研究声波增强技术™短期效果的可行性研究

摘要(中文译文)

本研究评估了Sonic Augmentation Technology™（SAT），这是一种新型的、基于多迷走神经理论（Polyvagal-informed）的探针，其将持续变化的声学特征以及模拟自主神经调节模式的声学特征融入音乐声景之中。具体而言，本研究考察了SAT是否能改善自我报告的生物行为状态（如放松、缓慢呼吸、内感受清晰度），以及基线功能较差（即自主神经反应性增高和焦虑/抑郁症状较重）的个体在SAT后是否报告生物行为状态有更大改善。研究还试图确定内源性催产素水平是否会发生改变，以及生物行为状态改善更大的个体是否表现出催产素增幅更大。本研究检验了来自四个样本的数据，其中72名参与者以远程方式提供数据，41名参与者以现场方式提供数据。参与者完成了生物行为状态、自主神经反应性和精神症状（即焦虑和抑郁）的自我报告测量。对现场完成研究的参与者通过酶免疫分析法评估唾液催产素（pg/mL），样本在SAT前后采集。SAT后，参与者报告生物行为状态总分以及低唤醒和高唤醒分量表均有显著改善。我们还发现，自主神经反应性、焦虑和抑郁得分高于临界值的参与者报告生物行为状态总分改善更大，高唤醒分量表下降更多。焦虑增加的参与者在低唤醒分量表上观察到更大的下降。提供唾液催产素样本的参与者亚组表现出唾液催产素升高。因此，我们的结果支持SAT作为一种低成本、非侵入性听觉探针在改善健康方面的潜力，尤其是对于经历自主神经调节障碍和精神困难（如焦虑和抑郁）的临床人群。ClinicalTrials.gov注册号：NCT06710886、NCT06902506、NCT06580119和NCT07065227。

Abstract

The current study evaluated Sonic Augmentation Technology™ (SAT), a novel, Polyvagal-informed probe that incorporates continuously varying and acoustic features modeled on patterns of autonomic regulation into musical soundscapes. Specifically, the study examined whether SAT led to improvements in self-reported biobehavioral state (e.g. relaxation, breathing slowly, interoceptive clarity), and whether individuals with poorer baseline functioning (i.e., increased autonomic reactivity and anxiety/depression symptoms) reported greater improvements in biobehavioral state following SAT. It also sought to determine whether there would be changes in endogenous oxytocin level, and whether individuals who exhibit larger gains in biobehavioral state would show greater increases in oxytocin. The current study examined data obtained from four samples, with 72 participants providing data virtually and 41 participants providing data in-person. Participants completed self-report measures of biobehavioral state, autonomic reactivity, and psychiatric symptomatology (i.e. anxiety and depression). Salivary oxytocin (pg/mL) was assessed via enzyme immunoassay in the participants who completed the study in person, with samples collected pre-and post-SAT. Following SAT, participants reported significant improvements in total biobehavioral state and the low and high arousal subscales. We also found that participants scoring above the cutoff for autonomic reactivity, anxiety, and depression reported greater increases in total biobehavioral state and decreases in the high arousal subscale. Greater decreases in the low arousal subscale were observed in the participants with increased anxiety. The subset of participants with salivary oxytocin samples exhibited increases in salivary oxytocin. Thus, our results support the potential of SAT as a low-cost, non-invasive auditory probe for improving wellbeing, especially for clinical populations experiencing autonomic dysregulation and psychiatric difficulties, such as anxiety and depression. ClinicalTrials.gov, identifiers NCT06710886, NCT06902506, NCT06580119, and NCT07065227.

如何引用

Frontiers in psychiatry 的其他文献

• 化疗相关的认知障碍和针对神经系统的非药物干预：系统综述
• 基于群体的心理社会干预减少了精神疾病的内化污名：以ISMI为重点的系统评价
• 青少年抑郁症的皮质高阈值和低激活特征：跨年龄差异分析
• HCC患者死亡焦虑和治疗依从性的联合潜在特征
• 一年级医学生抑郁焦虑应激与肥胖的相关性：久坐行为的中介作用
• 精神病学中任务一致的结果学习：减少终点稀释
• 自闭症患者的不良后果：心理健康、身体健康、社会和生活方式领域的综合综述
• 自主神经系统对二次接触灾害相关图像的反应
• 简要报告：自闭症青年初始队列中焦虑和抑郁症状的联合轨迹
• 咽肌组织和颏舌肌运动对悬雍垂腭咽成形术后阻塞性睡眠呼吸暂停低通气综合征的影响