肾脏类器官技术在肾脏疾病研究和临床翻译中的进展和未来前景
Advances and future perspectives of kidney organoid technology in renal disease research and clinical translation.
摘要(中文译文)
肾脏类器官作为能够再现人类肾脏结构和功能特征的三维模型，近年来在阐明肾脏疾病机制、药物筛选及个性化治疗评估方面取得了显著进展。本综述全面概述了当前肾脏类器官的构建技术、其在肾脏疾病研究和治疗中的应用，以及尚存的组织工程与转化挑战。重点关注血管化策略、与生物打印和器官芯片平台的整合、免疫微环境模拟以及长期培养技术等方面的最新进展。我们进一步讨论了临床转化中的关键瓶颈，如大规模生产、数据可重复性以及伦理与监管考量。最后，我们展望了肾脏类器官与精准医学、微流控系统和生物传感技术融合的新兴趋势。肾脏类器官有望推动生物技术、再生医学和药物研发的创新，为肾脏疾病的精准诊断和治疗提供强有力的平台。
Abstract
Kidney organoids, as three-dimensional models that recapitulate the structural and functional features of the human kidney, have made significant strides in recent years in elucidating the mechanisms of renal diseases, drug screening, and personalized therapeutic evaluation. This review provides a comprehensive overview of the current technologies for kidney organoid generation, their applications in renal disease research and treatment, and the engineering and translational challenges that remain. Particular focus is placed on recent advances in vascularization strategies, integration with bioprinting and organ-on-chip platforms, simulation of the immune microenvironment, and long-term culture techniques. We further discuss key bottlenecks in clinical translation, such as large-scale production, data reproducibility, and ethical and regulatory considerations. Finally, we highlight emerging trends in the convergence of kidney organoids with precision medicine, microfluidic systems, and biosensing technologies. Kidney organoids are poised to drive innovation in biotechnology, regenerative medicine, and pharmaceutical development, providing a powerful platform for the precise diagnosis and treatment of renal diseases.
如何引用
AMA
Zichun Zhao, Kuan Tong, Kunfei Deng, Hongjie Liu, Yu Li, Danni Wang. Advances and future perspectives of kidney organoid technology in renal disease research and clinical translation.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1815902.
APA
Zichun Zhao, Kuan Tong, Kunfei Deng, Hongjie Liu, Yu Li, Danni Wang (2026). Advances and future perspectives of kidney organoid technology in renal disease research and clinical translation.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1815902
GB/T 7714
Zichun Zhao, Kuan Tong, Kunfei Deng, Hongjie Liu, Yu Li, Danni Wang. Advances and future perspectives of kidney organoid technology in renal disease research and clinical translation.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1815902.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出