年轻女性地中海饮食依从性的FTO rs9939609基因型和行为决定因素：对潜在代谢相关性的探索性见解
FTO rs9939609 genotype and behavioral determinants of Mediterranean diet adherence in young women: exploratory insights into potential metabolic relevance.
摘要(中文译文)
代谢紊乱如肥胖和胰岛素抵抗是遗传、行为和饮食因素之间复杂相互作用的结果。脂肪量和肥胖相关（FTO）基因已被多次证实与食欲控制受损及更高的肥胖风险相关，然而功能性饮食模式（如地中海饮食）的调节作用仍不明确。地中海饮食富含生物活性化合物且具有代谢益处，为研究基因-饮食相互作用对代谢健康的影响提供了模型。本初步研究旨在提供一种整合性视角，将FTO rs9939609基因型与不同体重特征女性的进食相关情绪、习惯性行为及地中海式饮食依从性相关联。本初步研究考察了46名18-35岁女性（正常体重：n=24；超重或肥胖：n=22）中FTO rs9939609基因型、进食行为与地中海饮食依从性之间的关联。进食行为采用进食相关行为问卷（QERB）评估，饮食质量采用地中海金字塔（MedPyr）指数评价。基因分型通过Sanger测序完成。超重或肥胖女性表现出更高的BMI（P<0.001）和更严重的习惯性暴食（P=0.007），尤其在携带FTO AT/AA基因型的超重或肥胖者中更为明显。QERB总分在TT亚组（P=0.037）和AT/AA亚组（P=0.005）中均较高。在MedPyr总体依从性方面未观察到显著的基因型或BMI相关差异。然而，携带AT/AA基因型的超重或肥胖者报告更频繁的蔬菜摄入（P=0.037），而AT/AA对照组则更常食用鸡蛋（P=0.015）。坚持地中海饮食这一富含多酚、纤维和不饱和脂肪的功能性饮食模式，可能与肥胖风险相关的遗传易感性发生交互作用。这些探索性发现提示，饮食环境可能塑造FTO风险等位基因携带者的行为倾向，但仍需在更大样本中加以验证。
Abstract
Metabolic disorders such as obesity and insulin resistance result from complex interactions between genetic, behavioral, and dietary factors. The fat mass and obesity-associated (FTO) gene has been repeatedly linked to impaired appetite control and higher obesity risk, yet the moderating role of functional dietary patterns such as the Mediterranean diet remain unclear. Rich in bioactive compounds and metabolic benefits, this diet offers a model for studying gene-diet interactions in metabolic health. This pilot investigation aimed to provide an integrative perspective linking the FTO rs9939609 genotype with eating-related emotions, habitual behavior, and adherence to a Mediterranean-style diet in women with different body weight profiles. This pilot study examined associations between the FTO rs9939609 genotype, eating behaviors, and adherence to the Mediterranean diet among 46 women aged 18-35 years (normal weight: = 24; overweight or obesity: = 22). Eating behaviors were assessed with the Questionnaire of Eating-Related Behaviors (QERB), and diet quality was evaluated using the Mediterranean Pyramid (MedPyr) index. Genotyping was performed by Sanger sequencing. Women with overweight or obesity showed higher BMI ( < 0.001) and greater habitual overeating ( = 0.007), particularly among FTO AT/AA carriers with overweight or obesity. Total QERB scores were higher in both TT ( = 0.037) and AT/AA ( = 0.005) subgroups. No significant genotype- or BMI-related differences were observed in overall MedPyr adherence. However, AT/AA carriers with overweight or obesity reported more frequent vegetable intake ( = 0.037), while AT/AA controls consumed eggs more often ( = 0.015). Adherence to the Mediterranean diet, a functional dietary pattern rich in polyphenols, fiber, and unsaturated fats, may interact with genetic predispositions related to obesity risk. These exploratory findings suggest that dietary context may shape behavioral tendencies in FTO risk-allele carriers, although confirmation in larger samples is required.
如何引用
AMA
Małgorzata Obara-Gołębiowska, Katarzyna Eufemia Przybyłowicz, Anna Danielewicz, Tomasz Sawicki. FTO rs9939609 genotype and behavioral determinants of Mediterranean diet adherence in young women: exploratory insights into potential metabolic relevance.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1771565.
APA
Małgorzata Obara-Gołębiowska, Katarzyna Eufemia Przybyłowicz, Anna Danielewicz, Tomasz Sawicki (2026). FTO rs9939609 genotype and behavioral determinants of Mediterranean diet adherence in young women: exploratory insights into potential metabolic relevance.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1771565
GB/T 7714
Małgorzata Obara-Gołębiowska, Katarzyna Eufemia Przybyłowicz, Anna Danielewicz, Tomasz Sawicki. FTO rs9939609 genotype and behavioral determinants of Mediterranean diet adherence in young women: exploratory insights into potential metabolic relevance.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1771565.
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