骨关节炎免疫治疗中金属基纳米材料的多模式调节：当前格局和未来范式
Multimodal modulation of metal-based nanomaterials in osteoarthritis immunotherapy: current landscape and future paradigms.
摘要(中文译文)
骨关节炎（OA）是一种以免疫代谢失调、氧化应激和慢性炎症为特征的退行性关节疾病。目前的治疗方法只能缓解症状，无法阻止疾病进展。金属基纳米材料（MNMs）近年来作为创新的免疫调节剂用于OA治疗而崭露头角。本综述总结了OA中的关键免疫病理机制，如巨噬细胞极化失衡、NLRP3炎症小体激活和铁死亡，并探讨了MNMs如何通过清除活性氧（ROS）、重编程巨噬细胞和靶向抑制炎症信号通路来减轻这些过程。我们还重点介绍了先进的材料设计策略，如表面功能化和刺激响应性药物释放，以提高靶向性和疗效。尽管临床前结果令人鼓舞，但长期生物安全性和临床转化方面的挑战仍然存在。未来的工作应集中于合理的纳米材料设计、利用先进组学技术开展的机制研究，以及开发更符合生理条件的疾病模型，以促进临床应用。
Abstract
Osteoarthritis (OA) is a degenerative joint disease characterized by immune-metabolic dysregulation, oxidative stress, and chronic inflammation. Current therapies offer symptomatic relief but do not halt disease progression. Metal-based nanomaterials (MNMs) have recently emerged as innovative immunomodulatory agents for OA treatment. This review summarizes key immune-pathological mechanisms in OA, such as macrophage polarization imbalance, NLRP3 inflammasome activation, and ferroptosis, and examines how MNMs mitigate these processes via ROS scavenging, macrophage reprogramming, and targeted inhibition of inflammatory signaling. We also highlight advanced material design strategies such as surface functionalization and stimulus-responsive drug release for improved targeting and efficacy. Despite promising preclinical results, challenges related to long-term biosafety and clinical translation remain. Future efforts should focus on rational nanomaterial design, mechanistic studies using advanced omics technologies, and the development of more physiologically relevant disease models to facilitate clinical application.
如何引用
AMA
Jiayi Chen, Jun Ma, Zhuoming Xu, Huanhuan Luo, Haodong Hu, Chenhong Qian, et al. Multimodal modulation of metal-based nanomaterials in osteoarthritis immunotherapy: current landscape and future paradigms.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1827369.
APA
Jiayi Chen, Jun Ma, Zhuoming Xu, Huanhuan Luo, Haodong Hu, Chenhong Qian, et al (2026). Multimodal modulation of metal-based nanomaterials in osteoarthritis immunotherapy: current landscape and future paradigms.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1827369
GB/T 7714
Jiayi Chen, Jun Ma, Zhuoming Xu, Huanhuan Luo, Haodong Hu, Chenhong Qian, et al. Multimodal modulation of metal-based nanomaterials in osteoarthritis immunotherapy: current landscape and future paradigms.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1827369.
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