三阴性乳腺癌症的肿瘤微环境，以及使用冷冻消融和免疫刺激剂改善免疫疗法反应的策略
The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.
摘要(中文译文)
每八名女性中就有一人在其一生中会罹患乳腺癌（BC）。三阴性乳腺癌（TNBC）占乳腺癌病例的20%，与其他乳腺癌亚型相比，其治疗选择更少、转移潜能更大、复发风险更高、预后更差。与激素受体阳性乳腺癌相比，TNBC具有更多的肿瘤浸润淋巴细胞、更高的肿瘤突变负荷以及更高的程序性死亡配体-1（PD-L1）表达。尽管这些特征提示更强的免疫原性，但复杂的TNBC肿瘤微环境（TME）的平衡却是免疫抑制性的。TME导致免疫检查点抑制剂（ICI）对TNBC的疗效有限且多变。本综述探讨了TNBC功能失调的免疫状态，并提出了一种多模式策略，将冷冻消融作为肿瘤相关抗原（TAAs）的来源与免疫刺激剂相结合，以重编程抗肿瘤免疫。本综述特别探讨了将ICI和免疫刺激剂与作为TAA来源的冷冻消融相联合的策略。
Abstract
One in eight women will develop breast cancer (BC) over their lifetime. Triple-negative breast cancer (TNBC) accounts for up to 20% of BC cases and has fewer treatment options, greater metastatic potential, a higher risk of recurrence, and a poorer prognosis compared to other BC subtypes. Compared to hormone receptor-positive BCs, TNBC has more tumor-infiltrating lymphocytes, a higher tumor mutational burden, and greater programmed death ligand-1 (PD-L1) expression. While these features suggest greater immunogenicity, the balance of the complex TNBC tumor microenvironment (TME) is immunosuppressive. The TME leads to modest and variable effects of immune checkpoint inhibitors (ICI) for TNBC. This review explores the dysfunctional immunological state of TNBC and proposes a multi-modal strategy integrating cryoablation as a source of tumor-associated antigens (TAAs) and immunostimulatory agents to reprogram antitumor immunity. It specifically explores the strategy of combining ICI and immunostimulants with cryoablation as a source of TAAs.
如何引用
AMA
Ritvik Illindala, Yunpeng Yang, Tyler Mandt, Nicholas Webster, Nicole Steinmetz, Isabel Newton. The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.. Cancer biology & therapy. 2026; doi:10.1080/15384047.2026.2683942.
APA
Ritvik Illindala, Yunpeng Yang, Tyler Mandt, Nicholas Webster, Nicole Steinmetz, Isabel Newton (2026). The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.. Cancer biology & therapy. https://doi.org/10.1080/15384047.2026.2683942
GB/T 7714
Ritvik Illindala, Yunpeng Yang, Tyler Mandt, Nicholas Webster, Nicole Steinmetz, Isabel Newton. The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.[J]. Cancer biology & therapy, 2026 doi:10.1080/15384047.2026.2683942.
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