从侵入性活检技术向液体活检技术的转变：狼疮肾炎生物标志物的文献计量分析和前瞻性见解
Transitioning from invasive to liquid biopsy techniques: a bibliometric analysis and prospective insights on biomarkers in lupus nephritis.
摘要(中文译文)
狼疮性肾炎(LN)显著增加系统性红斑狼疮(SLE)患者的发病率和死亡率。尽管肾活检是诊断的“金标准”，但其有创性限制了疾病的持续监测。近年来，研究聚焦于无创“液体活检”生物标志物，尤其是尿液中的标志物。本研究采用文献计量学方法分析LN生物标志物研究的发展与趋势，突出近期进展与未来方向。我们从Web of Science核心合集和PubMed数据库收集了2005年至2024年间关于LN生物标志物的原创研究论文。我们使用CiteSpace、VOSviewer和Bibliometrix进行文献计量学分析，纳入2025项关于尿液生物标志物、肾脏病理、疾病活动度和长期结局的研究。分析涵盖576篇文章，揭示了该领域三个不同的发展阶段，并伴随2016年以来发表量的显著激增。中国和美国是主要贡献者，美国在引用影响力和合作方面领先。最活跃的期刊发挥着关键的知识库作用。关键词和引文分析揭示了从传统免疫学标志物向无创尿液生物标志物（如MCP-1、NGAL、CD163和补体相关分子）的转变，同时多组学方法和预测模型得到采用。LN生物标志物研究正从发现走向临床应用。单细胞和空间组学的进展正将焦点从外周生物标志物转向肾脏分子表型，支持“液体活检”策略。未来工作将强调人工智能驱动的多组学整合、最小生物标志物组合和跨种族验证，以开发精准、无创的LN监测系统。
Abstract
Lupus nephritis (LN) significantly contributes to morbidity and mortality in systemic lupus erythematosus (SLE) patients. Although renal biopsy is the diagnostic "gold standard," its invasiveness limits ongoing disease monitoring. Recently, research has focused on non-invasive "liquid biopsy" biomarkers, especially in urine. This study uses bibliometric methods to analyze the development and trends in LN biomarker research, highlighting recent advancements and future directions. We collected original research articles on LN biomarkers from the Web of Science Core Collection and PubMed databases from 2005 to 2024. We conducted a bibliometric analysis using CiteSpace, VOSviewer, and Bibliometrix, and included 2025 studies on urinary biomarkers, renal pathology, disease activity, and long-term outcomes. The analysis encompassed 576 articles, revealing three distinct developmental phases in the field, accompanied by a notable surge in publications since 2016. China and the United States are the top contributors, with the U.S. leading in citation impact and collaboration. The most active journal functions as a crucial repository of knowledge. Keyword and citation analysis reveal a shift from traditional immunological markers to non-invasive urinary biomarkers, such as MCP-1, NGAL, CD163, and complement-related molecules, alongside the adoption of multi-omics approaches and predictive models. Research on LN biomarkers is moving from discovery to clinical application. Advances in single-cell and spatial omics are shifting focus from peripheral biomarkers to renal molecular phenotypes, supporting "liquid biopsy" strategies. Future efforts will emphasize AI-driven multi-omics integration, minimal biomarker panels, and cross-ethnic validation to develop a precise, non-invasive LN monitoring system.
如何引用
AMA
Chen Liu, Yanhao Chen, Xiang Li, Shuo Huang, Yongsheng Fan, Jie Bao. Transitioning from invasive to liquid biopsy techniques: a bibliometric analysis and prospective insights on biomarkers in lupus nephritis.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1796760.
APA
Chen Liu, Yanhao Chen, Xiang Li, Shuo Huang, Yongsheng Fan, Jie Bao (2026). Transitioning from invasive to liquid biopsy techniques: a bibliometric analysis and prospective insights on biomarkers in lupus nephritis.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1796760
GB/T 7714
Chen Liu, Yanhao Chen, Xiang Li, Shuo Huang, Yongsheng Fan, Jie Bao. Transitioning from invasive to liquid biopsy techniques: a bibliometric analysis and prospective insights on biomarkers in lupus nephritis.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1796760.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出