泪腺腺样囊性癌伴晚期下颌骨转移表现为口内肿块：一例病例报告及文献综述
Adenoid Cystic Carcinoma of the Lacrimal Gland With Late Mandibular Metastasis Presenting as an Intraoral Mass: A Case Report and Literature Review.
摘要(中文译文)
泪腺腺样囊性癌（adenoid cystic carcinoma，ACC）是一种少见但临床侵袭性强的恶性肿瘤，以神经周围侵犯、局部复发和迟发性远处转移为特征。下颌骨转移极为罕见。我们报告一例61岁男性，表现为进行性右眼眶肿胀、眼球突出和视力丧失。影像学显示破坏性泪腺肿块并累及颞骨。患者接受了手术减瘤及放疗，随后出现局部复发。两年后，患者出现无痛性右下颌后部肿胀，表现为近期拔牙部位附近的口内肿块。影像学和组织病理学证实为转移性ACC。尽管接受了全身化疗和追加放疗，病变仍进展。本病例强调了对泪腺ACC进行长期监测以及对新发口腔或颌面部病变进行仔细评估的必要性，因为转移性疾病可能类似于良性牙源性病变，并可在初始治疗数年后出现。
Abstract
Adenoid cystic carcinoma (ACC) of the lacrimal gland is an uncommon but clinically aggressive malignancy, characterized by perineural invasion, local recurrence, and delayed distant metastasis. Mandibular metastasis is exceptionally rare. We report a 61-year-old man who presented with progressive right orbital swelling, proptosis, and visual loss. Imaging demonstrated a destructive lacrimal gland mass with temporal bone involvement. The patient underwent surgical debulking followed by radiotherapy, with subsequent local recurrence. Two years later, he developed a painless right posterior mandibular swelling presenting as an intraoral mass near a recent dental extraction site. Imaging and histopathology confirmed metastatic ACC. Despite systemic chemotherapy and additional radiotherapy, the lesion progressed. This case underscores the need for long-term surveillance in lacrimal gland ACC and careful assessment of new oral or maxillofacial lesions, as metastatic disease may mimic benign odontogenic conditions and present years after initial treatment.
如何引用
AMA
Kostas Boboridis, Zoi Karagiannidou, Kostas Vahtsevanos. Adenoid Cystic Carcinoma of the Lacrimal Gland With Late Mandibular Metastasis Presenting as an Intraoral Mass: A Case Report and Literature Review.. Cureus. 2026; doi:10.7759/cureus.108301.
APA
Kostas Boboridis, Zoi Karagiannidou, Kostas Vahtsevanos (2026). Adenoid Cystic Carcinoma of the Lacrimal Gland With Late Mandibular Metastasis Presenting as an Intraoral Mass: A Case Report and Literature Review.. Cureus. https://doi.org/10.7759/cureus.108301
GB/T 7714
Kostas Boboridis, Zoi Karagiannidou, Kostas Vahtsevanos. Adenoid Cystic Carcinoma of the Lacrimal Gland With Late Mandibular Metastasis Presenting as an Intraoral Mass: A Case Report and Literature Review.[J]. Cureus, 2026 doi:10.7759/cureus.108301.
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