中年女性肥胖与特定领域更年期症状严重程度：中国东部一项横断面临床研究
Adiposity and domain-specific menopausal symptom severity in midlife women: a cross-sectional clinical study in eastern china.
摘要(中文译文)
探讨中国华东地区围绝经期和绝经后女性临床特征队列中体重指数（BMI）与绝经症状患病率及严重程度之间的关联。在这项横断面研究中，于2022年6月至2025年6月期间从浙江大学医学院附属杭州市妇产科医院围绝经期保健中心招募了1，371名40至60岁女性。采用标准化方案进行人体测量，并根据中国指南定义BMI分类。使用改良Kupperman绝经指数评估绝经症状。采用方差分析或卡方检验评估不同BMI组间的差异，并使用Pearson相关分析检验BMI与症状严重程度之间的相关性。血管舒缩症状是该队列中最常见的绝经主诉，76.6%的参与者报告有此症状。性功能障碍（72.4%）、疲劳（72.0%）、失眠（71.8%）和情绪波动（66.3%）的发生率也较高。尽管绝经症状的总体患病率在不同BMI分类间无显著差异，但若干领域的症状严重程度较高。具体而言，BMI与血管舒缩症状、情绪波动、性功能障碍和泌尿系统症状之间存在显著正相关。在调整腰臀比的多变量分析中，这些关联仍具有统计学显著性，但效应量较小。一致地，与正常体重女性相比，肥胖女性的血管舒缩、性和泌尿系统症状评分显著更高。虽然BMI与总体症状患病率无关，但其与部分症状领域严重程度的轻度增加相关。鉴于效应量较小且为横断面设计，这些发现应谨慎解读。临床试验编号：不适用。
Abstract
To investigate the association between body mass index (BMI) and the prevalence and severity of menopausal symptoms in a clinically characterized cohort of peri- and postmenopausal women in Eastern China. In this cross-sectional study, 1,371 women aged 40-60 years were recruited from the Perimenopausal Health Care Center of Hangzhou Women's Hospital, Zhejiang University School of Medicine, between June 2022 and June 2025. Anthropometric measurements were obtained using standardized protocols, and BMI categories were defined according to Chinese guidelines. Menopausal symptoms were evaluated using the modified Kupperman Menopausal Index. Differences across BMI groups were assessed using analysis of variance or chi-square tests, and correlations between BMI and symptom severity were examined using Pearson correlation analysis. Vasomotor symptoms were the most prevalent menopausal complaints in this cohort, reported by 76.6% of participants. High frequencies were also observed for sexual dysfunction (72.4%), fatigue (72.0%), insomnia (71.8%), and mood swings (66.3%). Although the overall prevalence of menopausal symptoms did not differ significantly across BMI categories, symptom severity was greater in several domains. Specifically, there were significant positive correlations between BMI and vasomotor symptoms, mood swings, sexual dysfunction, and urinary symptoms. These associations remained statistically significant but modest in multivariable analyses adjusting for waist-to-hip ratio. Consistently, women with obesity had significantly higher scores for vasomotor, sexual, and urinary symptoms compared with women of normal weight. While BMI was not associated with overall symptom prevalence, it was associated with modest increases in the severity of selected symptom domains. These findings should be interpreted cautiously given the small effect sizes and cross-sectional design. Clinical trial number: not applicable.
如何引用
AMA
Miao Deng, Hongyan Zhang, Zhifen Zhang, Nan Chen. Adiposity and domain-specific menopausal symptom severity in midlife women: a cross-sectional clinical study in eastern china.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1831154.
APA
Miao Deng, Hongyan Zhang, Zhifen Zhang, Nan Chen (2026). Adiposity and domain-specific menopausal symptom severity in midlife women: a cross-sectional clinical study in eastern china.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1831154
GB/T 7714
Miao Deng, Hongyan Zhang, Zhifen Zhang, Nan Chen. Adiposity and domain-specific menopausal symptom severity in midlife women: a cross-sectional clinical study in eastern china.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1831154.
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