针对帕金森病的神经炎症和神经变性：新兴的自然和合成治疗策略
Targeting neuroinflammation and neurodegeneration in Parkinson's disease: Emerging natural and synthetic therapeutic strategies.
摘要(中文译文)
帕金森病（PD）是全球第二大常见的神经退行性疾病。该病与黑质中多巴胺能神经元的持续变性以及包含α-突触核蛋白的路易小体的形成有关。这些病理改变导致运动症状（震颤、强直、运动迟缓）和非运动症状（认知功能下降、睡眠异常、精神异常）的异常。帕金森病的发病机制复杂且涉及多种因素，包括氧化应激、线粒体功能障碍、神经炎症、自噬受损、铁死亡和遗传因素等相互关联的机制。为开发有效的治疗干预措施，需要理解这些通路。目前的治疗方法，如左旋多巴和深部脑刺激（DBS），均基于症状控制，不能阻止疾病进展。因此，大量研究工作致力于寻找疾病修饰治疗策略。天然生物活性化合物、基因治疗、干细胞治疗和纳米技术辅助的药物递送系统是近期进展所提示的有前景的替代方案。姜黄素、白藜芦醇和表没食子儿茶素没食子酸酯（EGCG）等抗氧化化合物显示出有前景的抗氧化和神经保护作用，而纳米医学提供了增强的脑部递送和靶向药物分布。在未来的临床应用中，这些新策略可能有助于更有效、更持久地管理帕金森病。
Abstract
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. It is associated with the ongoing degeneration of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies that contain α-synuclein. These pathological changes lead to abnormalities of motor symptoms (tremor, rigidity, bradykinesia) and non-motor symptoms (cognitive decline, sleep abnormalities, psychiatric abnormalities). The pathogenesis of PD is complex and multifactorial, involving interconnected mechanisms such as oxidative stress, mitochondrial dysfunction, neuroinflammation, impaired autophagy, ferroptosis, and genetic factors. To develop effective therapeutic interventions, these pathways need to be understood. Current treatments, such as levodopa and deep-brain stimulation (DBS), are symptom-based and do not break disease progression. Thus, considerable research efforts have been geared towards finding disease-modifying therapeutic strategies. Natural bioactive compounds, gene-based therapies, stem cell-based therapies, and nanotechnology-assisted drug delivery systems are promising alternatives as suggested by recent advances. Antioxidant compounds like curcumin, resveratrol, and epigallocatechin gallate (EGCG) show promising antioxidant and neuroprotective effects, and nanomedicine provides boosted delivery to the brain and targeted drug distribution. In future clinical applications, these new strategies could help to more effectively and permanently manage PD.
如何引用
AMA
Safia Arbab, Hanif Ullah, Yanting Han, Jiao Zhou, Li Ka. Targeting neuroinflammation and neurodegeneration in Parkinson's disease: Emerging natural and synthetic therapeutic strategies.. Ageing research reviews. 2026; doi:10.1016/j.arr.2026.103263.
APA
Safia Arbab, Hanif Ullah, Yanting Han, Jiao Zhou, Li Ka (2026). Targeting neuroinflammation and neurodegeneration in Parkinson's disease: Emerging natural and synthetic therapeutic strategies.. Ageing research reviews. https://doi.org/10.1016/j.arr.2026.103263
GB/T 7714
Safia Arbab, Hanif Ullah, Yanting Han, Jiao Zhou, Li Ka. Targeting neuroinflammation and neurodegeneration in Parkinson's disease: Emerging natural and synthetic therapeutic strategies.[J]. Ageing research reviews, 2026 doi:10.1016/j.arr.2026.103263.
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