糖尿病球后血流动力学改变：眼动脉和视网膜中央动脉的多普勒评估
Retrobulbar Hemodynamic Alterations in Diabetes Mellitus: Doppler Evaluation of the Ophthalmic and Central Retinal Arteries.
摘要(中文译文)
糖尿病可引起微血管改变，进而促进糖尿病视网膜病变的发生发展。球后循环的血流动力学变化可能早于临床可检测的视网膜损害出现。本研究旨在比较糖尿病参与者与非糖尿病对照者之间眼动脉（OA）和视网膜中央动脉（CRA）的多普勒血流动力学指标。本横断面观察性研究纳入76名参与者（38名糖尿病参与者和38名非糖尿病对照者），共分析152只眼（以眼为单位进行分析）。采用彩色多普勒成像测量OA和CRA的收缩期峰值流速（PSV）、舒张末期流速（EDV）、阻力指数（RI）及收缩期/舒张期（S/D）比值。组间比较采用独立样本t检验，统计学显著性设定为p < 0.05。糖尿病参与者球后动脉的血管阻力显著升高。糖尿病参与者的OA-RI显著高于非糖尿病对照者（0.80 ± 0.03 vs. 0.71 ± 0.01；p < 0.001）。CRA-RI同样升高（0.70 ± 0.04 vs. 0.62 ± 0.01；p < 0.001）。糖尿病参与者球后血流速度显著降低，包括OA-PSV（19.38 ± 2.71 vs. 29.18 ± 1.42 cm/s；p < 0.001）和OA-EDV（3.84 ± 1.04 vs. 8.49 ± 0.53 cm/s；p < 0.001）。CRA-PSV（9.02 ± 1.23 vs. 13.28 ± 0.64 cm/s；p < 0.001）和CRA-EDV（2.87 ± 0.82 vs. 5.05 ± 0.33 cm/s；p < 0.001）亦显著降低。糖尿病参与者两条血管的S/D比值均显著升高。糖尿病与OA和CRA血管阻力增加及血流速度降低相关。这些发现提示，彩色多普勒成像可能有助于识别与糖尿病视网膜疾病相关的眼循环早期血流动力学改变。
Abstract
Diabetes mellitus causes microvascular alterations that contribute to the development of diabetic retinopathy. Hemodynamic changes in retrobulbar circulation may occur before clinically detectable retinal damage. This study aimed to compare Doppler hemodynamic indices of the ophthalmic artery (OA) and central retinal artery (CRA) between diabetic participants and non-diabetic controls. This cross-sectional observational study included 76 participants (38 diabetic participants and 38 non-diabetic controls), comprising 152 eyes analyzed at the eye level. Color Doppler imaging was used to measure peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI), and systolic/diastolic (S/D) ratio in the OA and CRA. Group comparisons were performed using an independent samples t-test, with statistical significance set at p < 0.05. Diabetic participants demonstrated significantly higher vascular resistance in retrobulbar arteries. OA-RI was significantly higher in diabetic participants (0.80 ± 0.03) than in non-diabetic controls (0.71 ± 0.01; p < 0.001). CRA-RI was similarly elevated (0.70 ± 0.04 vs. 0.62 ± 0.01; p < 0.001). Retrobulbar blood flow velocities were significantly reduced in diabetic participants, including OA-PSV (19.38 ± 2.71 vs. 29.18 ± 1.42 cm/s; p < 0.001) and OA-EDV (3.84 ± 1.04 vs. 8.49 ± 0.53 cm/s; p < 0.001). CRA-PSV (9.02 ± 1.23 vs. 13.28 ± 0.64 cm/s; p < 0.001) and CRA-EDV (2.87 ± 0.82 vs. 5.05 ± 0.33 cm/s; p < 0.001) were also significantly reduced. S/D ratios were significantly elevated in both vessels among diabetic participants. Diabetes is associated with increased vascular resistance and reduced blood flow velocities in the OA and CRA. These findings suggest that color Doppler imaging may help identify early hemodynamic alterations in the ocular circulation associated with diabetic retinal disease.
如何引用
AMA
Kotresh N S, Vinutha H, ApoorvaPooja K, Prajwal M P. Retrobulbar Hemodynamic Alterations in Diabetes Mellitus: Doppler Evaluation of the Ophthalmic and Central Retinal Arteries.. Cureus. 2026; doi:10.7759/cureus.111625.
APA
Kotresh N S, Vinutha H, ApoorvaPooja K, Prajwal M P (2026). Retrobulbar Hemodynamic Alterations in Diabetes Mellitus: Doppler Evaluation of the Ophthalmic and Central Retinal Arteries.. Cureus. https://doi.org/10.7759/cureus.111625
GB/T 7714
Kotresh N S, Vinutha H, ApoorvaPooja K, Prajwal M P. Retrobulbar Hemodynamic Alterations in Diabetes Mellitus: Doppler Evaluation of the Ophthalmic and Central Retinal Arteries.[J]. Cureus, 2026 doi:10.7759/cureus.111625.
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