FERTILITY AND STERILITY生育与不孕
FERTILITY AND STERILITY(英文缩写 FERTIL STERIL),ISSN 0015-0282,eISSN 1556-5653,中文译名:生育与不孕 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 7.490 | Q1 |
| 2022 | 6.700 | Q1 |
| 2023 | 6.600 | Q1 |
| 2024 | 7.000 | Q1 |
| 2025 | 8.100 | Q1 |
FERTILITY AND STERILITY 最新收录文献
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1. Current Understanding of Genetic Architecture of Polyendocrine Metabolic Ovarian Syndrome (PMOS) - 2026 Update.
PMID:日期:2026-10-02Polyendocrine Metabolic Ovarian Syndrome (PMOS; formerly known as Polycystic Ovary Syndrome, PCOS) is a common, heterogeneous endocrinopathy of reproductive-age women with a frequency of 5-26% worldwide. PMOS is characterized by hyperandrogenemia, ovulatory dysfunction, and polycystic ovarian morphology. A systematic search of the NHGRI-EBI GWAS Catalog and the literature in PubMed identified 17 PMOS GWAS or GWAS Meta-analyses with loci with significant evidence for association with PMOS. The PMOS GWAS identified 120 genomic regions significantly associated with PMOS. Thirty-eight of the PMOS GWAS loci are detected in at least two cohorts, and the majority of replicated regions were observed in multiple ancestries. The genes encoded by PMOS GWAS loci are implicated in gonadotropin secretion and action, folliculogenesis, sex hormone function, age at menopause, adiposity, insulin signaling, T2DM, calcium signaling, endocytosis, lipid and cholesterol levels, and cardiometabolic disease.
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2. Office Hysteroscopic Removal of an IUD-Myoma Composite Using an 18.5 Fr Hysteroscope and Blue Laser in a Postmenopausal Woman with Cervical Atrophy: A No-Anesthesia Approach.
PMID:日期:2026-10-01To study the feasibility and safety of office-based, no-anesthesia, no-dilation hysteroscopic removal of an intrauterine device (IUD)-myoma complex using a blue laser in a postmenopausal woman with severe cervical atrophy. Step-by-step video demonstration of the surgical procedure with narrated explanation. A 56-year-old postmenopausal woman (G2P2, menopause for 7 years) with a 30+ year indwelling T-shaped copper IUD. She had no postmenopausal bleeding or pelvic pain. Examination revealed severe cervical atrophy with marked stenosis. Transvaginal ultrasound (both 2D and 3D) showed the IUD encased by a myoma-like lesion, forming an IUD-myoma complex measuring approximately 2.5 cm × 2.0 cm × 1.8 cm. The patient declined inpatient surgery under anesthesia. Office vaginoscopic hysteroscopy was performed without anesthesia or cervical dilation using an 18.5 Fr continuous-flow hysteroscope (5 Fr working channel). Normal saline was used as the distension medium at a pressure of 100 mmHg with continuous fluid circulation. A 450 nm blue laser (30 W, continuous mode) was introduced through the working channel to vaporize the myoma-like tissue in a stepwise manner. Once the IUD was fully exposed, 5 Fr grasping forceps were used to remove the IUD together with the remaining myoma tissue en bloc. After vaporization, residual tissue fragments were retrieved for histopathological examination. Successful IUD removal, operative time, pain score (Visual Analog Scale, VAS 0-10), intraoperative and postoperative complications, and follow-up ultrasound findings at one week. The procedure was successfully completed without conversion to general anesthesia or cervical dilation. Total operative time was 36 minutes. The patient tolerated the procedure well, reporting mild discomfort (VAS pain score 3/10). No intraoperative complications occurred. The patient experienced slight vaginal bleeding for 2 days postoperatively, which resolved spontaneously. At the one-week follow-up visit, transvaginal ultrasound revealed a normal uterine cavity with no residual IUD fragments or myoma tissue. Histopathological examination of the residual tissue fragments confirmed benign leiomyoma. Office-based, no-anesthesia, no-dilation hysteroscopic removal of an IUD-myoma complex using a blue laser is feasible and safe in a postmenopausal woman with severe cervical atrophy. This technique offers a patient-centered alternative for women at high anesthesia risk or who prefer to avoid hospital admission. To our knowledge, this is the first report of using a blue laser for an IUD-myoma complex under such challenging conditions. The patient included in this video gave consent for publication of the video and posting of the video online including social media, the journal website, scientific literature websites (such as PubMed, ScienceDirect, Scopus, etc.) and other applicable sites.
