侵袭性中央巨细胞肉芽肿1例
Aggressive Central Giant Cell Granuloma: A Case Report.
摘要(中文译文)
中央巨细胞肉芽肿（CGCG）是一种少见的颌骨良性骨内病变，通常影响年轻女性的下颌骨前部。侵袭性变异型可表现为快速生长、皮质膨胀、疼痛、牙根吸收和复发。本报告呈现一例不寻常的侵袭性CGCG，累及一名20岁女性患者的上颌骨后部，表现为进行性肿胀和面部不对称。影像学评估显示一个边界清晰的膨胀性溶骨性病变，累及右上颌骨及上颌窦。鉴别诊断包括腺瘤样牙源性肿瘤、动脉瘤样骨囊肿、牙源性黏液瘤、成釉细胞瘤及甲状旁腺功能亢进性棕色瘤。组织病理学检查通过显示纤维细胞性间质内多核巨细胞伴出血区域及编织骨形成，证实了诊断。该病变通过手术摘除、刮除术、周围骨成形术及辅助冷冻治疗进行管理。术后经过平稳，尽管在两个月随访时观察到轻度牙龈退缩和局部根间骨丧失。
Abstract
Central giant cell granuloma (CGCG) is an uncommon benign intraosseous lesion of the jaws that typically affects the anterior mandible in young females. Aggressive variants may demonstrate rapid growth, cortical expansion, pain, root resorption, and recurrence. This report presents an unusual case of aggressive CGCG involving the posterior maxilla in a 20-year-old female patient who presented with progressive swelling and facial asymmetry. Radiographic evaluation revealed a well-defined expansile lytic lesion involving the right maxilla and maxillary sinus. Differential diagnoses included adenomatoid odontogenic tumor, aneurysmal bone cyst, odontogenic myxoma, ameloblastoma, and Brown tumor of hyperparathyroidism. Histopathological examination confirmed the diagnosis by demonstrating multinucleated giant cells within a fibrocellular stroma with hemorrhagic areas and woven bone formation. The lesion was managed by surgical enucleation, curettage, peripheral osteoplasty, and adjunctive cryotherapy. The postoperative period was uneventful, although mild gingival recession and localized interradicular bone loss were observed at two-month follow-up.
如何引用
AMA
R Hariharan, Devotta F Andrew, G Satheesh, S Sakthi, Nithish Kumar. Aggressive Central Giant Cell Granuloma: A Case Report.. Cureus. 2026; doi:10.7759/cureus.109573.
APA
R Hariharan, Devotta F Andrew, G Satheesh, S Sakthi, Nithish Kumar (2026). Aggressive Central Giant Cell Granuloma: A Case Report.. Cureus. https://doi.org/10.7759/cureus.109573
GB/T 7714
R Hariharan, Devotta F Andrew, G Satheesh, S Sakthi, Nithish Kumar. Aggressive Central Giant Cell Granuloma: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.109573.
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