一种植入式机械-电级联平台同步神经-肌肉修复
An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.
摘要(中文译文)
周围神经损伤会触发轴突再生缓慢和不可逆的肌肉萎缩，其原因在于缺乏同步的神经肌肉修复策略。我们提出了一种完全可植入、自供电的机械驱动电适配生物电子植入系统（MEBIS），可实现协调的机械-电刺激，用于整合性神经肌肉再生。可编程机器人致动器向去神经支配的肌肉提供可量化的机械按摩，增强灌注的同时使纳米发电机发生形变，将运动转化为局部电信号。这些信号刺激受损神经，诱导细胞内Ca升高及Ca依赖性信号传导，进而激活下游HIF-1α/AMPK通路，加速施万细胞活性、血管生成和轴突再生长。这一机械-电-生化级联反应以闭环方式将肌肉保护与神经再生耦联，克服了传统刺激器的深度限制和输出不稳定性。在大鼠和猪模型中验证，MEBIS显著改善功能恢复、电生理学和组织形态计量学，且无生物相容性担忧。我们的平台为周围神经损伤后的精准修复和康复建立了一种可扩展的反馈控制范式。
Abstract
Peripheral nerve injury triggers slow axonal regeneration and irreversible muscle atrophy due to the absence of synchronous neuromuscular repair strategies. We present a fully implantable, self-powered Mechano-driven Electro-adaptable Bioelectronic Implant System (MEBIS) enabling coordinated mechanical-electrical stimulation for integrated neuromuscular regeneration. A programmable robotic actuator delivers quantifiable mechanical massage to denervated muscle, enhancing perfusion while deforming a nanogenerator that converts motion into localized electrical cues. These signals stimulate injured nerves, inducing intracellular Ca elevation and Ca-dependent signaling, which activates downstream HIF-1α/AMPK pathways to accelerate Schwann cell activity, angiogenesis, and axonal regrowth. This mechano-electro-biochemical cascade couples muscle preservation with nerve regeneration in a closed loop, overcoming depth limitations and output instability of conventional stimulators. Validated in rat and porcine models, MEBIS significantly improves functional recovery, electrophysiology, and histomorphometry without biocompatibility concerns. Our platform establishes a scalable, feedback-controlled paradigm for precision repair and rehabilitation after peripheral nerve injury.
如何引用
AMA
Liping Nan, Wentao Cao, Jiaqi Fang, Pengzhi Shi, Xuehan Jin, Jianguang Wang, et al. An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.. Nature communications. 2026; doi:10.1038/s41467-026-73535-w.
APA
Liping Nan, Wentao Cao, Jiaqi Fang, Pengzhi Shi, Xuehan Jin, Jianguang Wang, et al (2026). An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.. Nature communications. https://doi.org/10.1038/s41467-026-73535-w
GB/T 7714
Liping Nan, Wentao Cao, Jiaqi Fang, Pengzhi Shi, Xuehan Jin, Jianguang Wang, et al. An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.[J]. Nature communications, 2026 doi:10.1038/s41467-026-73535-w.
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