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3. Posthumous reproduction: an Ethics Committee opinion.
PMID:日期:2026-09-29This Ethics Committee report outlines the ethical issues around the posthumous use of gametic tissue or embryos. This document replaces the last version of this document, published in 2018, titled "Posthumous retrieval and use of gametes or embryos: an Ethics Committee opinion" (Fertil Steril. 2018;110:45-9).
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6. Coding guidance for laboratory procedures during assisted reproductive technology cycles.
PMID:日期:2026-09-24This document provides updated coding information for services related to assisted reproductive technology procedures. This document replaces the 2016 American Society for Reproductive Medicine document of the same name. (Fertil Steril 2016;81:1168-71).
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8. FMR1-Associated Diminished Ovarian Reserve: Reduced Oocyte Yield Without Loss of Per-Embryo Ploidy.
PMID:日期:2026-09-22To determine whether diminished ovarian reserve in FMR1 premutation carriers reflects a purely quantitative deficit or is also associated with impaired per-embryo chromosomal competence, including embryo aneuploidy risk. Identification of FMR1 premutation patients from a clinic database. Subsequent retrospective cohort study with two analytic frameworks: (1) a carrier PGT subcohort analysis characterizing ovarian-reserve markers and per-embryo ploidy across PGT modalities; (2) a 1:1 matched-cohort analysis of FMR1 premutation-carrier PGT-A cycles (n=33) versus non-carrier PGT-A controls (n=33) matched on age, BMI and oocyte yield. Single private academically affiliated IVF center, January 2014-December 2023. 173 fresh IVF/ICSI cycles from FMR1 premutation carriers formed the carrier cohort; 142 underwent PGT (PGT-A and/or PGT-M) and formed the PGT subcohort. For the matched-cohort analysis, 33 carrier PGT-A cycles were matched 1:1 to 33 controls drawn from 5,376 non-carrier PGT-A cycles. FMR1 premutation carrier status. Quantitative metrics: AMH, oocyte yield, mature oocytes, normal fertilizations, and usable blastocysts. The primary embryo-competence outcome was euploidy per embryo biopsied (Poisson incidence-rate ratio with log-offset for embryos biopsied) in PGT-A-only cycles; secondary outcomes were the proportion of cycles with ≥1 euploid embryo and the all-aneuploid proportion. Quantitative ovarian-reserve markers (AMH, oocyte yield, mature oocytes, fertilisations, usable blastocysts) were lower in carriers, with a graded descriptive relationship to CGG repeat length (most evident for AMH and oocyte/mature-oocyte yield) in the subset with available CGG data. Of 173 carrier cycles, 142 underwent PGT, with at least one blastocyst biopsied in 124. In the carrier PGT subcohort, the odds of obtaining ≥1 euploid embryo were lower with advancing maternal age and in co-tested PGT-A+M versus PGT-A cycles, with no independent association for AMH or BMI; the usable-blastocyst rate per oocyte was not associated with PGT modality, age or BMI (AMH trend p=0.07). In the matched cohort, 84.8% of carriers versus 75.8% of controls achieved ≥1 euploid embryo; the three-category biopsy-outcome distribution did not differ between groups (p=0.67). Poisson regression confirmed no significant difference in per-embryo euploidy rate between groups (rate ratio 1.01, 95% CI 0.82-1.25, p=0.91). An IPTW sensitivity analysis was concordant with the matching results (IRR 0.996, 95% CI 0.83-1.19). FMR1 premutation carriers exhibit quantitative reductions in ovarian reserve and early embryology outcomes, but do not demonstrate impaired embryo ploidy once blastocysts reach biopsy stage. Although premutation carriers may yield fewer eggs, their per-embryo euploidy risk remains comparable to age-, BMI- and yield-matched non-carriers. These findings are restricted to clinically ascertained, PGT-A-eligible premutation carriers and to per-embryo ploidy among biopsied blastocysts, and should not be generalised to unscreened carriers, diminished ovarian reserve of other aetiologies, or non-chromosomal aspects of embryo competence.
