肝脓肿中肺炎克雷伯菌的临床和基因组分析
{"_":"Clinical and genomic profiling of in liver abscesses.","i":["Klebsiella pneumoniae"]}
摘要(中文译文)
肺炎克雷伯菌是一种机会性革兰阴性病原体，可引起多种感染，包括肝脓肿（LA）。这些感染与高毒力肺炎克雷伯菌（hvKp）相关。本研究旨在描述德国一家三级医院2年期间（2022-2023年）肝脓肿患者中肺炎克雷伯菌的临床和分子特征。在记录的111例肝脓肿中，27%（n=30）的病例检测到肺炎克雷伯菌。其中，12例患者为单一微生物肝脓肿。分析了临床元数据，包括患者人口学特征、基础疾病和微生物学检查结果，并将其与基因组数据相关联，以探索遗传特征与临床表现之间的关联。我们鉴定了7例高毒力肺炎克雷伯菌肝脓肿（hvKpLA）和5例非高毒力肺炎克雷伯菌肝脓肿（KpLA）。研究发现，hvKp最常与特定序列型（ST23-KL1、ST86-KL2）和高毒力相关质粒相关。系统发育分析显示遗传多样性较高，未发现医院内传播的证据。值得注意的是，5例患者观察到糖尿病（DM），其可能是严重肺炎克雷伯菌感染的危险因素。总之，单一微生物肺炎克雷伯菌肝脓肿感染中58%的病例由高毒力菌株引起。此外，在所有记录的肝脓肿中，hvKp病例患病率估计为6.3%。这些发现有助于更好地理解hvKp的分子流行病学，并强调整合临床和基因组数据以实现更准确的风险分层和监测的重要性。
Abstract
() is an opportunistic Gram-negative pathogen responsible for a variety of infections, including liver abscesses (LA). These are associated with hypervirulent (hvKp). This study aimed to characterize the clinical and molecular features of from patients with LA at a German tertiary care hospital over a 2-y period (2022-2023). Among 111 recorded LA, was detected in 27% ( = 30) of cases. Of these, 12 patients had monomicrobial LA. Clinical metadata, including patient demographics, underlying diseases, and microbiological findings, were analyzed and correlated with genomic data to explore associations between genetic traits and clinical presentations. We identified seven cases of hypervirulent liver abscesses (hvKpLA) and five cases of non-hypervirulent liver abscesses (KpLA). The study found that hvKp was most commonly associated with specific sequence types (ST23-KL1, ST86-KL2) and hypervirulence-associated plasmids. Phylogenetic analysis revealed high genetic diversity, with no evidence of nosocomial transmission. Notably, diabetes mellitus (DM) was observed for five cases and may represent a risk factor for severe infections. In conclusion, monomicrobial LA infections were caused by hypervirulent strains in 58% of cases. Further, an hvKp case prevalence of 6.3% was estimated among all recorded liver abscesses. These findings contribute to a better understanding of the molecular epidemiology of hvKp and emphasize the importance of integrating clinical and genomic data for more accurate risk stratification and surveillance.
如何引用
AMA
Felix Aurnhammer, Maxim M Baltzer, Jamil Butt, Lisa S Marr, Anca Rath, Baerbel Kieninger, et al. {"_":"Clinical and genomic profiling of in liver abscesses.","i":["Klebsiella pneumoniae"]}. Virulence. 2026; doi:10.1080/21505594.2026.2670805.
APA
Felix Aurnhammer, Maxim M Baltzer, Jamil Butt, Lisa S Marr, Anca Rath, Baerbel Kieninger, et al (2026). {"_":"Clinical and genomic profiling of in liver abscesses.","i":["Klebsiella pneumoniae"]}. Virulence. https://doi.org/10.1080/21505594.2026.2670805
GB/T 7714
Felix Aurnhammer, Maxim M Baltzer, Jamil Butt, Lisa S Marr, Anca Rath, Baerbel Kieninger, et al. {"_":"Clinical and genomic profiling of in liver abscesses.","i":["Klebsiella pneumoniae"]}[J]. Virulence, 2026 doi:10.1080/21505594.2026.2670805.
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