腹膜透析患者的抑郁症状负担及其与健康相关生活质量的关系
Depressive Symptom Burden and Its Relationship With Health-Related Quality of Life in Patients on Peritoneal Dialysis.
摘要(中文译文)
背景 需要接受腹膜透析的慢性肾脏病（CKD）给患者带来了沉重的身体、情感和社会负担。在影响患者结局的非生物学因素中，抑郁症状已成为健康相关生活质量（HRQoL）的关键决定因素。然而，在接受腹膜透析的患者中，抑郁与HRQoL之间的关系尚未得到充分阐明，尤其是在拉丁美洲人群中。目的 评估接受腹膜透析的CKD患者中抑郁症状与HRQoL的关系。方法 于2025年6月至12月在墨西哥社会保障研究所（IMSS）一家二级医疗中心开展了一项观察性横断面研究。共纳入150例接受腹膜透析的成年患者。采用肾脏病生活质量-36（KDQOL-36）量表评估HRQoL，采用患者健康问卷-9（PHQ-9）评估抑郁症状。描述性统计以中位数和四分位距（IQR；q25-q75）或频数和百分比表示。采用Spearman秩相关系数评估变量之间的关系。结果 HRQoL评分中位数为53.19（q25-q75：38.7-65.7），PHQ-9评分中位数为7分（q25-q75：4-11），主要对应于轻度抑郁症状。观察到抑郁症状与HRQoL之间存在强且具有统计学意义的负相关关系（rₛ = -0.771，p<0.001）。此外，随着抑郁症状严重程度的增加，生活质量评分呈进行性下降，显示出明显的梯度效应。结论 在接受腹膜透析的患者中，抑郁症状与HRQoL受损密切相关。这些发现凸显了将常规心理健康评估和多学科干预纳入肾脏病照护以提高以患者为中心的结局的重要性。
Abstract
Background Chronic kidney disease (CKD) requiring peritoneal dialysis imposes a substantial physical, emotional, and social burden on patients. Among the non-biological factors influencing patient outcomes, depressive symptoms have emerged as a key determinant of health-related quality of life (HRQoL). However, the relationship between depression and HRQoL has not been fully characterized in patients undergoing peritoneal dialysis, particularly in Latin American populations. Objective To evaluate how depressive symptoms relate to HRQoL in patients with CKD undergoing peritoneal dialysis. Methods An observational, cross-sectional study was conducted at a second-level healthcare center of the Mexican Social Security Institute (IMSS) between June and December 2025. A total of 150 adult patients undergoing peritoneal dialysis were included. HRQoL was assessed using the Kidney Disease Quality of Life-36 (KDQOL-36) instrument, and depressive symptoms were evaluated using the Patient Health Questionnaire-9 (PHQ-9). Descriptive statistics were expressed as medians and interquartile ranges (IQR; q25-q75) or frequencies and percentages. Spearman's rank correlation coefficient was used to evaluate the relationship between variables. Results The median HRQoL score was 53.19 (q25-q75: 38.7-65.7), and the median PHQ-9 score was seven (q25-q75: 4-11), corresponding predominantly to mild depressive symptoms. A strong and statistically significant inverse relationship was observed between depressive symptoms and HRQoL (rₛ = -0.771, p<0.001). Additionally, a progressive decline in quality of life scores was identified with increasing severity of depressive symptoms, demonstrating a clear gradient effect. Conclusion Depressive symptoms are strongly related to impaired HRQoL among patients receiving peritoneal dialysis. These findings highlight the importance of incorporating routine mental health assessment and multidisciplinary interventions into nephrology care to improve patient-centered outcomes.
如何引用
AMA
Cecilia Salud-Gutiérrez, Ulises Avedaño-Ignacio, Merhary B Meza-Matus, Alfredo González-Ayala, Nallely Rincón Peregrino, Quitzia L Torres-Salazar. Depressive Symptom Burden and Its Relationship With Health-Related Quality of Life in Patients on Peritoneal Dialysis.. Cureus. 2026; doi:10.7759/cureus.106297.
APA
Cecilia Salud-Gutiérrez, Ulises Avedaño-Ignacio, Merhary B Meza-Matus, Alfredo González-Ayala, Nallely Rincón Peregrino, Quitzia L Torres-Salazar (2026). Depressive Symptom Burden and Its Relationship With Health-Related Quality of Life in Patients on Peritoneal Dialysis.. Cureus. https://doi.org/10.7759/cureus.106297
GB/T 7714
Cecilia Salud-Gutiérrez, Ulises Avedaño-Ignacio, Merhary B Meza-Matus, Alfredo González-Ayala, Nallely Rincón Peregrino, Quitzia L Torres-Salazar. Depressive Symptom Burden and Its Relationship With Health-Related Quality of Life in Patients on Peritoneal Dialysis.[J]. Cureus, 2026 doi:10.7759/cureus.106297.
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