{“_”：“黄芪及其衍生物在消化系统疾病中的作用：免疫耐受的重建。”，“i”：[“黄芪”]}
{"_":"The role of and its derivatives in digestive system diseases: reconstruction of immune tolerance.","i":["Astragalus membranaceus"]}
摘要(中文译文)
胃肠道是人体重要的免疫器官，是与外界抗原直接接触的主要部位。维持免疫耐受对于预防消化系统疾病的发生和进展至关重要。自身免疫性疾病和肿瘤分别代表免疫系统的过度激活和免疫逃逸，而“免疫耐受”失衡是二者共同的核心机制。中药在调节消化系统免疫功能方面的作用已引起广泛关注，尤其是在免疫耐受的双向调节方面。及其衍生物在恢复免疫耐受方面表现出显著疗效。在机制上，这些药物通过调控核心信号通路、重塑免疫细胞功能和肠道菌群组成发挥多靶点调节作用。同时，它们重新平衡关键免疫轴，如Th1/Th2和Treg/Th17，从而系统性地恢复免疫稳态，而非发挥孤立的、单向的调节作用。本综述系统总结了2020年12月至2025年12月发表于PubMed、Web of Science和中国知网的112项研究，聚焦于及其衍生物治疗消化系统疾病的免疫调节机制和证据。本综述进一步探讨了当前研究的局限性及未来潜在的研究方向，从而为开发源自及其活性化合物的新型药物提供理论依据。
Abstract
The gastrointestinal tract, a vital immune organ in the human body, serves as the primary site of direct contact with external antigens. Maintaining immune tolerance is essential for preventing the onset and progression of digestive system diseases. Autoimmune diseases and tumors represent the overactivation and evasion of the immune system, respectively, and the imbalance of "immune tolerance" is the common core mechanism underlying both conditions. The function of traditional Chinese medicine in regulating the immune function of the digestive system has attracted wide attention, especially in the dual regulation of immune tolerance. and its derivatives exhibit remarkable efficacy in restoring immune tolerance. Mechanistically, these agents exert multi-target regulatory effects via modulating core signaling pathways, remodeling immune cell function and gut microbiota composition. Concurrently, they rebalance pivotal immune axes, such as Th1/Th2 and Treg/Th17, thereby systematically reinstating immune homeostasis rather than exerting isolated, unilateral modulations. This review systematically summarizes 112 studies published in PubMed, Web of Science and CNKI from December 2020 to December 2025, focusing on the immunomodulatory mechanisms and evidence of and its derivatives in the treatment of digestive diseases. It further examines the limitations of current studies and potential future research directions, thereby offering a theoretical basis for the development of novel drugs derived from and its active compounds.
如何引用
AMA
Xinyue Chang, Xin Zhang, Hanqing Guo, Xinqi Yao, Jun Zhang, Kun Zhuang, et al. {"_":"The role of and its derivatives in digestive system diseases: reconstruction of immune tolerance.","i":["Astragalus membranaceus"]}. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1855390.
APA
Xinyue Chang, Xin Zhang, Hanqing Guo, Xinqi Yao, Jun Zhang, Kun Zhuang, et al (2026). {"_":"The role of and its derivatives in digestive system diseases: reconstruction of immune tolerance.","i":["Astragalus membranaceus"]}. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1855390
GB/T 7714
Xinyue Chang, Xin Zhang, Hanqing Guo, Xinqi Yao, Jun Zhang, Kun Zhuang, et al. {"_":"The role of and its derivatives in digestive system diseases: reconstruction of immune tolerance.","i":["Astragalus membranaceus"]}[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1855390.
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