自闭症患者的不良后果：心理健康、身体健康、社会和生活方式领域的综合综述
Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains.
摘要(中文译文)
自闭症人群在诸多领域面临广泛不良结局的风险增高，影响日常生活的各个方面。尽管已有单项综述探讨了特定的结局领域，但尚缺乏全面的跨领域综合。由于证据涵盖多样的结局类型和综述设计，需要采用叙述性伞状综合来整合异质性综述的研究发现，并提供更广泛的系统层面概览。本伞状综述识别并综合了已发表的关于自闭症相关结局的系统综述、荟萃分析综述和叙述性综述。检索了五个数据库，检索时间自建库至2024年6月。进行了双人筛选和多审稿人数据提取，并使用公认的综述工具评价方法学质量。采用归纳性叙述综合汇总研究结果，领域分组和主题分类由综述作者共识确定。在识别的13，841条记录中，134篇综述符合纳入标准。结局被归入三个组织领域：心理健康、身体健康以及社会与生活方式。报告最为一致的不良结局包括焦虑和心境障碍、自杀倾向和自伤、进食障碍和精神病性障碍、睡眠问题、癫痫、胃肠道和喂养困难、肥胖、口腔健康问题、死亡风险增加、受害和欺凌、生活质量下降、孤独感、人际关系困难以及失业。不同结局的证据强度各异，但多项独立综述均报告了风险升高的模式。自闭症人群的不良结局影响生活的多个方面。本伞状综合识别了综述级证据支持的主要结局集群，并突出了研究、临床实践和服务规划方面的优先事项。https://www.crd.york.ac.uk/prospero/，标识号CRD42023475389。
Abstract
Autistic people experience an increased risk of a wide range of adverse outcomes across many domains, impacting all aspects of daily life. While individual reviews have explored specific outcome areas, a comprehensive cross-domain synthesis is lacking. Because the evidence spans diverse outcome types and review designs, a narrative umbrella synthesis is needed to integrate findings across heterogeneous reviews and provide a broader systems-level overview. This umbrella review identified and synthesised published systematic, meta-analytic, and narrative reviews on the outcomes associated with autism. Five databases were searched from inception to June 2024. Dual screening and multi-reviewer data extraction were conducted, and methodological quality was appraised using established review tools. Findings were aggregated using inductive narrative synthesis, with domain grouping and thematic classification determined by consensus among reviewers. Of 13,841 records identified, 134 reviews met inclusion criteria. Outcomes were grouped into three organisational domains: mental health, physical health, and social and lifestyle. The most consistently reported adverse outcomes included anxiety and mood disorders, suicidality and self-harm, eating and psychotic disorders, sleep problems, epilepsy, gastrointestinal and feeding difficulties, obesity, oral health problems, increased mortality risk, victimisation and bullying, reduced quality of life, loneliness, relationship difficulties, and unemployment. Evidence strength varied across outcomes, but elevated risk patterns were reported across multiple independent reviews. Adverse outcomes for autistic people affect multiple areas of life. This umbrella synthesis identifies the principal outcome clusters supported by review-level evidence and highlights research, clinical practice, and service planning priorities. https://www.crd.york.ac.uk/prospero/, identifier CRD42023475389.
如何引用
AMA
Blandine French, Victoria Newell, Gamze Nalbant, Hannah Wright, David Daley, Sarah Cassidy. Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains.. Frontiers in psychiatry. 2026; doi:10.3389/fpsyt.2026.1702822.
APA
Blandine French, Victoria Newell, Gamze Nalbant, Hannah Wright, David Daley, Sarah Cassidy (2026). Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains.. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2026.1702822
GB/T 7714
Blandine French, Victoria Newell, Gamze Nalbant, Hannah Wright, David Daley, Sarah Cassidy. Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains.[J]. Frontiers in psychiatry, 2026 doi:10.3389/fpsyt.2026.1702822.
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