炎症标志物suPAR与不明原因慢性瘙痒的相关性——来自SOMA的数据。PRU研究
Association of the inflammatory marker suPAR with chronic pruritus of unknown origin - data from the SOMA.PRU study.
摘要(中文译文)
慢性瘙痒（CP）是一种常见且负担沉重的皮肤病学症状，既可发生于慢性特应性皮炎（cAD）等皮肤疾病中，也可表现为发生于未知原因非皮损皮肤的慢性瘙痒（CPUO）。瘙痒慢性化的机制仍知之甚少。与其他持续性躯体症状一致，慢性系统性炎症可能在慢性瘙痒中发挥作用。可溶性尿激酶纤溶酶原激活物受体（suPAR）已被提出作为长期系统性炎症的标志物，但尚未在慢性瘙痒相关研究中加以探讨。研究CPUO患者与cAD患者血清suPAR水平的比较，并探讨suPAR水平与前瞻性临床病程之间可能的关联。我们分析了105名参与者的数据（35例CPUO、40例cAD、30例对照）。在基线和六个月随访时收集临床及患者报告结局。在本研究中，CPUO患者的suPAR水平最高（3.2 ± 2.5 ng/ml），显示出高于对照组的非显著性趋势（2.9 ± 1.1 ng/ml），并且尽管瘙痒强度相似，但显著高于cAD参与者（2.0 ± 0.9 ng/ml，= 0.018）。此外，基线时suPAR水平较高的CPUO参与者在随访时具有更高的平均和最严重瘙痒强度。本研究表明，系统性慢性炎症是CPUO的一个相关方面。特别是，我们推断suPAR可能是与CPUO纵向病程相关的生物标志物。
Abstract
Chronic pruritus (CP) is a frequent and burdensome dermatological symptom that can occur both in skin conditions such as chronic atopic dermatitis (cAD) and as CP on non-lesional skin of unknown origin (CPUO). Mechanisms of pruritus chronicity remain poorly understood. In line with other persistent somatic symptoms, chronic systemic inflammation may play a role in CP. Soluble urokinase plasminogen activator receptor (suPAR) has been proposed as a marker of long-term systemic inflammation, but has not yet been studied in relation to CP. To study serum levels of suPAR in patients with CPUO in comparison to cAD and to study possible associations between suPAR levels and prospective clinical course. We analyzed data from 105 participants (35 CPUO, 40 cAD, 30 controls). Clinical and patient-reported outcomes were collected at baseline and at a six-months follow-up visit. Patients with CPUO had the highest suPAR levels in our study (3.2 ± 2.5 ng/ml), showing a non-significant trend toward higher levels than controls (2.9 ± 1.1 ng/ml) and, despite similar pruritus intensity, significantly higher than participants with cAD (2.0 ± 0.9 ng/ml, = 0.018). Additionally, CPUO participants with higher levels of suPAR at baseline had higher average and worst pruritus intensity in the follow-up visit. This study indicates that systemic chronic inflammation is a relevant aspect of CPUO. In particular, we infer that suPAR may be a biomarker associated with the longitudinal course of CPUO.
如何引用
AMA
Stefan M Kahnert, Lara Jürgens, Leonie Dreher, Christian Schmidt-Lauber, Ansgar Koechel, Gina L Frank, et al. Association of the inflammatory marker suPAR with chronic pruritus of unknown origin - data from the SOMA.PRU study.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1804748.
APA
Stefan M Kahnert, Lara Jürgens, Leonie Dreher, Christian Schmidt-Lauber, Ansgar Koechel, Gina L Frank, et al (2026). Association of the inflammatory marker suPAR with chronic pruritus of unknown origin - data from the SOMA.PRU study.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1804748
GB/T 7714
Stefan M Kahnert, Lara Jürgens, Leonie Dreher, Christian Schmidt-Lauber, Ansgar Koechel, Gina L Frank, et al. Association of the inflammatory marker suPAR with chronic pruritus of unknown origin - data from the SOMA.PRU study.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1804748.
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