骨髓间充质干细胞在骨老化中的老化：机制、影响和治疗前景
Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.
摘要(中文译文)
骨骼衰老是机体衰退的标志性特征，也是骨质疏松症和骨关节炎等常见年龄相关疾病的基础。骨髓来源间充质干细胞（BMSCs）是成骨细胞的主要来源，在衰老过程中经历深刻的功能退化，导致骨形成与骨吸收之间的失衡。本综述系统总结了BMSC衰老的关键特征，包括增殖与分化能力受损、表观遗传失调以及获得促炎性衰老相关分泌表型（SASP）。我们重点介绍了表观遗传机制（DNA甲基化、组蛋白修饰、RNA甲基化及非编码RNA）如何调控BMSC衰老的最新研究进展。此外，我们讨论了衰老BMSC与骨微环境之间复杂的相互作用，强调其对年龄相关骨疾病的贡献。最后，我们提出了未来的研究方向，包括多组学、单细胞技术的整合及靶向表观遗传干预，以及衰老细胞清除药物、代谢调节剂和基于细胞外囊泡的方法等新兴治疗策略。对BMSC衰老的更深入理解将有助于开发维护骨骼健康和对抗衰老相关骨骼疾病的新型治疗方法。
Abstract
Aging of the skeleton is a hallmark of organismal decline and underlies prevalent age-related disorders such as osteoporosis and osteoarthritis. Bone marrow-derived mesenchymal stem cells (BMSCs), the primary source of osteoblasts, undergo profound functional deterioration during senescence, leading to an imbalance between bone formation and resorption. This review systematically summarizes the key features of BMSC senescence, including impaired proliferation and differentiation, epigenetic dysregulation, and the acquisition of a pro-inflammatory senescence-associated secretory phenotype (SASP). We highlight recent advances in understanding how epigenetic mechanisms (DNA methylation, histone modifications, RNA methylation, and non-coding RNAs) orchestrate BMSC aging. In addition, we discuss the intricate crosstalk between senescent BMSCs and the bone microenvironment, emphasizing their contribution to age-related bone diseases. Finally, we propose future research directions, including the integration of multi‑omics, single-cell technologies, and targeted epigenetic interventions, as well as emerging therapeutic strategies such as senolytics, metabolic modulators, and extracellular vesicle-based approaches. A deeper understanding of BMSC aging will facilitate the development of novel treatments to preserve bone health and combat aging-related skeletal disorders.
如何引用
AMA
Zimo Zhou, Heran Wang, Zhuoru Jin, Boya Wen, Tong Wu, Tiantong Zhu, et al. Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.. Ageing research reviews. 2026; doi:10.1016/j.arr.2026.103240.
APA
Zimo Zhou, Heran Wang, Zhuoru Jin, Boya Wen, Tong Wu, Tiantong Zhu, et al (2026). Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.. Ageing research reviews. https://doi.org/10.1016/j.arr.2026.103240
GB/T 7714
Zimo Zhou, Heran Wang, Zhuoru Jin, Boya Wen, Tong Wu, Tiantong Zhu, et al. Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.[J]. Ageing research reviews, 2026 doi:10.1016/j.arr.2026.103240.
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