经颅直流电刺激对新冠肺炎后综合征神经精神症状的影响：微观状态和功能连接没有变化
Transcranial direct current stimulation in affecting neuropsychiatric symptoms of post-COVID syndrome: No change in microstates and functional connectivity.
摘要(中文译文)
新冠后综合征（PCS）的神经精神症状包括疲劳、脑雾、认知障碍或抑郁和焦虑症状。这些症状在其他诊断中与脑电图（EEG）微状态和功能连接的变化相关。经颅直流电刺激（tDCS）在其他诊断中对缓解上述某些症状有效。主要目的是评估PCS患者在接受tDCS干预后的EEG变化。一项随机对照试验（注册于ISRCTN数据库，编号：ISRCTN10942585）纳入35名参与者（n=33接受了干预），涉及20次tDCS应用（持续四周）（阳极置于F3，阴极置于F4，持续时间30分钟，强度2mA）。参与者被分为活性组（n=16）和假刺激组（n=17）。静息态EEG在基线、两周后（T1）和干预结束后（四周，T2）作为探索性终点进行测量。分析了微状态及F3与F4之间的功能连接；评估了活性组与假刺激组从基线到T1以及从基线到T2变化的差异。26名参与者（活性组n=13，假刺激组n=13）的EEG测量数据纳入统计分析。未发现显著结果。未记录到严重不良事件。我们未发现活性组与假刺激组之间在所选EEG参数上的显著差异。可能的原因包括tDCS参数的选择（电极蒙太奇或刺激持续时间）以及所选用于评估的EEG变量（微状态和功能连接）。这些结果与认知和临床评估的结果一致。然而，EEG终点为探索性的，且该研究主要以临床结果作为统计效能计算依据，因此由于统计效能有限，不能排除微小效应的存在。
Abstract
Neuropsychiatric symptoms of post-covid syndrome (PCS) involve fatigue, brain fog, cognitive impairment, or symptoms of depression and anxiety. These symptoms are in other diagnoses associated with electroencephalography (EEG) changes in microstates and functional connectivity. Transcranial direct current stimulation (tDCS) is effective in alleviating certain abovementioned symptoms in other diagnoses. The main objective was to evaluate EEG changes in PCS patients after tDCS intervention. A randomised control trial (registered in ISRCTN database, No.: ISRCTN10942585) with 35 participants (n = 33 received the intervention) involved 20 applications (over four weeks) of tDCS (anode over F3, cathode over F4, duration 30 min, intensity 2mA). Participants were divided into active (n = 16) and sham (n = 17) groups. Resting-state EEG was measured at baseline, after two weeks (T1), and after the intervention (four weeks, T2) as an exploratory endpoint. Microstates and functional connectivity between F3 and F4 were analysed; differences between active and sham groups in change from baseline to T1 and from baseline to T2 were evaluated. EEG measurements from 26 participants (n = 13 for active and n = 13 for sham group) were included into the statistical analysis. No significant results were found. No serious adverse events were noted. We did not find a significant difference in selected EEG parameters between active and sham groups. The possible reasons include choice of tDCS parameters (electrode montage or stimulation duration), and EEG variables selected for evaluation (microstates and functional connectivity). These results are in line with the results of cognitive and clinical assessment. However, the EEG endpoints were exploratory and the study was primarily powered for clinical results, therefore small effects cannot be excluded due to limited statistical power.
如何引用
AMA
Nina Biačková, Olga Laskov, Andrea Adamová, Václava Piorecká, Jan Štrobl, Stanislav Jiříček, et al. Transcranial direct current stimulation in affecting neuropsychiatric symptoms of post-COVID syndrome: No change in microstates and functional connectivity.. PloS one. 2026; doi:10.1371/journal.pone.0351407.
APA
Nina Biačková, Olga Laskov, Andrea Adamová, Václava Piorecká, Jan Štrobl, Stanislav Jiříček, et al (2026). Transcranial direct current stimulation in affecting neuropsychiatric symptoms of post-COVID syndrome: No change in microstates and functional connectivity.. PloS one. https://doi.org/10.1371/journal.pone.0351407
GB/T 7714
Nina Biačková, Olga Laskov, Andrea Adamová, Václava Piorecká, Jan Štrobl, Stanislav Jiříček, et al. Transcranial direct current stimulation in affecting neuropsychiatric symptoms of post-COVID syndrome: No change in microstates and functional connectivity.[J]. PloS one, 2026 doi:10.1371/journal.pone.0351407.
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