经颅磁刺激增强最低意识状态患者觉醒的回顾性评估：中国内蒙古的一项单中心研究
Retrospective evaluation of transcranial magnetic stimulation for enhancing arousal in patients with minimally conscious state: a single-centre study in Inner Mongolia, China.
摘要(中文译文)
本研究旨在探讨针对多个脑区的高频经颅磁刺激(TMS)对微意识状态(MCS)患者意识恢复的影响。研究对2022年8月至2024年3月期间的MCS患者进行了回顾性分析。部分患者仅接受常规康复治疗,另一些患者在此基础上接受了TMS治疗。临床结局采用格拉斯哥昏迷量表(GCS)和昏迷恢复量表修订版(CRS-R)在三个时间点进行评估:治疗前(T0)、治疗后两周(T1)和治疗后一个月(T2)。其他评估包括脑电图(EEG)、脑干听觉诱发电位(BAEP)、体感诱发电位(SEP)以及血清脑源性神经营养因子(BDNF)和神经元特异性烯醇化酶(NSE)水平。共纳入30例患者,均等分为两组。接受TMS治疗的15例患者在T1和T2时点的GCS和CRS-R评分均显示出显著改善。此外,这些患者在T1时点的EEG和BAEP分级也表现出显著提升。研究结果表明,辅助性多靶点高频重复TMS可能促进MCS患者的意识恢复。这些结果凸显了重复TMS作为MCS治疗干预手段的潜力,值得在未来的研究中进一步探讨。
Abstract
This study aimed to investigate the effect of high-frequency transcranial magnetic stimulation (TMS) targeting multiple brain regions on the recovery of consciousness in patients with minimally conscious state (MCS). A retrospective analysis was conducted on MCS patients between August 2022 and March 2024. Some patients received only conventional rehabilitation treatment, while others received additional TMS therapy. Clinical outcomes were assessed using the Glasgow Coma Scale (GCS) and the Coma Recovery Scale-Revised (CRS-R) at three time points: before treatment (T0), two weeks post-treatment (T1), and one month post-treatment (T2). Additional assessments included electroencephalogram (EEG), brainstem auditory evoked potential (BAEP), somatosensory evoked potentials (SEP), and serum levels of brain-derived neurotrophic factor (BDNF) and neuron-specific enolase (NSE). A total of 30 patients were included and divided equally into two groups. The GCS and CRS-R scores of the 15 patients who received TMS therapy demonstrated significant improvements at T1 and T2. Furthermore, these patients exhibited significant enhancements in EEG and BAEP grading at T1. The findings suggest that adjunctive multi-target high-frequency repetitive TMS may promote recovery of consciousness in MCS patients. These results underscore the potential of repetitive TMS as a therapeutic intervention for MCS and warrant further investigation in future studies.
如何引用
AMA
Wenqi Deng, Sha Wang, Lixia Zhang, Shuqi Wang, Anna Bai, Ziyu Xing, et al. Retrospective evaluation of transcranial magnetic stimulation for enhancing arousal in patients with minimally conscious state: a single-centre study in Inner Mongolia, China.. Frontiers in psychiatry. 2026; doi:10.3389/fpsyt.2026.1757883.
APA
Wenqi Deng, Sha Wang, Lixia Zhang, Shuqi Wang, Anna Bai, Ziyu Xing, et al (2026). Retrospective evaluation of transcranial magnetic stimulation for enhancing arousal in patients with minimally conscious state: a single-centre study in Inner Mongolia, China.. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2026.1757883
GB/T 7714
Wenqi Deng, Sha Wang, Lixia Zhang, Shuqi Wang, Anna Bai, Ziyu Xing, et al. Retrospective evaluation of transcranial magnetic stimulation for enhancing arousal in patients with minimally conscious state: a single-centre study in Inner Mongolia, China.[J]. Frontiers in psychiatry, 2026 doi:10.3389/fpsyt.2026.1757883.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出