CALLY指数在脓毒症中的预后价值：一项系统综述和荟萃分析
The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis.
摘要(中文译文)
C反应蛋白-白蛋白-淋巴细胞（CALLY）指数是一种反映炎症、营养和免疫状态的复合生物标志物，然而由于证据不一致，其在脓毒症中的预后价值仍不确定。本荟萃分析旨在阐明CALLY指数与脓毒症患者预后之间的关系。系统检索了PubMed、Embase、OVID、Web of Science、中国知网、万方数据库、Google Scholar和百度学术，检索截止日期为2025年11月15日。纳入报告CALLY指数与死亡率关联或比较脓毒症存活者与非存活者CALLY指数水平的研究。采用随机效应模型，以标准化均数差（SMD）、风险比（HR）和比值比（OR）及其95%置信区间（CI）对数据进行合并。本荟萃分析共纳入六项研究，涵盖七个队列，包括3,848例脓毒症患者。总体而言，CALLY指数在存活者与非存活者之间无显著差异（合并SMD = -0.22，95% CI：-1.18至0.74）。然而，亚组分析显示出明显差异：在中国队列中，较高的CALLY指数与生存相关（SMD = -1.04，95% CI：-1.69至-0.39），而在土耳其队列中，其与死亡相关（SMD = 1.39，95% CI：1.02至1.75）。多因素分析进一步显示，较高的CALLY指数与较低的死亡风险显著相关（HR = 0.48，95% CI：0.33-0.69）。CALLY指数预测死亡的诊断准确性为中等，合并敏感度为0.59，特异度为0.77。所有合并分析中均观察到显著异质性。CALLY指数有望成为一种低成本的脓毒症生物标志物，但其与死亡率在不同种族人群中的关联存在差异，仍需在大型跨国前瞻性研究中加以验证。注册号：INPLASY2025120023。http://inplasy.com。
Abstract
The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite biomarker of inflammation, nutrition, and immunity, yet its prognostic value in sepsis remains uncertain due to inconsistent evidence. This meta-analysis seeks to clarify the relationship between the CALLY index and prognosis in septic patients. A systematic search of PubMed, Embase, OVID, Web of Science, the China National Knowledge Infrastructure, the Wanfang Database, Google Scholar, and Baidu Scholar was conducted up to November 15, 2025. Studies reporting on the CALLY index's association with mortality or its levels in sepsis survivors versus non-survivors were included. Data were pooled using standardized mean differences (SMDs), hazard ratios (HRs), and odds ratios (ORs) with 95% confidence intervals (CIs) under a random-effects model. This meta-analysis incorporated a total of six studies, encompassing seven cohorts and comprising 3,848 patients with sepsis. Overall, the CALLY index did not significantly differ between survivors and non-survivors (pooled SMD = -0.22, 95% CI: -1.18 to 0.74). However, subgroup analyses revealed a marked divergence: a higher CALLY index was correlated with survival in Chinese cohorts (SMD = -1.04, 95% CI: -1.69 to -0.39), whereas it was associated with mortality in the Turkish cohort (SMD = 1.39, 95% CI: 1.02 to 1.75). Multivariate analysis further showed a significant association between a higher CALLY index and a lower mortality risk (HR = 0.48, 95% CI: 0.33-0.69). The diagnostic accuracy of the CALLY index for predicting mortality was moderate, with a pooled sensitivity of 0.59 and specificity of 0.77. Significant heterogeneity was observed across all pooled analyses. The CALLY index shows promise as a low-cost sepsis biomarker, but its variable link to mortality across ethnic groups requires validation in large, multinational prospective studies. Identifier: INPLASY2025120023. http://inplasy.com.
如何引用
AMA
Chuangying Xie, Peng Sun, Min Zhang, Hong Fan, Zhenzhen Li, Xiang Tong. The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1812568.
APA
Chuangying Xie, Peng Sun, Min Zhang, Hong Fan, Zhenzhen Li, Xiang Tong (2026). The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1812568
GB/T 7714
Chuangying Xie, Peng Sun, Min Zhang, Hong Fan, Zhenzhen Li, Xiang Tong. The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1812568.
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