血小板在肿瘤侵袭和转移中的分子机制：一个有争议的作用
The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.
摘要(中文译文)
血小板传统上被认为在止血中发挥作用，如今人们认识到其还积极参与肿瘤进展、血管生成和转移。通过与癌细胞的动态双向相互作用，血小板在计数、平均血小板体积以及分子货物（包括蛋白质和mRNA）方面发生可测量的改变，支持其作为液体活检生物标志物用于早期癌症检测的潜在用途。在肿瘤微环境中，血小板有助于免疫逃逸，支持肿瘤细胞的内渗和外渗，增强循环肿瘤细胞的存活，并促进新生血管形成。此外，它们还能物理性地屏蔽恶性细胞免受免疫监视，从而增加转移潜能。尽管已有背景特异性的抗肿瘤效应报道，但主要证据支持血小板在很大程度上具有促肿瘤和促转移作用。因此，阐明血小板-肿瘤相互作用的分子机制对于改善癌症风险分层、预后评估和治疗开发至关重要。本综述总结了血小板衍生生物标志物的当前进展，并讨论了靶向血小板介导通路以抑制转移和改善癌症患者临床结局的新兴治疗策略。
Abstract
Platelets, traditionally recognized for their role in hemostasis, are now understood to actively contribute to tumor progression, angiogenesis, and metastasis. Through dynamic bidirectional interactions with cancer cells, platelets undergo measurable alterations in count, mean platelet volume, and molecular cargo, including proteins and mRNAs, supporting their potential utility as liquid biopsy biomarkers for early cancer detection. Within the tumor microenvironment, platelets contribute to immune evasion, support tumor cell intravasation and extravasation, enhance the survival of circulating tumor cells, and promote neovascularization. In addition, they can physically shield malignant cells from immune surveillance, thereby increasing metastatic potential. Although context-specific anti-tumor effects have been reported, the predominant evidence supports a largely pro-tumorigenic and pro-metastatic role for platelets. Elucidating the molecular mechanisms underlying platelet-tumor interactions is therefore essential for improving cancer risk stratification, prognostic evaluation, and therapeutic development. This review summarizes current advances in platelet-derived biomarkers and discusses emerging therapeutic strategies targeting platelet-mediated pathways to suppress metastasis and improve clinical outcomes in cancer patients.
如何引用
AMA
Amir Hossein Kheirkhah, Tahereh Zarei Taher, Zahra Khosrowpour, Omid Mahmoudian, Maria Kavianpour. The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.. Cancer biology & therapy. 2026; doi:10.1080/15384047.2026.2692154.
APA
Amir Hossein Kheirkhah, Tahereh Zarei Taher, Zahra Khosrowpour, Omid Mahmoudian, Maria Kavianpour (2026). The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.. Cancer biology & therapy. https://doi.org/10.1080/15384047.2026.2692154
GB/T 7714
Amir Hossein Kheirkhah, Tahereh Zarei Taher, Zahra Khosrowpour, Omid Mahmoudian, Maria Kavianpour. The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.[J]. Cancer biology & therapy, 2026 doi:10.1080/15384047.2026.2692154.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出