhythms and cell cycle.
2. 从生物钟到细胞分裂——昼夜节律与细胞周期之间的分子联系PMID:日期:2026-09-26Circadian rhythms and the cell cycle are two fundamental biological oscillators. They are linked through molecular mechanisms creating coupled oscillators where the outcomes of this coupling depend on numerous factors, such as the directionality of coupling (i.e., unidirectional vs. bidirectional), periods of the two oscillators, and the number and strength of connections. In this review, we provide a general overview of the links between circadian rhythms and the cell cycle and discuss potential implications of this connection in stem cell proliferation and differentiation of mammalian cells.
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3. The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure-function relationships and relevance to human pathology.
PMID:日期:2026-09-25SLC transporters are the entry gates of nutrients required by intracellular enzymes to accomplish cell metabolism. SLCs include many amino acid transporters, which belong to different families and are characterized by redundancy, cross-specificity, and diverse transport mechanisms. Amino acid transporters are critical, as demonstrated by the onset of diseases caused by their altered expression, function, or localization. Despite their crucial roles, a systematic description of structure/function relationships of amino acid transporters is still far from being obtained. Among many SLCs specific toward amino acids, the heterodimeric transporters (HATs) of the SLC7 family, paired to proteins of the SLC3 family via a conserved disulfide, have emerged. Members A5 (LAT1), A6 (yLAT2), A7 (yLAT1), A8 (LAT2), A10 (ASC1), and A11 (xCT) are combined with SLC3A2; the members A9 (bAT1) and A13 (AGT1) are combined with SLC3A1. Even though the members of the SLC3 family are classified as solute carriers (SLCs), they do not display transport capacity but are mainly involved in assisting the trafficking of the transport SLC7 subunits. An update of the structure/function relationships and relation to pathologies is reported.
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4. Smaller is better: nanobodies meet NMR.
4. 越小越好：纳米抗体与核磁共振的邂逅PMID:日期:2026-09-25Nanobodies, the single-domain antigen-binding fragments derived from camelid heavy chain antibodies, have emerged as powerful tools in structural biology. Their small size, high stability, and ability to bind with exceptional specificity make them ideal for applications in nuclear magnetic resonance (NMR) spectroscopy. In protein NMR, nanobodies can serve as chaperones to stabilize flexible regions, reduce conformational heterogeneity, and enhance spectral quality. They facilitate the study of challenging targets such as membrane proteins, large complexes, and intrinsically disordered proteins by improving solubility and enabling selective labeling strategies. Furthermore, nanobody-assisted NMR spectroscopy provides unique opportunities for probing dynamic interactions and conformational states under near-physiological conditions. This review summarizes recent advances in nanobody engineering for NMR studies, including the synthetic nanobodies, highlights the nanobodies' role in overcoming size and stability limitations, and discusses future directions for integrating nanobodies into emerging NMR methodologies, with an emphasis on protein dynamics and protein-protein interactions in the context of drug discovery.
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5. Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research.
5. 膜组成与热力学身份作为合成细胞研究的生命边界PMID:日期:2026-09-25Biological membranes are more than structural boundaries: they are the thermodynamic interfaces that enable living systems to maintain a state far from equilibrium, continuously exchanging matter and energy with their environment. In this review, we explore three interconnected themes. First, we examine the biochemical composition of cell membranes, with particular focus on Escherichia coli, including lipid diversity, membrane asymmetry, and homeoviscous adaptation. Second, we reframe the membrane as the physical representation of the Markov blanket, the statistical boundary separating internal from external states, and discuss how biological systems minimize free energy to maintain homeostasis. Third, we evaluate synthetic cell research strategies for reconstructing life-like systems, highlighting how out-of-equilibrium approaches, based on selective membrane transport coupled to metabolic networks, may recapitulate the thermodynamic identity of living cells.
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6. Characterizing two nanobodies for SMAD4.
