肠道微生物群视角下的结直肠癌全景：对突变、表观遗传失调和免疫微环境改变的洞察
Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.
摘要(中文译文)
本综述探讨肠道微生物群如何重塑结直肠癌（CRC）的分子格局，通过关键机制驱动其发生与进展。微生物及其代谢产物引起驱动突变（DNA损伤、信号干扰）并改变表观遗传学（DNA甲基化、组蛋白修饰、非编码RNA），从而促进肿瘤细胞增殖与存活。菌群失调通过损害免疫细胞并增加免疫抑制因子破坏肿瘤免疫微环境（TIME），助长免疫逃逸。本综述整合分子生物学、微生物学和免疫学，表明微生物变化在肿瘤发生中具有因果作用，不同菌种在各肿瘤阶段发挥不同作用。这些见解阐明了CRC的发病机制，并支持基于微生物群的预防、诊断和治疗。靶向微生物/代谢产物或信号通路可降低CRC风险、改善早期检测并增强治疗效果。本综述强调了微生物群靶向治疗的前景，并为未来研究和临床转化提供指导。
Abstract
This review explores how gut microbiota reshapes colorectal cancer (CRC) molecular landscape, driving initiation/progression via key mechanisms. Microbes/metabolites cause driver mutations (DNA damage, signaling interference) and alter epigenetics (DNA methylation, histone modifications, ncRNAs) to boost tumor cell proliferation/survival. Dysbiosis disrupts tumor immune microenvironment (TIME) by impairing immune cells and increasing immunosuppressive factors, fostering immune evasion.Integrating molecular biology, microbiology, and immunology, we show microbial changes are causal in oncogenesis, with species acting distinctly across tumor stages. These insights clarify CRC pathogenesis and support microbiota-based prevention, diagnosis, treatment. Targeting microbes/metabolites or signaling pathways could cut CRC risk, improve early detection, and boost therapy. The review highlights microbiota-targeted therapy's promise and guides future research/clinical translation.
如何引用
AMA
Yunze Li, Ying Yang, Xixia Zhang, Zhe Huang, Xiaoyue Zhang, Junxiong Wen. Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.. Virulence. 2026; doi:10.1080/21505594.2026.2696642.
APA
Yunze Li, Ying Yang, Xixia Zhang, Zhe Huang, Xiaoyue Zhang, Junxiong Wen (2026). Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.. Virulence. https://doi.org/10.1080/21505594.2026.2696642
GB/T 7714
Yunze Li, Ying Yang, Xixia Zhang, Zhe Huang, Xiaoyue Zhang, Junxiong Wen. Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.[J]. Virulence, 2026 doi:10.1080/21505594.2026.2696642.
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