降钙素原前体评估作为老年社区获得性肺炎患者脓毒症早期生物标志物的研究

摘要(中文译文)

肺炎是脓毒症最常见的病因，早期识别脓毒症至关重要。可溶性CD14亚型（presepsin）是一种新兴生物标志物。为分析presepsin对脓毒症的诊断效能并评估其预测准确性，开展了一项为期18个月的研究，纳入100例确诊社区获得性肺炎（CAP）且符合全身炎症反应综合征（SIRS）标准的老年（≥60岁）患者。记录临床资料并计算快速序贯器官衰竭评估（qSOFA）评分，测定presepsin值并与培养结果进行相关性分析。将所有患者分为两组：诊断组（基于培养结果）和预后组（基于临床结局）。诊断组分为培养阳性亚组和培养阴性亚组，预后组分为存活亚组和死亡亚组。培养阳性患者和死亡患者的presepsin值更高。presepsin与qSOFA评分呈正相关。presepsin不仅可作为预测菌血症的优越生物标志物，还可用于预测脓毒症患者的死亡风险。

Abstract

Pneumonia is the most prevalent cause of sepsis. Early detection of sepsis is essential. Presepsin is an emerging biomarker. To analyze the diagnostic efficacy of presepsin for identifying sepsis and evaluate its predictive accuracy, a study was conducted for 18 months involving 100 elderly (≥60 years) patients diagnosed with community-acquired pneumonia (CAP) and fulfilling the Systemic Inflammatory Response Syndrome (SIRS) criteria. Clinical details were recorded, and the quick Sequential Organ Failure Assessment (qSOFA) score was calculated. Presepsin values were determined and correlated with culture findings. All patients were divided into two groups: the diagnostic group (based on culture findings) and the prognostic group (based on clinical outcome). Subgroups of the diagnostic group were culture-proven and culture-sterile, and those of the prognostic group were survivors and nonsurvivors. Presepsin values were higher in culture-proven patients and nonsurvivors. Presepsin and qSOFA scores correlated positively. Presepsin can be used to predict mortality from sepsis in addition to being a superior biomarker for predicting bacteremia.

如何引用

The Journal of the Association of Physicians of India 的其他文献

• 印度专家对女性变应性鼻炎的共识：改良德尔菲调查
• 急诊科和重症监护室入院的脓毒症患者qSOFA评分和NEWS2评分作为患者预后指标的比较
• 胆结石和酒精以外的急性胰腺炎
• 拉贾斯坦邦农村贫血筛查和管理电子健康倡议