PMID:日期:2026-09-24In metazoans, TGF-β signaling regulates essential cellular processes via the SMAD proteins. Many biophysical and cellular assays of SMAD-driven signaling require molecular tools that can recognize them in their native folded state. In this context, we report two nanobodies (Nbs), NbS4A1 and NbS4A7, which target the 3D structure of the human SMAD4-MH2 domain with high affinity and specificity. X-ray structures of the Nb-SMAD4 complexes reveal that each nanobody recognizes the SMAD4-MH2 domain through distinct but overlapping sites, precluding their simultaneous binding. Furthermore, NbS4A1 impedes SMAD4 binding with R-SMADs while NbS4A7 recognizes SMAD4 even when bound to R-SMADs. These distinct interaction modes will enable the study of folded SMAD complexes with cofactors and/or DNA in different experimental contexts.
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7. {"_":"Structural and biochemical analysis of a B superbinder.","sub":["12"]}
PMID:日期:2026-09-23A prominent bacterial family in the human gut is Bacteroidetes, for which cobalamin (vitamin B) is an essential micronutrient. Here, we characterized the structural-function relationships underlying the role of three BtuG family proteins, BtuG1, BtuG2, and BtuG3, in cobalamin acquisition. We solved crystal structures (resolution between 2 and 1.5 Å) of these homologs bound to different cobalamin forms and the precursor cobinamide, and measured the binding affinities by grating coupled interferometry. We observed high binding affinities, with K values in the low picomolar range, underlining their role in cobalamin scavenging. Mutations based on the structures resulted in altered binding affinities for cobalamin and its precursor. This study provides structural and quantitative insights into the B scavenging mechanism of BtuG proteins.
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8. BRCA1-mediated transcriptional repression of FABP3 - Implications for breast cancer progression and chemosensitivity.
8. BRCA1介导的FABP3转录抑制——对乳腺癌进展和化疗敏感性的影响PMID:日期:2026-09-22Transcriptional regulation of key target genes by BRCA1 is crucial for its diverse functions. Here, we report fatty acid-binding protein 3 (FABP3) as a novel BRCA1-repressible target gene. Functional BRCA1 represses FABP3 promoter activity while mutant BRCA1 breast cancer cell lines show higher endogenous FABP3 expression which was reduced upon introducing wild-type protein. Furthermore, using deletion constructs we identified a critical minimal responsive FABP3 promoter region and confirmed BRCA1 recruitment to this site by ChIP. FABP3 overexpression promoted proliferation, clonogenicity, and migration in breast cancer cells while conferring sensitivity to chemotherapeutic drugs. TCGA analysis correlated high FABP3/BRCA1 expression with reduced overall survival. These findings implicate FABP3 de-repression as a mechanism linking BRCA1 loss to tumor aggressiveness and chemosensitivity.
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9. Invisible but not inaccessible-Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods.
PMID:日期:2026-09-22Intrinsically disordered proteins (IDPs) are often readily characterized as soluble monomers, whereas their biological and pathological roles frequently involve transient, heterogeneous, or sparsely populated oligomers. Such assemblies are often described as 'invisible' but invisibility is method-dependent: Oligomers that escape direct detection by one technique may remain accessible through indirect or complementary measurements. Solution NMR is uniquely positioned to exploit exchange between observable monomers and NMR-invisible oligomers, providing residue-specific information on populations, kinetics, and intermolecular contacts. Other methods report on mass, stoichiometry, dimensions, morphology, or site-specific distance distributions. Here, we discuss how integrating orthogonal measurements can overcome method-specific blind spots and yield a self-consistent model that simultaneously accounts for structure, populations, exchange kinetics, and morphology, something no single method can provide.
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10. A context-dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma.
10. eIF6在黑色素瘤获得性维莫非尼耐药中的情境依赖性调节作用PMID:日期:2026-09-22Acquired resistance to vemurafenib, a BRAF-targeted therapy, remains a major challenge in melanoma. The translation initiation factor eIF6 has been implicated in cancer; however, its role in vemurafenib resistance is poorly understood. We investigated eIF6 using melanoma cell lines with distinct mutational backgrounds. RNA sequencing of a resistant cell line revealed dysregulation of MAPK, PI3K-AKT, metabolic, and ribosome biogenesis pathways together with increased eIF6 expression and alterations in translation-related signaling. Silencing of eIF6 led to reduced proliferation and partially restored vemurafenib sensitivity, while its overexpression increased sensitivity irrespective of BRAF status via mTOR and MAPK modulation. These findings reveal a context-dependent role for eIF6, linking translation regulation to therapeutic response in melanoma.