可喷涂纳米酶水凝胶表观遗传学重塑炎症，促进糖尿病伤口再生
Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.
摘要(中文译文)
慢性糖尿病创面由于持续性炎症和愈合受损，构成了一项重大的临床挑战。在此，我们报道了一种可喷涂的纳米酶水凝胶，其能够从表观遗传层面重塑巨噬细胞（Mφ），从而抑制炎症并协调组织再生。通过环保型一锅法合成的超小铜基纳米酶（CuNZ，约4 nm）表现出强效的多自由基清除活性。将其整合入甲基丙烯酰化明胶（Gel）后，CuNZ@Gel展现出可喷涂性、与皮肤贴合覆盖的能力以及储存稳定性，具有良好的临床转化潜力。值得注意的是，该纳米酶水凝胶通过重塑染色质可及性，在Mφ中诱导了显著的表观遗传修饰，从而使基因表达从促炎谱向抗炎谱转变。这种表观遗传调控在氧化应激条件下得以维持，主动抑制炎症并促进再生反应。在大鼠糖尿病创面模型中，CuNZ@Gel通过其协同的抗氧化、抗炎和促再生作用，显著加速了创面愈合。与传统被动敷料不同，这种可喷涂纳米酶水凝胶通过表观遗传调控炎症，主动重塑创面微环境，为管理慢性糖尿病创面和炎症性皮肤并发症提供了一种有前景的治疗策略。
Abstract
Chronic diabetic wounds present a critical clinical challenge due to persistent inflammation and compromised healing. Here, we report a sprayable nanozyme hydrogel that epigenetically remodels macrophages (Mφ) to suppress inflammation and coordinate regeneration. Ultrasmall copper-based nanozymes (CuNZ, ~4 nm) synthesized via an eco-friendly one-pot method demonstrated potent multi-radical scavenging activity. When integrated into gelatin methacryloyl (Gel), CuNZ@Gel exhibited sprayability, conformal skin coverage, and storage stability, offering potential for clinical translation. Notably, the nanozyme hydrogel induced distinct epigenetic modifications in Mφ by remodeling chromatin accessibility, thereby shifting gene expression from a pro-inflammatory to an anti-inflammatory profile. This epigenetic modulation sustained under oxidative stress, actively suppressing inflammation while facilitating regenerative responses. In rat diabetic wound models, CuNZ@Gel significantly accelerated healing through its coordinated antioxidant, anti-inflammatory, and pro-regenerative actions. Unlike conventional passive dressings, this sprayable nanozyme hydrogel proactively remodels the wound microenvironment via epigenetic control of inflammation, providing a promising therapeutic strategy for managing chronic diabetic wounds and inflammatory skin complications.
如何引用
AMA
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, et al. Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.. Nature communications. 2026; doi:10.1038/s41467-026-72968-7.
APA
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, et al (2026). Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.. Nature communications. https://doi.org/10.1038/s41467-026-72968-7
GB/T 7714
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, et al. Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.[J]. Nature communications, 2026 doi:10.1038/s41467-026-72968-7.
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