一种有机人工心肌细胞
An organic artificial cardiomyocyte.
摘要(中文译文)
对生物兴奋性理解的进展推动了动作电位产生与传播的数学建模和硬件仿真。尽管基于无机或有机系统的神经形态器件发展迅速，但由于再现多种离子动力学过程的复杂性，以及缓慢的心脏活动与固态电子器件快速运行之间的时间失配，心形态硬件在很大程度上仍未被探索。在此，我们提出一种有机电化学心肌细胞，其中离子介导的通道电流表现出与心室离子过程相匹配的时间常数。通过再现快速钠电流以及缓慢且相互依赖的钙和钾电流，该有机电化学心肌细胞能够产生具有生物真实时相的心室样动作电位，表现出不应期以及对电或化学调控的响应性，并与活体心肌细胞的生物电信号实现同步。这些结果将心脏建模范式从纯计算模拟转向生物真实的硬件仿真。
Abstract
Advances in understanding biological excitability have driven both mathematical modeling and hardware emulation of action potential generation and propagation. While neuromorphic devices based on inorganic or organic systems have advanced rapidly, cardiomorphic hardware remains largely unexplored due to the complexity of reproducing multiple ionic dynamics and the temporal mismatch between the slow cardiac activity and the fast operation of solid-state electronics. Here, we present an organic electrochemical cardiomyocyte (OECM) in which ion-mediated channel currents exhibit time constants aligned with those of ventricular ionic processes. By reproducing a fast sodium current alongside slow, interdependent calcium and potassium currents, the OECM generates ventricular-like action potentials with biorealistic phases, displays refractoriness and responsiveness to electrical or chemical modulation, and synchronizes with bioelectric signals from living cardiomyocytes. These results shift the paradigm of cardiac modeling from purely computational simulations toward biorealistic hardware emulation.
如何引用
AMA
Dace Gao, Junpeng Ji, Simone De Prà, Miao Xiong, Wenlong Jin, Ugo Bruno, et al. An organic artificial cardiomyocyte.. Nature communications. 2026; doi:10.1038/s41467-026-72584-5.
APA
Dace Gao, Junpeng Ji, Simone De Prà, Miao Xiong, Wenlong Jin, Ugo Bruno, et al (2026). An organic artificial cardiomyocyte.. Nature communications. https://doi.org/10.1038/s41467-026-72584-5
GB/T 7714
Dace Gao, Junpeng Ji, Simone De Prà, Miao Xiong, Wenlong Jin, Ugo Bruno, et al. An organic artificial cardiomyocyte.[J]. Nature communications, 2026 doi:10.1038/s41467-026-72584-5.
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