子宫内膜癌组织病理学参数与分子标志物的相关性
Correlation of Histopathological Parameters With Molecular Markers in Carcinoma Endometrium.
摘要(中文译文)
评估子宫内膜癌（EC）中分子标志物与组织病理学参数之间的关联。这项回顾性研究于2022年1月至2025年5月在印度新德里Max癌症护理研究所进行，共纳入160例子宫内膜癌患者。通过免疫组织化学（IHC）检测p53、错配修复（MMR）蛋白及POLE突变状态来确定分子亚型，并在适用时归类为“无特定分子特征”（NSMP）。评估组织病理学变量，包括组织学亚型、肿瘤分级、分期、肌层浸润深度、淋巴血管间隙浸润（LVSI）及淋巴结状态，采用卡方统计分析其与分子亚型的关联。观察到分子亚型与组织学类型及LVSI之间存在显著关联。组织病理学参数与肿瘤分级之间呈强相关性（p<0.0001）。然而，分子亚型与疾病分期之间未发现显著关联（p=0.136）。POLE突变罕见，仅见于0.6%的病例。基于癌症基因组图谱（TCGA）分类的免疫组织化学标志物与已确立的组织病理学危险因素显示出强相关性。将分子分型整合到常规诊断流程中可能改善子宫内膜癌的预后评估并支持个体化治疗策略。
Abstract
To assess the association between molecular markers and histopathological parameters in endometrial carcinoma (EC). This retrospective study was conducted at the Max Institute of Cancer Care, New Delhi, India, from January 2022 to May 2025, and included a total of 160 patients with EC. Molecular subtypes were determined using immunohistochemistry (IHC) for p53, mismatch repair (MMR) proteins, and POLE mutation status, and classified as "no specific molecular profile" (NSMP) where applicable. Histopathological variables, including histological subtype, tumor grade, stage, depth of myometrial invasion, lymphovascular space invasion (LVSI), and lymph node status, were evaluated for association with molecular subtypes using chi-square statistical analysis. Significant associations were observed between molecular subtypes and both histological type and LVSI. A strong correlation was noted between histopathological parameters and tumor grade (p<0.0001). However, no significant association was found between molecular subtypes and disease stage (p=0.136). POLE mutations were rare, identified in only 0.6% of cases. Immunohistochemical markers based on The Cancer Genome Atlas (TCGA) classification show a strong correlation with established histopathological risk factors. Integrating molecular profiling into the routine diagnostic workup may improve prognostication and support personalized treatment strategies in EC.
如何引用
AMA
Kanika B Modi, Anjali Chandra, Aparna Dhar, Shefali Sardana, Sandeep Batra, Atul Sharma, et al. Correlation of Histopathological Parameters With Molecular Markers in Carcinoma Endometrium.. Cureus. 2026; doi:10.7759/cureus.106256.
APA
Kanika B Modi, Anjali Chandra, Aparna Dhar, Shefali Sardana, Sandeep Batra, Atul Sharma, et al (2026). Correlation of Histopathological Parameters With Molecular Markers in Carcinoma Endometrium.. Cureus. https://doi.org/10.7759/cureus.106256
GB/T 7714
Kanika B Modi, Anjali Chandra, Aparna Dhar, Shefali Sardana, Sandeep Batra, Atul Sharma, et al. Correlation of Histopathological Parameters With Molecular Markers in Carcinoma Endometrium.[J]. Cureus, 2026 doi:10.7759/cureus.106256.
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