急性心肌梗死中的白细胞活化与炎症：来自细胞群体数据的新见解
Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data.
摘要(中文译文)
免疫失调与急性心肌梗死（AMI）密切相关，驱动持续性炎症和心肌损伤。除中性粒细胞和单核细胞计数外，还需更好地理解免疫细胞对AMI的应答。细胞群体数据（CPD）分析包括颗粒度（SSC）、大小（FSC）、活化（SFL）及异质性指数，可更深入地揭示白细胞群体的动态变化。本研究旨在探讨CPD作为AMI后心血管（CV）死亡预后生物标志物的价值，并评估其与炎症及脂质标志物的关联。研究纳入572例AMI患者，于入住心内科重症监护病房时采集样本。除常规血液检查外，采用自动化血液分析仪获取CPD。同时测定血浆炎症标志物及详细脂肪酸谱。随后进行一年随访以评估CV死亡。中性粒细胞、单核细胞及未成熟粒细胞（IG）计数以及中性粒细胞荧光异质性（NE-WY）与CV死亡、心肌梗死（MI）及hs-CRP、IL-6等炎症生物标志物相关。相反，淋巴细胞计数与CV死亡及炎症标志物呈负相关。单核细胞计数及CPD与饱和脂肪酸相关，尤其是棕榈酸。研究结果表明，CPD尤其是与中性粒细胞和单核细胞相关的参数，与炎症及CV死亡的发生密切相关。重要的是，这些CPD参数可通过标准临床血液分析仪便捷获取，作为预测性生物标志物具有重要潜力，可帮助临床医生在常规实践中评估心血管风险。
Abstract
Immune dysregulation is strongly involved in acute myocardial infarction (AMI), driving sustained inflammation and myocardial damage. A better understanding of the immune cell response to AMI is needed, beyond neutrophil and monocyte counts. Cell Population Data (CPD) analysis, including granularity (SSC), size (FSC), activation (SFL), and heterogeneity indices, offers deeper insights into the dynamics of leukocyte populations. Our goal was to investigate CPD as prognostic biomarkers for cardiovascular (CV) mortality after AMI and to assess their links to inflammatory and lipid markers. Samples from 572 patients with AMI were collected at the admission in the cardiology intensive care unit. In addition to routine blood tests, CPD was acquired on an automated haematology analyser. Plasma inflammatory markers, as well as detailed fatty acid profiles, were also measured. A one-year follow-up was then conducted to assess CV mortality. Neutrophil, monocyte, and immature granulocyte (IG) counts and neutrophil heterogeneity of fluorescence (NE-WY) were associated with CV deaths, myocardial infarction (MI), and inflammatory biomarkers such as hs-CRP and IL-6. On the opposite, lymphocyte count was inversely associated with CV death and inflammatory markers. Monocyte count and CPD were correlated with saturated fatty acids, especially palmitic acid. Our findings demonstrate that CPD, particularly parameters related to neutrophils and monocytes, are robustly linked to inflammation and the occurrence of CV mortality. Importantly, these CPD-readily accessible through standard clinical haematology analysers-hold significant potential as predictive biomarkers for clinicians to assess cardiovascular risk in routine practice.
如何引用
AMA
Damien Leleu, Maxime Nguyen, Julien Guy, Michel Farnier, Frédéric Chagué, Laurine Collas, et al. Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1864687.
APA
Damien Leleu, Maxime Nguyen, Julien Guy, Michel Farnier, Frédéric Chagué, Laurine Collas, et al (2026). Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1864687
GB/T 7714
Damien Leleu, Maxime Nguyen, Julien Guy, Michel Farnier, Frédéric Chagué, Laurine Collas, et al. Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1864687.
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