用于多功能心脏补片及梗死后心肌修复的金属-酚类导电聚合物水凝胶
Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair.
摘要(中文译文)
心肌梗死（MI）会导致不可逆的心肌细胞丢失和不良心室重构，然而目前的心脏补片仍受限于生物活性不足以及与宿主心肌电整合不良。我们报道了一种用于梗死后心肌修复的多功能金属-酚类导电聚合物水凝胶（CPH）。通过一锅法工艺将导电聚吡咯网络与动态Cu-单宁酸（TA）配位整合，从而在单一水凝胶中集成了导电性、机械支撑和氧化还原相关功能。Cu-TA CPH表现出与心肌匹配的力学性能（约19 kPa）、适宜的导电性、良好的生物相容性以及固有的抗氧化和抗菌活性。这些综合特性使该水凝胶补片能够提供机械支撑、促进电通讯并改善MI后的局部微环境。术后第7天，Cu-TA CPH治疗的MI组左心室射血分数高于未接受材料治疗的MI组。这一治疗效果与Bcl-2/Bax比值升高、VEGFR-1表达增强、梗死面积减小以及心肌组织保存改善相关。总体而言，Cu-TA CPH是一种有前景的用于梗死后心肌修复的水凝胶补片。
Abstract
Myocardial infarction (MI) causes irreversible cardiomyocyte loss and adverse ventricular remodeling, yet current cardiac patches remain limited by inadequate bioactivity and poor electrical integration with host myocardium. We report a multifunctional metal-phenolic conducting polymer hydrogel (CPH) for post-infarction myocardial repair. A one-pot process integrates a conductive polypyrrole network with dynamic Cu-tannic acid (TA) coordination, thereby combining electrical conductivity, mechanical support, and redox-related functionality within a single hydrogel. Cu-TA CPH exhibited myocardium-matched mechanical properties (∼19 kPa), suitable conductivity, good biocompatibility, and intrinsic antioxidant and antibacterial activities. These combined features enabled the hydrogel patch to provide mechanical support, facilitate electrical communication, and improve the local microenvironment after MI. On postoperative day 7, left ventricular ejection fraction in the Cu-TA CPH-treated MI group was higher than that in the MI group receiving no material treatment. This therapeutic effect was associated with an increased Bcl-2/Bax ratio, enhanced VEGFR-1 expression, reduced infarct size, and improved myocardial tissue preservation. Collectively, Cu-TA CPH represents a promising hydrogel patch for post-infarction myocardial repair.
如何引用
AMA
Lanbo Shen, Jiahao Yu, Tingting Kong, Xin Huang, Bin Li, William W Yu. Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair.. Biomaterials advances. 2027; doi:10.1016/j.bioadv.2026.215187.
APA
Lanbo Shen, Jiahao Yu, Tingting Kong, Xin Huang, Bin Li, William W Yu (2027). Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair.. Biomaterials advances. https://doi.org/10.1016/j.bioadv.2026.215187
GB/T 7714
Lanbo Shen, Jiahao Yu, Tingting Kong, Xin Huang, Bin Li, William W Yu. Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair.[J]. Biomaterials advances, 2027 doi:10.1016/j.bioadv.2026.215187.
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