肌酸是否改善大鼠模型中皮质类固醇介导的面神经愈合？
Does Creatine Improve Corticosteroid-Mediated Facial Nerve Healing in a Rat Model?
摘要(中文译文)
评估一水肌酸与甲泼尼龙单用或联用对大鼠实验性面神经挤压伤后功能与结构恢复的影响。将四十只Wistar白化大鼠随机分为五组：对照组（0组）、单纯创伤组（1组）、创伤加一水肌酸组（2组）、创伤加甲泼尼龙组（3组）、创伤加联合治疗组（4组）。在面神经下颌缘支建立标准化挤压伤模型。于损伤前、损伤后即刻及术后第28天进行电生理评估。采用光镜和透射电镜进行组织病理学评价。各创伤组间基线及损伤后即刻电生理测量结果具有可比性。术后第28天，与损伤后测量值相比，3组和4组的潜伏期值及复合肌肉动作电位（CMAPs）显著改善（p = 0.0001）。组织病理学分析显示，与1组和2组相比，4组的髓鞘变性减轻（p = 0.006和p = 0.005）。4组的内皮形态与0组相当，而其他创伤组观察到内皮细胞高度增加。总体组织形态学恢复方面，4组最接近0组。一水肌酸与甲泼尼龙联合给药较单药治疗获得更优的组织病理学恢复。尽管皮质类固醇改善了电生理结局，但加入肌酸增强了结构保护，支持其作为辅助治疗的作用。不适用。
Abstract
To evaluate the effects of creatine monohydrate and methylprednisolone, administered individually or in combination, on functional and structural recovery following experimental facial nerve crush injury in rats. Forty Wistar albino rats were randomly allocated into five groups: control (Group 0), trauma only (Group 1), trauma plus creatine monohydrate (Group 2), trauma plus methylprednisolone (Group 3), and trauma plus combined therapy (Group 4). A standardized crush injury was induced in the marginal mandibular branch of the facial nerve. Electrophysiological assessments were performed pre-injury, immediately after injury, and on postoperative Day 28. Histopathological evaluation was conducted using light and transmission electron microscopy. Baseline and immediate post-injury electrophysiological measurements were comparable among trauma groups. On postoperative Day 28, significant improvement in latency values and compound muscle action potentials (CMAPs) was observed in Groups 3 and 4 compared with post-injury measurements (p = 0.0001). Histopathological analysis demonstrated reduced myelin degeneration in Group 4 compared with Groups 1 and 2 (p = 0.006 and p = 0.005). Endothelial morphology in Group 4 was comparable to Group 0, whereas increased endothelial cell height was observed in other trauma groups. Overall histomorphological recovery in Group 4 most closely resembled Group 0. Combined administration of creatine monohydrate and methylprednisolone resulted in superior histopathological recovery compared with monotherapy. While corticosteroids improved electrophysiological outcomes, the addition of creatine enhanced structural preservation, supporting its role as an adjunct therapy. N/A.
如何引用
AMA
Emre Apaydin, Sumeyra Doluoglu, Elif Dagli, Sevinc Bayrak, Ekrem Said Kankilic, Z Aybuke Gazeloglu, et al. Does Creatine Improve Corticosteroid-Mediated Facial Nerve Healing in a Rat Model?. The Laryngoscope. 2026; doi:10.1002/lary.70762.
APA
Emre Apaydin, Sumeyra Doluoglu, Elif Dagli, Sevinc Bayrak, Ekrem Said Kankilic, Z Aybuke Gazeloglu, et al (2026). Does Creatine Improve Corticosteroid-Mediated Facial Nerve Healing in a Rat Model?. The Laryngoscope. https://doi.org/10.1002/lary.70762
GB/T 7714
Emre Apaydin, Sumeyra Doluoglu, Elif Dagli, Sevinc Bayrak, Ekrem Said Kankilic, Z Aybuke Gazeloglu, et al. Does Creatine Improve Corticosteroid-Mediated Facial Nerve Healing in a Rat Model?[J]. The Laryngoscope, 2026 doi:10.1002/lary.70762.
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