线粒体转移中的免疫调节：从文献计量学角度的知识结构和新兴趋势

摘要(中文译文)

线粒体转移已成为一种重要的细胞间通讯形式，与免疫调节、炎症、组织修复和肿瘤免疫的相关性日益增强。然而，该领域的知识结构、发展轨迹和新兴热点仍不明确。我们对2016年至2025年间发表的关于线粒体转移与免疫调节的研究进行了文献计量学分析。文献检索自PubMed、Embase、Cochrane Library、Scopus和Web of Science，并使用R语言中的bibliometrix软件包和CiteSpace进行分析。评估了年度发文趋势，国家、机构、作者和期刊的贡献，以及关键词共现、聚类、突现检测和共被引模式。共纳入967篇文献。年度发文量稳步增长，2020年后增长加快。中国和美国是主要贡献者，并在国际合作网络中占据中心位置。关键词和共被引分析显示，早期研究主要集中于线粒体DNA相关的炎症感知、先天免疫和炎症损伤，而近期研究日益强调细胞间线粒体转移、线粒体移植、T细胞功能、肿瘤相关巨噬细胞、癌症免疫治疗、代谢重编程和自噬相关的线粒体质量控制。线粒体移植和隧道纳米管是最突出的突现术语之一。共被引分析识别出与线粒体危险信号、细胞间转移机制、间充质干细胞介导的免疫调节、肿瘤免疫和转化应用相关的主要知识领域。文献计量学图谱显示，该领域从线粒体危险信号明显转向细胞间转移和免疫细胞代谢重塑。当前证据表明，免疫结局受线粒体来源、转移途径、受体细胞状态和疾病背景的影响。需要更多来源明确且背景特异性的研究来阐明线粒体转移的治疗潜力。

Abstract

Mitochondrial transfer has emerged as an important form of intercellular communication with growing relevance to immune regulation, inflammation, tissue repair, and tumor immunity. However, the knowledge structure, developmental trajectory, and emerging hotspots of this field remain unclear. We conducted a bibliometric analysis of studies on mitochondrial transfer and immune regulation published between 2016 and 2025. Publications were retrieved from PubMed, Embase, the Cochrane Library, Scopus, and Web of Science, and analyzed using bibliometrix in R and CiteSpace. Annual publication trends, contributions of countries, institutions, authors, and journals, as well as keyword co-occurrence, clustering, burst detection, and co-citation patterns were evaluated. A total of 967 publications were included. Annual publication output increased steadily, with faster growth after 2020. China and the United States were the leading contributors and occupied central positions in international collaboration networks. Keyword and co-citation analyses showed that early studies mainly focused on mitochondrial DNA-associated inflammatory sensing, innate immunity, and inflammatory injury, whereas recent studies increasingly emphasized intercellular mitochondrial transfer, mitochondrial transplantation, T-cell function, tumor-associated macrophages, cancer immunotherapy, metabolic rewiring, and autophagy-associated mitochondrial quality control. Mitochondrial transplantation and tunneling nanotube were among the most prominent burst terms. Co-citation analysis identified major knowledge domains related to mitochondrial danger signaling, intercellular transfer mechanisms, mesenchymal stem cell-mediated immune regulation, tumor immunity, and translational applications. Bibliometric mapping shows a clear shift from mitochondrial danger signaling toward intercellular transfer and immune-cell metabolic remodeling. Current evidence suggests that immune outcomes are shaped by mitochondrial source, transfer route, recipient-cell state, and disease context. More source-defined and context-specific studies are needed to clarify the therapeutic potential of mitochondrial transfer.

如何引用

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