利用气体信号分子进行骨科感染治疗：机制与先进递送平台
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
摘要(中文译文)
骨科感染在老龄化人群中日益普遍，带来了沉重的临床和经济负担。尽管抗菌治疗取得了进展，但抗生素耐药性和超级细菌出现等挑战依然存在。气体疗法已成为治疗骨科感染的一种有前景的策略。经典气体信号分子——包括一氧化氮（NO）、一氧化碳（CO）和硫化氢（H₂S）——在受控浓度下表现出抗菌和免疫调节作用，但不当给药可能引发不良反应。本综述批判性地审视了气体信号分子在对抗感染的同时促进骨科再生的双重机制。我们还综述了先进的递送平台——如智能支架、纳米储库和按需释放系统——这些平台被设计用于将气体信号分子靶向递送至感染骨组织。最后，我们讨论了当前的局限性和未来前景，旨在启发用于靶向治疗递送的新型生物材料设计，并推动气体疗法成为骨科感染治疗的可行选择。
Abstract
Orthopaedic infections are increasingly prevalent in the aging population, posing a significant clinical and economic burden. Despite progress in antimicrobial therapies, challenges such as antibiotic resistance and superbug emergence persist. Gas therapy has emerged as a promising strategy for managing orthopaedic infections. Classical gasotransmitters-including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (HS)-exhibit antibacterial and immunomodulatory effects at controlled concentrations, though improper dosing may induce adverse effects. This review critically examines the dual mechanisms through which gasotransmitters combat infection while promoting orthopaedic regeneration. We also survey advanced delivery platforms-such as smart scaffolds, nano-reservoirs, and on-demand release systems-engineered for targeted gasotransmitter delivery to infected bone tissue. Finally, we discuss current limitations and future prospects, aiming to inspire novel biomaterial designs for targeted therapeutic delivery and to advance gas therapy as a viable option for orthopaedic infection treatment.
如何引用
AMA
Jun-Yi Zhang, Yi-Qi Yang, Zhi-Xiong Zhang, Jia-Le Jin, Zhi-Yuan Luo, Dong-Yu Wang, et al. Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.. Bioactive materials. 2027; doi:10.1016/j.bioactmat.2026.05.047.
APA
Jun-Yi Zhang, Yi-Qi Yang, Zhi-Xiong Zhang, Jia-Le Jin, Zhi-Yuan Luo, Dong-Yu Wang, et al (2027). Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.. Bioactive materials. https://doi.org/10.1016/j.bioactmat.2026.05.047
GB/T 7714
Jun-Yi Zhang, Yi-Qi Yang, Zhi-Xiong Zhang, Jia-Le Jin, Zhi-Yuan Luo, Dong-Yu Wang, et al. Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.[J]. Bioactive materials, 2027 doi:10.1016/j.bioactmat.2026.05.047.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出