简要报告：自闭症青年初始队列中焦虑和抑郁症状的联合轨迹
Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth.
摘要(中文译文)
焦虑和抑郁症状在孤独症青少年中较为常见，但关于其从童年到青少年期轨迹的模式及相互关系所知甚少，而这一阶段正是社会和学业需求不断增加的时期。本研究采用平行过程潜变量增长曲线模型，在一个沟通能力各异的孤独症青少年初始队列中，考察了7至16岁期间照护者报告的抑郁和焦虑症状的联合轨迹，包括初始水平和变化速率。我们还考察了孤独症特质、出生时指定性别、情绪反应性和沟通能力作为潜在预测因素。儿童焦虑和抑郁症状通过照护者大约每年填写的儿童行为量表焦虑问题和情感问题分量表进行评估。焦虑症状从童年到青少年期相对稳定，而抑郁症状平均呈上升趋势；这些总体趋势之下存在显著的个体轨迹异质性。研究结果提示焦虑和抑郁症状存在横断面和纵向的共现。更强的孤独症特质和情绪反应性与更高的初始焦虑和抑郁症状相关，但与轨迹无关。更强的沟通能力与更高的初始焦虑相关，但焦虑症状随时间下降。研究结果表明，孤独症青少年在童年和青少年期抑郁症状存在群体水平的变化，且焦虑和抑郁症状呈同步演变。这表明在这一时期联合监测焦虑和抑郁症状的重要性，其变化可能对早期识别和干预具有提示意义。考虑焦虑症状表现如何随发育演变，可能是识别高危亚组的有益下一步。
Abstract
Anxiety and depression symptoms are common among autistic youth, yet little is known about the pattern and relationship of their trajectories from childhood into adolescence, a period of increasing social and academic demands. This study used parallel process latent growth curve models to examine joint trajectories, including initial levels and rate of change in caregiver-reported depression and anxiety symptoms across age 7-16 within an inception cohort of autistic youth with varied communication abilities. We also examined autistic traits, sex assigned at birth, emotional reactivity and communication ability as potential predictors. Child anxiety and depression symptoms were estimated from Child Behavior Checklist Anxiety and Affective Problems subscales, completed by caregivers approximately annually. Whereas anxiety symptoms were relatively stable from childhood into adolescence, depression symptoms increased on average; significant heterogeneity of individual trajectories underlaid these overall trends. Findings indicated cross-sectional and longitudinal co-occurrence of anxiety and depression symptoms. Greater autistic traits and emotional reactivity correlated with greater initial anxiety and depression symptoms, but not their trajectories. Stronger communication ability correlated with more initial anxiety, but decreasing anxiety symptoms over time. Findings indicate group-level changes in depression symptoms and synchronous evolution of anxiety and depression symptoms in autistic youth across childhood and adolescence. This indicates the importance of joint monitoring of anxiety and depression symptoms in this period, with changes being potentially informative for early detection and intervention. Considering how anxiety symptom presentation may evolve across development may be a helpful next step to identifying at-risk subgroups.
如何引用
AMA
Michelle C Hunsche, Anat Zaidman-Zait, Melissa Olana, Peter Szatmari, Teresa Bennett, Eric Duku, et al. Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth.. Frontiers in psychiatry. 2026; doi:10.3389/fpsyt.2026.1741956.
APA
Michelle C Hunsche, Anat Zaidman-Zait, Melissa Olana, Peter Szatmari, Teresa Bennett, Eric Duku, et al (2026). Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth.. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2026.1741956
GB/T 7714
Michelle C Hunsche, Anat Zaidman-Zait, Melissa Olana, Peter Szatmari, Teresa Bennett, Eric Duku, et al. Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth.[J]. Frontiers in psychiatry, 2026 doi:10.3389/fpsyt.2026.1741956.
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