调节肠道生态系统饮食、益生菌和绝经后妇女骨骼健康的新干预措施
Modulating the gut ecosystem dietary, probiotic, and novel interventions for bone health in postmenopausal women.
摘要(中文译文)
绝经后骨质疏松症（PMO）是一种由雌激素缺乏引起的代谢性骨病，对中老年女性的骨骼健康和生活质量构成重大风险。近年来，肠道菌群（GM）已成为骨代谢中一个新的调控靶点，引起了越来越多的研究关注。益生菌可能通过直接引入有益微生物（如乳杆菌、双歧杆菌）来改善肠道菌群组成，从而调节骨代谢。肠道菌群可能通过调节免疫炎症反应、内分泌调节、营养吸收以及代谢副产物的产生来影响骨质疏松症的发生和进展。本综述系统总结了肠道菌群影响绝经后骨质疏松症的机制，包括神经内分泌脑-肠-骨轴、免疫调节、短链脂肪酸等代谢产物、肠道屏障功能及其与骨密度的相关性。结合最新的临床和动物模型研究，我们进一步探讨了基于肠道菌群的干预策略，如益生菌、益生元、粪菌移植和饮食调节。这些见解可为绝经后骨质疏松症的预防和治疗提供理论基础和实践指导，突显了靶向肠道菌群的疗法在改善绝经后女性骨骼健康方面的广阔前景。
Abstract
Postmenopausal osteoporosis (PMO) is a metabolic bone disorder caused by estrogen deficiency, posing significant risks to the skeletal health and quality of life of middle-aged and elderly women. In recent years, the gut microbiota (GM) has emerged as a novel regulatory target in bone metabolism, attracting increasing research interest. Probiotics may modulate bone metabolism by directly introducing beneficial microorganisms (e.g., Lactobacillus, Bifidobacterium) to improve gut microbiota composition. The gut microbiota may influence the onset and progression of osteoporosis by modulating immune-inflammatory responses, endocrine regulation, nutrient absorption, and the production of metabolic byproducts. This review systematically summarizes the mechanisms by which gut microbiota affects postmenopausal osteoporosis, including the neuroendocrine brain-gut-bone axis, immune regulation, metabolic products such as short-chain fatty acids, intestinal barrier function, and their correlations with bone mineral density. Integrating the latest clinical and animal model studies, we further explore gut microbiota-based intervention strategies, such as probiotics, prebiotics, fecal microbiota transplantation, and dietary modulation. These insights may provide a theoretical foundation and practical guidance for the prevention and treatment of postmenopausal osteoporosis, highlighting the promising role of gut microbiota-targeted therapies in improving bone health in postmenopausal women.
如何引用
AMA
Ying Lin, Jiayong Zheng, Dongquan Hu, Yaozhe Ying, Yuan Zhu, Zheyan Chen. Modulating the gut ecosystem dietary, probiotic, and novel interventions for bone health in postmenopausal women.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1814866.
APA
Ying Lin, Jiayong Zheng, Dongquan Hu, Yaozhe Ying, Yuan Zhu, Zheyan Chen (2026). Modulating the gut ecosystem dietary, probiotic, and novel interventions for bone health in postmenopausal women.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1814866
GB/T 7714
Ying Lin, Jiayong Zheng, Dongquan Hu, Yaozhe Ying, Yuan Zhu, Zheyan Chen. Modulating the gut ecosystem dietary, probiotic, and novel interventions for bone health in postmenopausal women.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1814866.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出