微球菌对前庭偏头痛的辅助诊断价值
The Auxiliary Diagnostic Value of Microsaccades in Vestibular Migraine.
摘要(中文译文)
本研究旨在定量分析前庭性偏头痛(VM)患者视频头脉冲试验(vHIT)中的前庭眼反射(VOR)增益及扫视特征，为临床诊断提供依据。本研究纳入30例确诊VM患者(60耳)和30例健康对照者(60耳)。通过vHIT评估六个半规管(SCC)的功能，比较两组间VOR增益及扫视的定量参数。采用Benjamini-Hochberg校正(q<0.05认为有统计学意义)。两组间所有半规管的VOR增益均无显著差异(q>0.05)。然而，在扫视参数分析中，VM组表现出更高的峰速度(q=0.03)和更短的潜伏期(q=0.03)。水平半规管的扫视持续时间及频率以及垂直半规管的任何扫视参数均未观察到组间差异。ROC分析确定了水平半规管首次扫视的最佳截断值：峰速度83.69°/s(曲线下面积：0.668，灵敏度：0.586，特异度：0.8)和潜伏期295.45 ms(曲线下面积：0.666，灵敏度：0.69，特异度：0.582)。尽管VM患者的VOR增益处于正常范围内，但其表现出与健康个体不同的病理性微扫视，特征为水平半规管扫视“高速度、短潜伏期”。这些定量扫视参数有望作为补充传统VOR增益的客观辅助指标，为VM的临床诊断提供辅助证据。证据等级：2
Abstract
This study aims to quantitatively analyze vestibulo-ocular reflex (VOR) gain and saccade characteristics during video head impulse testing (vHIT) in patients with vestibular migraine (VM), providing evidence for clinical diagnosis. This study included 30 definite VM patients (60 ears) and 30 healthy controls (60 ears). The function of six semicircular canals (SCCs) was evaluated by vHIT. Quantitative parameters of VOR gain and saccades were compared between groups. Benjamini-Hochberg correction was applied (q < 0.05 considered significant). No significant differences in VOR gains for all SCCs were found between groups (q > 0.05). However, in the analysis of saccade parameters, the VM group showed higher peak velocity (q = 0.03) and shorter latency (q = 0.03). No group differences were observed in saccade duration or frequency for lateral SCCs, nor in any saccade parameters for vertical SCCs. ROC analysis identified optimal cutoffs for the first lateral SCC saccade: peak velocity of 83.69°/s (AUC: 0.668, sensitivity: 0.586, specificity: 0.8) and latency of 295.45 ms (AUC: 0.666, sensitivity: 0.69, specificity: 0.582). Although VOR gains in VM patients fall within the normal range, they exhibit pathological microsaccades that differ from those of healthy individuals, characterized by lateral SCC saccades with "high velocity and short latency." These quantitative saccade parameters hold promise as supplementary objective indicators to complement traditional VOR gain, offering auxiliary evidence for the clinical diagnosis of VM. LEVEL OF EVIDENCE: 2
如何引用
AMA
Jianhui Qiu, Mingwei Xu, Qin Zhang, Yang Liu, Qiong Wu, Yuan Yao, et al. The Auxiliary Diagnostic Value of Microsaccades in Vestibular Migraine.. The Laryngoscope. 2026; doi:10.1002/lary.70698.
APA
Jianhui Qiu, Mingwei Xu, Qin Zhang, Yang Liu, Qiong Wu, Yuan Yao, et al (2026). The Auxiliary Diagnostic Value of Microsaccades in Vestibular Migraine.. The Laryngoscope. https://doi.org/10.1002/lary.70698
GB/T 7714
Jianhui Qiu, Mingwei Xu, Qin Zhang, Yang Liu, Qiong Wu, Yuan Yao, et al. The Auxiliary Diagnostic Value of Microsaccades in Vestibular Migraine.[J]. The Laryngoscope, 2026 doi:10.1002/lary.70698.
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