异质性内分泌细胞组成定义了人胰岛功能表型
Heterogeneous endocrine cell composition defines human islet functional phenotypes.
摘要(中文译文)
美国最大的研究用人胰岛来源——胰岛分配综合计划（IIDP）中的表型分析和基因分型项目，对分配给研究人员的胰岛制备物进行标准化评估，并实现多种数据类型的整合。利用该流程对首批299例无糖尿病器官捐献者的胰岛数据进行分析，揭示了胰岛细胞组成存在显著异质性，且与激素分泌特征、性别、报告的种族和民族、遗传预测的祖先背景以及2型糖尿病（T2D）遗传风险相关。尽管α细胞和β细胞组成影响胰岛素和胰高血糖素的分泌特征，但δ细胞的数量与胰岛素分泌的关联最为显著，并且也与2型糖尿病遗传风险评分（GRS）相关。这些发现对于理解糖尿病异质性和胰岛功能障碍的机制具有重要意义，并可能为个性化医疗和β细胞替代治疗策略提供启示。
Abstract
Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers and enable the integration of multiple data types. Data from islets of the first 299 organ donors without diabetes analyzed using this pipeline highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D). While α and β cell composition influenced insulin and glucagon secretory traits, the abundance of δ cells showed the strongest association with insulin secretion and was also associated with the genetic risk score (GRS) for T2D. These findings have important implications for understanding mechanisms underlying diabetes heterogeneity and islet dysfunction and may provide insight into strategies for personalized medicine and β cell replacement therapy.
如何引用
AMA
Carmella Evans-Molina, Yasminye D Pettway, Diane C Saunders, Seth A Sharp, Thomas Sr Bate, Han Sun, et al. Heterogeneous endocrine cell composition defines human islet functional phenotypes.. Nature communications. 2026; doi:10.1038/s41467-026-70689-5.
APA
Carmella Evans-Molina, Yasminye D Pettway, Diane C Saunders, Seth A Sharp, Thomas Sr Bate, Han Sun, et al (2026). Heterogeneous endocrine cell composition defines human islet functional phenotypes.. Nature communications. https://doi.org/10.1038/s41467-026-70689-5
GB/T 7714
Carmella Evans-Molina, Yasminye D Pettway, Diane C Saunders, Seth A Sharp, Thomas Sr Bate, Han Sun, et al. Heterogeneous endocrine cell composition defines human islet functional phenotypes.[J]. Nature communications, 2026 doi:10.1038/s41467-026-70689-5.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出