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9. Expanding Horizons in Fertility Preservation: Diverse Populations, Emerging Indications, and Ethical Considerations.
PMID:日期:2026-09-21Fertility preservation has traditionally centered on intervention before gonadotoxic cancer treatment, yet many patients do not fit this conventional pathway. Reproductive risk may arise before puberty, result from a genetic predisposition to primary ovarian insufficiency, intersect with gender-affirming care, or be recognized only after gonadotoxic exposure. This Views and Reviews series examines fertility preservation in transgender and gender-diverse patients, girls before and during puberty, patients with genetic conditions associated with primary ovarian insufficiency, and individuals seeking preservation after chemotherapy or radiation. Across these settings, evidence is frequently limited, the optimal timing of intervention may be uncertain, and technical feasibility does not necessarily predict future reproductive benefit. The series considers clinical strategies and outcomes alongside access, procedural burden, autonomy, psychosocial effects, and long-term safety, providing a framework for individualized counseling as fertility-preservation indications continue to evolve.
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10. Precision Surgery for Colorectal Deep Endometriosis: Strategies for Complete Excision Without Segmental Resection.
PMID:日期:2026-09-21To study the role of robotic surgery integrated with intraoperative ultrasound in achieving complete excision of colorectal deep endometriosis while avoiding segmental bowel resection. Educational surgical video demonstrating a stepwise robotic approach with integrated intraoperative ultrasound for lesion localization, excision, and real-time intraoperative decision-making. A 38-year-old G0 patient with recurrent colorectal deep endometriosis presented with chronic pelvic pain, dysmenorrhea, dyschezia, and infertility after a previous rectal shaving procedure. Preoperative transvaginal ultrasound demonstrated a hypoechoic posterior cul-de-sac nodule, and magnetic resonance imaging revealed rectosigmoid deep endometriosis with submucosal invasion (mushroom-cap sign). Robotic excision of colorectal endometriosis guided by intraoperative ultrasound. Two bowel lesions were identified: a proximal sigmoid lesion (15 × 5 mm) and a distal rectal lesion (24 × 9 mm). The sigmoid lesion was excised using a linear stapler, whereas the rectal lesion underwent discoid excision with a circular stapler. Intraoperative ultrasound was used before and after excision to assess lesion extent and confirm completeness of resection. Complete excision of colorectal endometriosis confirmed by intraoperative ultrasound and histopathology, successful preservation of bowel continuity without segmental resection, and optimization of intraoperative surgical decision-making. Post-excision ultrasound confirmed complete removal of the sigmoid lesion. Residual disease was identified at the rectal excision margin, prompting a second discoid excision. Repeat intraoperative ultrasound demonstrated complete removal of the residual lesion. Histopathologic examination confirmed endometriosis in both specimens. Complete excision was achieved without the need for segmental bowel resection. Robotic surgery combined with intraoperative ultrasound enables precise localization, tailored stapler selection, and real-time assessment of colorectal deep endometriosis, facilitating complete excision while preserving bowel integrity. Intraoperative ultrasound verification can detect residual disease requiring immediate re-excision, potentially reducing recurrence and avoiding unnecessary segmental bowel resection. Careful preoperative planning, meticulous robotic dissection, and integration of intraoperative ultrasound optimize surgical outcomes in selected patients with colorectal deep endometriosis.