免疫球蛋白G在衰老和癌症中的作用

摘要(中文译文)

免疫球蛋白是体液免疫中的关键效应分子，通过其复杂的结构-功能关系在人类健康与疾病中发挥基础性作用。免疫球蛋白产生或功能失调是众多疾病的根本原因，包括炎症性疾病、自身免疫性疾病和代谢性疾病。在癌症背景下，免疫球蛋白G（IgG）常富集于肿瘤组织内并表现出异常糖基化，其与癌症进展相关，且其在肿瘤微环境中的功能影响正日益受到关注。此外，近期研究共同鉴定其为一类参与多器官衰老过程的新型衰老相关因子。理解免疫球蛋白在生理和病理条件下的作用及机制仍是研究者的重要优先事项。因此，阐明IgG的潜在病理生理学和机制可能为开发新的治疗策略提供有价值的见解。在本综述中，我们总结了IgG在衰老和癌症中研究的最新进展，并讨论其在免疫学和生物医学研究未来格局中的潜在作用。

Abstract

Immunoglobulins are key effector molecules in humoral immunity and play fundamental roles in human health and disease through their complex structure-function relationships. Dysregulation of immunoglobulin production or function underlies numerous conditions, including inflammatory disorders, autoimmune diseases, and metabolic diseases. In the context of cancer, immunoglobulin G (IgG) is frequently enriched within tumor tissue and displays aberrant glycosylation, where it correlates with cancer progression, and its functional impact within the tumor microenvironment is drawing growing interest. Furthermore, recent studies have collectively identified as a novel aging-associated factor involved in multi-organ aging processes. Understanding the role and the mechanisms of immunoglobulins in both physiological and pathological conditions remain a major priority for researchers. Elucidating the underlying pathophysiology and mechanisms of IgG may therefore provide valuable insights for the development of new therapeutic strategies. In this review, we summarize recent progress in the study of IgG in aging and cancer and discuss its potential roles in the future landscape of immunology and biomedical research.

如何引用

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