GLP-1受体激动剂治疗期间饮食体验的改变：食物偏好和营养行为的感官喜好框架
Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.
摘要(中文译文)
进食体验不仅由口腔感觉输入塑造，还受享乐评价、内感受状态和线索驱动动机的影响。胰高血糖素样肽-1受体激动剂（GLP-1RAs）广泛用于肥胖治疗，为研究这些过程在食欲调节中如何相互作用提供了一个具有临床相关性的模型。部分接受GLP-1RAs治疗的患者报告食物味道不同、愉悦感降低或诱惑力减弱，但这些体验常被笼统归为“味觉改变”。本综述主张，此类报告应通过感觉-喜好-欲求框架加以解读，而非视为一致性味觉障碍的证据。我们综合了外周味觉信号传导、脑干内感受整合和中枢食物奖赏通路的证据。现有证据并不支持GLP-1RA治疗期间存在一致的原发性基本味觉功能损害。相反，进食体验的改变似乎更符合状态依赖性的食物价值重估和奖赏驱动动机的降低。然而，这些反应具有异质性，部分个体可能表现为反应有限、食欲持续、体重反弹或非典型行为表型。该框架可能有助于阐明基于肠促胰岛素的疗法如何影响食物偏好、膳食摄入、营养行为和治疗依从性。
Abstract
Eating experience is shaped not only by oral sensory input, but also by hedonic evaluation, interoceptive state, and cue-driven motivation. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used for obesity treatment, offer a clinically relevant model for examining how these processes interact during appetite regulation. Some patients receiving GLP-1RAs report that food tastes different, is less enjoyable, or becomes less tempting, yet these experiences are often grouped together as "taste changes." This review argues that such reports should be interpreted through a sensory-liking-wanting framework rather than as evidence of a uniform gustatory disorder. We synthesise evidence from peripheral taste signalling, brainstem interoceptive integration, and central food reward pathways. Current evidence does not support a consistent primary impairment of basic gustatory function during GLP-1RA treatment. Instead, altered eating experience appears more consistent with state-dependent food revaluation and reduced reward-driven motivation. However, these responses are heterogeneous and may include limited response, persistent appetite, weight regain, or atypical behavioural phenotypes in some individuals. This framework may help clarify how incretin-based therapies influence food preference, dietary intake, nutritional behaviour, and treatment adherence.
如何引用
AMA
Jiayi Du, Zhuo Yang, Yan Chen. Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1870484.
APA
Jiayi Du, Zhuo Yang, Yan Chen (2026). Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1870484
GB/T 7714
Jiayi Du, Zhuo Yang, Yan Chen. Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1870484.
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