Correlation of red cell distribution width-to-albumin ratio combined with SOFA score with 28-day all-cause mortality in patients with acute pancreatitis: A retrospective study based on the MIMIC-IV database.
本研究旨在评估红细胞分布宽度与白蛋白比值（RAR）联合序贯器官衰竭评估（SOFA）评分对急性胰腺炎（AP）患者28天全因死亡率的预测效果。在本研究中，我们基于MIMIC-IV（v3.1）数据库对702例AP患者的临床数据进行了回顾性分析。我们采用单因素和多因素Cox回归分析评估了RAR改良SOFA评分与28天全因死亡率之间的关系。此外，通过约登指数确定最佳截断值，并通过受试者工作特征（ROC）曲线和Kaplan-Meier（K-M）生存分析评估联合指标的预测性能。最后，我们通过亚组分析检验了研究结果在不同人群中的稳健性。本研究共纳入702例入住重症监护病房（ICU）的AP患者，并对其28天全因死亡率进行了分析。单因素和多因素Cox回归分析均表明，RAR改良SOFA评分是ICU中AP患者28天全因死亡率的独立危险因素。ROC曲线分析显示，RAR改良SOFA评分与其他评分系统（包括单独使用RAR和SOFA）相比具有更优的预测能力。此外，K-M生存曲线分析显示，高值组（RAR改良SOFA评分≥12.69）的死亡率显著高于低值组（RAR改良SOFA评分<12.69）。RAR改良SOFA评分显著提高了对AP患者28天全因死亡率的预测准确性。
The objective of this study is to evaluate the effectiveness of the red cell distribution width-to-albumin ratio (RAR) in conjunction with the Sequential Organ Failure Assessment (SOFA) score for predicting 28-day all-cause mortality in patients with acute pancreatitis (AP). In this study, we conducted a retrospective analysis of clinical data from 702 patients with AP sourced from the MIMIC-IV (v3.1) database. We evaluated the relationship between the RAR-modified SOFA score and 28-day all-cause mortality using both univariate and multivariate Cox regression analyses. Furthermore, the optimal cutoff value was determined using the Youden index, and the predictive performance of the combined indicator was evaluated through Receiver Operating Characteristic (ROC) curves and Kaplan-Meier (K-M) survival analysis. Finally, we examined the robustness of our findings across different populations through subgroup analyses. A total of 702 patients with AP admitted to the Intensive Care Unit (ICU) were included in this study, and their 28-day all-cause mortality was analyzed. Both univariate and multivariate Cox regression analyses indicated that the RAR-modified SOFA score served as an independent risk factor for 28-day all-cause mortality in ICU patients with AP. ROC curve analysis demonstrated that the RAR-modified SOFA score exhibited superior predictive ability compared to other scoring systems, including RAR and SOFA alone. Additionally, K-M survival curve analysis revealed that the mortality rate was significantly higher in the high-value group (RAR-modified SOFA score ≥ 12.69) compared to the low-value group (RAR-modified SOFA score < 12.69). The RAR-modified SOFA score significantly enhances the predictive accuracy for 28-day all-cause mortality in patients with AP.
Jianlei Chen, Hua Li, Hongfei Wang, Zhiqiang He, Jingzhao Yin, Songsong Yu, et al. Correlation of red cell distribution width-to-albumin ratio combined with SOFA score with 28-day all-cause mortality in patients with acute pancreatitis: A retrospective study based on the MIMIC-IV database.. PloS one. 2026; doi:10.1371/journal.pone.0357579.
Jianlei Chen, Hua Li, Hongfei Wang, Zhiqiang He, Jingzhao Yin, Songsong Yu, et al (2026). Correlation of red cell distribution width-to-albumin ratio combined with SOFA score with 28-day all-cause mortality in patients with acute pancreatitis: A retrospective study based on the MIMIC-IV database.. PloS one. https://doi.org/10.1371/journal.pone.0357579
Jianlei Chen, Hua Li, Hongfei Wang, Zhiqiang He, Jingzhao Yin, Songsong Yu, et al. Correlation of red cell distribution width-to-albumin ratio combined with SOFA score with 28-day all-cause mortality in patients with acute pancreatitis: A retrospective study based on the MIMIC-IV database.[J]. PloS one, 2026 doi:10.1371/journal.pone.0357579.
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